Examining the association between grip strength and testosterone

Chiu, Hao-Tse; Shih, Mu-Tsun; Chen, Wei‐Liang

doi:10.1080/13685538.2019.1632282

Cited by 28 publications

(27 citation statements)

References 37 publications

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“…Likewise, because both passive smoking and grip strength have been associated with kidney function, we adjusted our models for glomerular filtration rate [30,31]. Finally, since there is some evidence suggesting that cotinine may inhibit testosterone breakdown [32], and low testosterone levels are associated with decreased muscle strength [33,34], we run models that additionally adjusted for serum testosterone concentrations [32].…”

Section: Discussionmentioning

confidence: 99%

Exposure to secondhand tobacco smoke is associated with reduced muscle strength in US adults

Carrasco-Rios

Ortolá

Rodríguez‐Artalejo

2019

Aging

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Secondhand tobacco smoke (SHS) exposure is a well-established risk factor for several diseases in adults. Despite the evidence that active tobacco smoke is harmful for the muscles, the association between SHS and muscle strength is still uncertain. We analyzed data from 5390 nonsmoking U.S. adults aged >30 years who participated in the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Exposure to SHS was assessed with serum cotinine concentrations. Grip strength was measured using a Takei digital handgrip dynamometer, and combined grip strength was calculated as the sum of the largest reading from each hand. Median (interquartile range) serum cotinine and grip strength were 0.015 ng/mL (IQR 0.011-0.36) and 65.5 kg (IQR 53.4-86.4), respectively. After adjusting for sociodemographic, anthropometric, health-related behavioral, and clinical risk factors, the highest (0.047-9.9 ng/mL) vs lowest (≤0.011 ng/mL) quartile of serum cotinine was associated with a reduction in combined grip strength of 1.41 kg (95%CI: -2.58, -0.24), p-trend=0.02. These results were consistent across socio-demographic and clinical subgroups. In the US nonsmoking adult population, even low levels of exposure to passive smoking were associated with decreased grip strength. Despite great achievements in tobacco control, extending public health interventions to reduce SHS exposure is still needed. SmokingNever 3730 (68.5) 0.

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Section: Discussionmentioning

confidence: 99%

Exposure to secondhand tobacco smoke is associated with reduced muscle strength in US adults

Carrasco-Rios

Ortolá

Rodríguez‐Artalejo

2019

Aging

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“…Regarding the inverse association between problem solving and the eGFR in men, we extensively searched correlates of problem solving, which may also affect the renal function, using data from a sub-cohort with relevant biological and physiological measurements 33 . As a result, we found that problem solving in men was significantly positively correlated with grip strength (age-adjusted ρ = 0.07 [ P < 0.001] based on 3384 male subjects, data not shown), which has been reported to be strongly associated with serum testosterone levels 34 . Since testosterone has been implicated in the deterioration of the renal function 35 , one possible explanation may be that men employing higher levels of problem solving tend to have higher testosterone levels, and thereby present a lower eGFR.…”

Section: Discussionmentioning

confidence: 75%

Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women

Koga

Hara

Shimanoe

et al. 2022

Sci Rep

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Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction = 0.003). Unexpectedly, problem solving in men (Ptrend < 0.001) and positive reappraisal in women (Ptrend = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.

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“…Regarding the inverse association between problem solving and the eGFR in men, we extensively searched correlates of problem solving, which may also affect the renal function, using data from a sub-cohort with relevant biological and physiological measurements 34 . As a result, we found that problem solving in men was signi cantly positively correlated with grip strength (age-adjusted r=0.07 [P<0.001] based on 3384 male subjects, data not shown), which has been reported to be strongly associated with serum testosterone levels 35 . Since testosterone has been implicated in the deterioration of the renal function 36 , one possible explanation may be that men employing higher levels of problem solving tend to have higher testosterone levels, and thereby present a lower eGFR.…”

Section: Discussionmentioning

confidence: 77%

Association of Perceived Stress And Coping Strategies With The Renal Function In Middle-Aged And Older Japanese Men And Women

Koga

Hara

Shimanoe

et al. 2021

Preprint

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Elucidating risk factors for chronic kidney disease is important for preventing end-stage kidney disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n=31,703) and women (n=38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend=0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction=0.003). Unexpectedly, problem solving in men (Ptrend<0.001) and positive reappraisal in women (Ptrend=0.002) also showed an inverse association with the eGFR. Perceived stress may affect eGFR, partly through the development of hypertension and diabetes. Based on the unexpected findings regarding coping strategies, further studies are required to clarify the underlying mechanisms, including the hormonal and immunological aspects.

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Examining the association between grip strength and testosterone

Cited by 28 publications

References 37 publications

Exposure to secondhand tobacco smoke is associated with reduced muscle strength in US adults

Exposure to secondhand tobacco smoke is associated with reduced muscle strength in US adults

Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women

Association of Perceived Stress And Coping Strategies With The Renal Function In Middle-Aged And Older Japanese Men And Women

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