Examining racial differences in diffuse large B-cell lymphoma presentation and survival

Flowers, Christopher R.; Shenoy, Pareen J.; Borate, Uma; Bumpers, Kevin; Douglas-Holland, Tanyanika; King, Nassoma; Brawley, Otis W.; Lipscomb, Joseph; Lechowicz, Mary Jo; Sinha, Rajni; Grover, Rajinder S.; Bernal‐Mizrachi, Leon; Kowalski, Jeanne; Donnellan, Will; Reddy, Vishnu; Jaye, David L.; Foran, James M.

doi:10.3109/10428194.2012.708751

Cited by 48 publications

(58 citation statements)

References 41 publications

(55 reference statements)

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“…[20][21][22][23][24][25][26] Using the United States SEER data, we analyzed the relationships between patient demographics, presentation of disease, and overall survival in an attempt to identify which risk factors had the greatest influence on incidence and survival for MF/SS. Bradford et al utilized SEER data from 2001-2005 to examine incidence patterns for cutaneous lymphoma in the United States.…”

Section: Discussionmentioning

confidence: 99%

Incidence and survival patterns of cutaneous T-cell lymphomas in the United States

Imam

Shenoy

Flowers

et al. 2013

Leukemia & Lymphoma

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107

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Using the United States Surveillance, Epidemiology and End Results (SEER) 17 dataset, we examined incidence and survival patterns for patients with cutaneous T-cell lymphomas (CTCLs) diagnosed following institution of the World Health Organization-European Organisation for Research and Treatment of Cancer (WHO-EORTC) classification. From 2005 to 2008, 2273 cases of CTCL were diagnosed. The age-adjusted incidence rate per 100,000 person-years for mycosis fungoides (MF) was 0.55 and for Sézary syndrome (SS) was 0.01. Incidence was higher among males (MF/SS male-to-female incidence rate ratio [IRR] 1.57) and black patients (MF black-to-white IRR 1.55). Black patients with CTCL were diagnosed at a younger age and black patients with MF/SS presented with advanced stage and had worse survival than white patients. In multiple-variable Cox-regression models, age > 60 (hazard ratio [HR] 4.78, 95% confidence interval [CI] 2.97-7.70), black race (HR 2.09, 95% CI 1.29-3.37) and advanced stage (HR 6.06, 95% CI 3.66-10.05) predicted worse survival for patients with MF/SS. Additional research identifying reasons for these differences are necessary to better understand these diseases and for new strategies in the treatment of CTCL.

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Section: Discussionmentioning

confidence: 99%

Incidence and survival patterns of cutaneous T-cell lymphomas in the United States

Imam

Shenoy

Flowers

et al. 2013

Leukemia & Lymphoma

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107

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“…on May 12, 2018. by guest www.bloodjournal.org From Previous studies have found African-American DLBCL patients to have risks of death 10% to 20% higher than those for non-Hispanic whites, 7,[11][12][13] with survival differences persisting after the introduction of rituximab. 7,11,12 Specifically, Komrokji reported that the median overall survival after diagnosis of DLBCL was 47 months in white patients vs 29 months in African-American patients from 2000 to 2004.…”

Section: Discussionmentioning

confidence: 99%

“…6 Despite these advances in treatment, African-American patients were reported to have risks of death 10% to 20% higher than nonHispanic whites after DLBCL. 7,[11][12][13] SEER-Medicare analyses including patients treated predominantly in the CHOP era have suggested that delayed therapy or socioeconomic factors (specifically poverty, education, and family income) partially explain these results. 11,14 However, no studies have considered how neighborhood socioeconomic status (SES) influences these racial/ethnic disparities in DLBCL despite SES being an important cancer prognostic factor [15][16][17][18] and often underlying the associations between race/ethnicity and poor health outcomes.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic disparities in mortality after diffuse large B-cell lymphoma in the modern treatment era

Foran

Clarke

et al. 2014

Blood

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“…Racial differences have been studied for multiple cancer types, including NHL overall and individual subtypes [7,8,9,10,11]. However, the existing studies may be limited by focusing on a specific subtype (for example, some studies [8] focus on DLBCL only), a narrow spectrum of racial groups (for example, Koshiol et al [12] only compared whites and blacks), or specific outcomes (for example, treatment and survival [8]).…”

Section: Introductionmentioning

confidence: 99%

Racial differences in three major NHL subtypes: Descriptive epidemiology

Wang

et al. 2015

Cancer Epidemiology

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Background NHL (non-Hodgkin lymphoma) consists of over 60 subtypes, ranging from slow-growing to very aggressive. The three largest subtypes are DLBCL (diffuse large B-cell lymphoma), FL (follicular lymphoma), and CLL/SLL (chronic lymphocytic leukemia/small lymphocytic lymphoma). For each subtype, different racial groups have different presentations, etiologies, and prognosis patterns. Methods SEER (Surveillance, Epidemiology, and End Results) data on DLBCL, FL, and CLL/SLL patients diagnosed between 1992 and 2010 were analyzed. Racial groups studied included NHW (non-Hispanic whites), HW (Hispanic whites), blacks, and API (Asians and Pacific Islanders). Patient characteristics, age-adjusted incidence rate, and survival were compared across races. Stratification and multivariate analysis were conducted. Results There are significant racial differences for patients’ characteristics, including gender, age at diagnosis, stage, lymph site, and age, and the patterns vary across subtypes. NHWs have the highest incidence rates for all three subtypes, followed by HWs (DLBCL and FL) and blacks (CLL/SLL). The dependence of the incidence rate on age and gender varies across subtypes. For all three subtypes, NHWs have the highest five-year relative survival rates, followed by HWs. When stratified by stage, racial difference is significant in multiple multivariate Cox regression analyses. Conclusions Racial differences exist among DLBCL, FL, and CLL/SLL patients in the U.S. in terms of characteristics, incidence, and survival. The patterns vary across subtypes. More data collection and analysis are needed to more comprehensively describe and interpret the across-race and subtype differences.

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Examining racial differences in diffuse large B-cell lymphoma presentation and survival

Cited by 48 publications

References 41 publications

Incidence and survival patterns of cutaneous T-cell lymphomas in the United States

Incidence and survival patterns of cutaneous T-cell lymphomas in the United States

Socioeconomic disparities in mortality after diffuse large B-cell lymphoma in the modern treatment era

Racial differences in three major NHL subtypes: Descriptive epidemiology

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