Example of a Thimerosal-Dependent Antibody without
Apparent Blood Group Specificity

Mason, James; Osborne, Pamela T.; Hall, A. Jane; Skolnik, Judy S.; Woods, Laura Lee; Wood, Catherine L.; Pierce, Steven J.; Beck, Malcolm L.

doi:10.1159/000465779

Cited by 5 publications

(6 citation statements)

References 1 publication

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“…It may also be produced by alloantibodies or autoantibodies whose detection requires the presence of drugs, such as caprylate (autoanti-e) [8], borate (anti-A) [9] ,chloramphenicol (anti-A,) [lo], paraben (autoanti-Jka) [ll], thimerosal (IgG autoantibody) [12], sodium azide (anti-I) [13], LISS (anti-Pr,) [14]. Drug-dependent antibodies without apparent group specificity have also been described [15], and some antidrug antibodies may adhere to the RBC surface by means of the Matuhasi-Ogata phenomenon…”

Section: Discussionmentioning

confidence: 99%

11‐Oxycorticosteroid‐Dependent Antibody in the Serum of a Patient with Bladder Neoplasm

Pinto

Fernández‐Fuertes

et al. 1992

Vox Sanguinis

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An IgM 11-oxycorticosteroid-dependent antibody was identified in the serum of a patient with bladder malignancy, which at 4-37 degrees C reacted with all the 11-oxycorticosteroids tested but not with desoxycorticosterone, testosterone, nortestosterone and progesterone. The resulting drug-antidrug antibody complex combines nonspecifically with red blood cells causing agglutination. This reactivity is enhanced both by acid pH and by high drug solution concentrations as well as by ficin test. The antibody is complement-independent and has no blood group specificity. No in vivo or in vitro hemolysis was observed.

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Section: Discussionmentioning

confidence: 99%

11‐Oxycorticosteroid‐Dependent Antibody in the Serum of a Patient with Bladder Neoplasm

Pinto

Fernández‐Fuertes

et al. 1992

Vox Sanguinis

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“…One of the least frequent causes of positive pretrans fusion tests is the presence in the patient's serum of anti bodies against chloramphenicol [5], neomycin [6], tetra cycline [3], hydrocortisone [7], which are often used as preservatives in the preparation of reagent RBCs. It may also be produced by alloantibodies or autoantibodies whose detection requires the presence of drugs, such as caprylate (autoanti-e) [8], borate (anti-A) [9],chloram phenicol (anti-Ai) [10], paraben (autoanti-Jk"') [11], thimerosal (IgG autoantibody) [12], sodium azide (anti-I) [13], LISS (anti-Pr,) [14], Drug-dependent antibodies without apparent group specificity have also been described [15], and some antidrug antibodies may adhere to the RBC surface by means of the Matuhasi-Ogata phenomenon yes ves ves yes yes ves…”

Section: Methodsmentioning

confidence: 99%

11-Oxycorticosteroid-Dependent Antibody in the Serum of a Patient with Bladder Neoplasm

Pinto¹,

Fernández‐Fuertes²,

C³

et al. 1992

Vox Sanguinis

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An IgM 11-oxycorticosteroid-dependent antibody was identified in the serum of a patient with bladder malignancy, which at 4-37 °C reacted with all the 11-oxycorticosteroids tested but not with desoxycorticosterone, testosterone, nortestosterone and progesterone. The resulting drug-antidrug antibody complex combines nonspecifically with red blood cells causing agglutination. This reactivity is enhanced both by acid pH and by high drug solution concentrations as well as by ficin test. The antibody is complement-independent and has no blood group specificity. No in vivo or in vitro hemolysis was observed.

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“…Thimerosal and paraben are LISS additives that have been implicated in this phenomenon. 1,[9][10][11][12][13] Antibody identification tests and the autocontrol should be repeated using a different potentiator such as polyethylene glycol (PEG). LISS-dependent reactivity should be reported when all cells including the autocontrol are reactive in the presence of one potentiator, but are nonreactive in the presence of others.…”

Section: Antibodies To Chemicals In Commercial Antibody Potentiatorsmentioning

confidence: 99%

How to recognize and resolve reagent-dependent reactivity: a review

et al. 2016

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Reagent-dependent reactivity can be described as agglutination of red blood cells (RBCs) in serologic testing that is not related to the interaction of RBC antigens and antibodies that the test system is intended to detect. In other words, reagent-dependent reactivity results in false-positive agglutination reactions in serologic testing. These false-positive reactions can cause confusion in antigen typing and RBC antibody detection and identification procedures, and may result in delays in patient transfusion. It is imperative that reagent-dependent reactivity is recognized and resolved during the investigation of ABO discrepancies, positive RBC antibody screens and antibody identification panels, and crossmatch reactivity. Immunohematology 2016;32:96-99.

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Example of a Thimerosal-Dependent Antibody without Apparent Blood Group Specificity

Cited by 5 publications

References 1 publication

11‐Oxycorticosteroid‐Dependent Antibody in the Serum of a Patient with Bladder Neoplasm

11‐Oxycorticosteroid‐Dependent Antibody in the Serum of a Patient with Bladder Neoplasm

11-Oxycorticosteroid-Dependent Antibody in the Serum of a Patient with Bladder Neoplasm

How to recognize and resolve reagent-dependent reactivity: a review

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