Abstract:Accumulating evidence suggests glutamatergic hypofunction is one underlying factor in the pathology of schizophrenia. Administration of N‐methyl‐D‐aspartate receptor (NMDAR) antagonists induces psychotomimetic‐like symptoms in healthy humans and has emerged as a pharmacological model for symptoms of schizophrenia in animals. MK‐801, an NMDAR antagonist, is frequently used to disrupt cognition and induce hyperlocomotion, modelling the cognitive and positive symptoms of schizophrenia, respectively. However, desp… Show more
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