Examining the capacity of human U1 snRNA variants to facilitate pre-mRNA splicing
Jason Wong,
Ryan Yellamaty,
Christina Gallante
et al.
Abstract:The human U1 snRNA is encoded by a multigene family consisting of transcribed variants and defective pseudogenes. Many variant U1 (vU1) snRNAs have been demonstrated to not only be transcribed but also processed by the addition of a trimethylated guanosine cap, packaged into snRNPs, and assembled into spliceosomes, however, their capacity to facilitate pre-mRNA splicing has, so far, not been tested. A recent systematic analysis of the human snRNA genes identified 178 U1 snRNA genes that are present in the geno… Show more
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