eXaSkin: A novel high-density bolus for 6MV X-rays radiotherapy

Al-sudani, T; Biasi, Giordano; Wilkinson, Dean; Davis, Joel; Kearnan, Royce; Matar, Fatima S.; Cutajar, Dean L; Metcalfe, Peter E; Rosenfeld, Anatoly B.

doi:10.1016/j.ejmp.2020.09.002

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…In the treatment of an irregular surface such as the fingers or toes, low energy in the kV range can lead to an inadequate tumor coverage and excess doses, thus high-energy photon beams in the MV range are generally employed to deliver a homogeneous dose distribution to the tumor [ 3 ]. Nevertheless, high-energy photon beams deliver a lower dose to the surface than to deeper tissue due to their high penetration and the consequent build-up effect, which has a skin-sparing effect that minimizes the dose delivered to superficial tumors [ 4 , 5 ]. As a result, in RT for shallow tumors, megavoltage photon beams have lower treatment effectiveness [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Application of a Customized 3D-Printed Bolus in Radiation Therapy for Distal Extremities

Ahn

Choi

et al. 2023

Life

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In radiation therapy (RT) for skin cancer, tissue-equivalent substances called boluses are widely used to ensure the delivery of an adequate dose to the skin surface and to provide a radioprotective effect for normal tissue. The aim of this study was to develop a new type of three-dimensional (3D) bolus for RT involving body parts with irregular geometries and to evaluate its clinical feasibility. Two 3D-printed boluses were designed for two patients with squamous cell carcinoma (SCC) of their distal extremities based on computed tomography (CT) images and printed with polylactic acid (PLA). The clinical feasibility of the boluses was evaluated by measuring the in vivo skin dose at the tumor site with optically stimulated luminescence detectors (OSLDs) and comparing the results with the prescribed and calculated doses from the Eclipse treatment planning system (TPS). The average measured dose distribution for the two patients was 94.75% of the prescribed dose and 98.8% of the calculated dose. In addition, the average measured dose during repeated treatments was 189.5 ± 3.7 cGy, thus demonstrating the excellent reproducibility of the proposed approach. Overall, the customized 3D-printed boluses for the RT of distal extremities accurately delivered doses to skin tumors with improved reproducibility.

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Section: Introductionmentioning

confidence: 99%

Clinical Application of a Customized 3D-Printed Bolus in Radiation Therapy for Distal Extremities

Ahn

Choi

et al. 2023

Life

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Dosimetric characteristics of a thin bolus made of variable shape tungsten rubber for photon radiotherapy

et al. 2021

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The development and characterization of an all-purpose bolus for radiotherapy

et al. 2023

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Objective. The purpose of this study was to develop a new bolus (HM bolus), with tissue equivalence, transparency, reusability, and free shaping at approximately 40 °C for excellent adhesion, and to evaluate the feasibility of clinically using this bolus as an ideal bolus. Approach. We summarized the advantages and disadvantages of existing boluses. To evaluate dose characteristics, a vinyl gel sheet bolus (Gel bolus) and HM bolus placed on a water-equivalent phantom were used to obtain the percent depth dose (PDD) of electron (6 MeV, 9 MeV) and photon (4 MV, 6 MV) beams. The average dose difference of the HM bolus and Gel bolus was calculated. The Gel bolus, a soft rubber bolus (SR bolus), and HM bolus were placed in adherence to a pelvic phantom. CT images taken after shaping and 1, 2, and 3 weeks after shaping were used to evaluate the adhesion and reproducibility using air gap and dice similarity coefficient (DSC). Main results. The average dose difference for electron beams was 0.16% ± 0.79% and photon beams was 0.06% ± 0.34%, both within 1% of the PDD results. The HM bolus showed the same build-up effect and dose characteristics as the Gel bolus. The mean air gap values for the Gel bolus, SR bolus, and HM bolus were 96.02 ± 43.77 cm3, 34.93 ± 21.44 cm3, and 4.40 ± 1.50 cm3, respectively. The mean DSC values compared to initial images for the Gel bolus, SR bolus, and HM bolus were 0.363 ± 0.035, 0.556 ± 0.042, and 0.837 ± 0.018, respectively. Excellent adhesion was observed in the CT simulation and during the treatment period. Significance. The HM bolus has unique features, such as tissue equivalence, transparency, reusability, and free shaping for excellent adhesion, and is thus an ideal bolus for use in clinical cases.

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eXaSkin: A novel high-density bolus for 6MV X-rays radiotherapy

Cited by 3 publications

References 20 publications

Clinical Application of a Customized 3D-Printed Bolus in Radiation Therapy for Distal Extremities

Clinical Application of a Customized 3D-Printed Bolus in Radiation Therapy for Distal Extremities

Dosimetric characteristics of a thin bolus made of variable shape tungsten rubber for photon radiotherapy

The development and characterization of an all-purpose bolus for radiotherapy

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