Examining Types of Fatigue Among Individuals with ME/CFS

Jason, Leonard A.; Jessen, Tricia; Porter, Nicole; Boulton, Aaron J.; Njoku, Mary Gloria C.

doi:10.18061/dsq.v29i3.938

Cited by 39 publications

(42 citation statements)

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“…PEM involves an abnormal response (e.g., an inappropriate loss of physical and mental stamina, rapid muscular and cognitive fatigability) following physical, cognitive, emotional, or orthostatic exertion [2,3,4]. The NIH/CDC CDE’s PEM working group recommended that PEM be assessed using a two-step process, with the first step involving five PEM items from the DePaul Symptom Questionnaire (DSQ) [5], and then a second step in which the clinician evaluates these responses in light of other information. Examples of other information could include other questions on the DSQ, the clinician’s own evaluation, previous medical records, other patient-reported scales, etc., to make a final decision regarding the assessment of PEM.…”

Section: Introductionmentioning

confidence: 99%

A Brief Questionnaire to Assess Post-Exertional Malaise

et al. 2018

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Post-exertional malaise (PEM) is a key symptom of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS). Currently, five PEM-items from the DePaul Symptom Questionnaire (DSQ) were recommended as a first step in measuring this symptom for patients with ME and CFS by the National Institutes of Health/Centers for Disease Control and Prevention (NIH/CDC) Common Data Elements’ (CDE) working group. The second step in this process, as recommended by the NIH/CDC CDE working group, involves assembling information from various sources to confirm the presence of PEM. There have not been any efforts, to date, to standardize this second-step process in the assessment of PEM. The current study examined whether five supplementary items on the DSQ could be used to operationalize the second step of the recommendations made by the NIH/CDC CDE working group. The five supplementary DSQ PEM duration items correctly categorized patients with ME or CFS 81.7% of the time, while incorrectly categorizing multiple sclerosis (MS) and post-polio syndrome (PPS) as ME or CFS only 16.6% of the time. The findings suggested that a PEM second-step process could be operationalized using supplementary DSQ items.

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Section: Introductionmentioning

confidence: 99%

A Brief Questionnaire to Assess Post-Exertional Malaise

et al. 2018

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“…The empiric CFS case definition (Reeves et al, 2005) estimates that 2.54% do have this illness, so that research group would suggest that almost all would fall within the CFS category. However, Jason et al (2009b) believe that within this 2.54% are mood disorders, which are one of the most prevalent psychiatric disorders (1 month prevalence rate of major depressive episode is 2.2%) (Regier et al, 1988). As an example, Major Depressive Disorder (MDD) can be confused with ME/CFS because it has some overlapping symptoms with the illness.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, Jason et al (2009b) developed the ME/CFS Fatigue Types Questionnaire (MFTQ), a 22 item scale designed to measure the duration, severity and frequency of different fatigue-related sensations and symptoms. The MFTQ appears to be a reliable and valid measure of fatigue types in individuals with ME/CFS.…”

Section: Post-exertional Malaise And/or Post-exertional Fatiguementioning

confidence: 99%

“…Jason et al (2010d) found that the post-exertional factor had adequate sensitivity and specificity (it was able to identify individuals who had ME/CFS and also exclude individuals who did not have this illness). Five items from the MFTQ with the highest loadings on the postexertional factor included: Dead, heavy feeling that occurs quickly after starting to exercise; next day soreness or fatigue after non-strenuous, everyday activities; mentally tired after the slightest effort; physically drained or sick after mild activity and minimum exercise makes you physically tired (Jason et al 2009b). We included these five items on the DePaul Symptom Questionnaire to measure postexertional malaise.…”

Section: Post-exertional Malaise And/or Post-exertional Fatiguementioning

confidence: 99%

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The Development of a Revised Canadian Myalgic Encephalomyelitis Chronic Fatigue Syndrome Case Definition

Jason

Evans

Porter

et al. 2010

American Journal of Biochemistry and Biotechnology

139

150

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Problem statement: Several investigators have indicated that case definitions for Chronic Fatigue Syndrome (CFS) are characterized by vaguely worded criteria that lack operational definitions and guidelines. The most widely used CFS case definition is the Fukuda et al. criteria, which uses polythetic criteria (i.e., patients are only required to have four out of a possible eight symptoms). Yet two of these eight symptoms (post-exertional malaise and memory/concentration problems) are an essential feature of this illness and the Fukuda et al. criteria do not require that these symptoms be present among all patients. Significant methodological problems could occur if investigators in different settings recruit samples with different percentages of these core symptoms. In contrast, the Canadian clinical case definition does require specific ME/CFS symptoms such as post-exertional malaise and memory/concentration problems. The provision of operationally explicit, objective criteria on specific key symptoms might reduce criterion variance as a source of unreliability. In addition, the use of structured interview schedules will ensure that symptoms are assessed in a consistent way across settings. Conclusion/Recommendations: In this article, we specified explicit rules for determining whether critical symptoms meet ME/CFS criteria using a revised Canadian case definition and a questionnaire has been developed to assess core symptoms. It is hoped that these developments will lead to increased reliability of this revised Canadian case definition as well as more frequent use of these criteria by investigators.

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“…An often used variant of the Chalder Fatigue Scale (CFQ) [7,8] contains 11 questions relate to 'fatigue' [9], e.g. "Do you lack energy?".…”

Section: Introductionmentioning

confidence: 99%

The effects of therapies for Myalgic Encephalomyelitis and chronic fatigue syndrome should be assessed using objective measures

Twisk¹

2017

Med Res Innov

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There is controversy with regard to therapies proposed to be effective for Myalgic Encephalomyelitis (ME) and chronic fatigue syndrome (CFS), especially behavorial therapies: cognitive behavioral therapy (CBT) and graded exercise therapy (GET). As will be exemplified by the PACE trial and other studies, the positive effects of CBT and GET are almost exclusively based on strongly varying subjective criteria (measures and cut-off thresholds for fatigue, physical functioning, et cetera). Depending on the subjective criteria used 'recovery' rates vary from 7% to 69%. Looking at the objective measures, e.g. work rehabilitation, physical fitness, and activity levels, CBT and GET seem to have a negligible effect or no effect at all. Trials into proposed therapies for ME and CFS, including CBT, GET, rituximab and rintatolimod, should use objective measures to impartially assess the effectiveness.

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Examining Types of Fatigue Among Individuals with ME/CFS

Cited by 39 publications

References 0 publications

A Brief Questionnaire to Assess Post-Exertional Malaise

A Brief Questionnaire to Assess Post-Exertional Malaise

The Development of a Revised Canadian Myalgic Encephalomyelitis Chronic Fatigue Syndrome Case Definition

The effects of therapies for Myalgic Encephalomyelitis and chronic fatigue syndrome should be assessed using objective measures

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