Examining how and why polygenic dopamine composite levels moderate adolescents’ vulnerability to peer victimization

Abstract

Extensive literature documents that dopaminergic genes play an important role in the link between adverse environments and adolescents’ problem behavior. However, little is known about the potential mechanism underlying adolescents’ vulnerability to peer victimization. The current study examined the effect of the interplay between a polygenic dopamine composite (i.e., COMT Val158Met and DRD2-141C Ins/Del polymorphisms) and peer victimization on adolescents’ externalizing problems as well as the mediating role of emotion dysregulation in the interactive effects in a sample of 393 Chinese adolescents (Mean age = 14.71 years; 50.1% girls). A significant moderation of dopaminergic genetic composite was observed in girls but not in boys. In addition, emotion dysregulation partially explained the moderating effect of dopaminergic genes. Specifically, girls with genic composite indexing low dopamine activity reported a higher level of emotion dysregulation when faced with more peer victimization. More difficulties with emotion regulation, in turn, predicted more pronounced externalizing problems in girls. This study underscores polygenic underpinnings of adolescent vulnerability to negative peer experiences and suggests the importance of considering sex differences when investigating genic influence on the relationship between adverse environments and externalizing problems.

The impact of dopamine receptor D4, temperamental negativity, and household chaos on young twins’ externalizing behaviors

“…Other work, using a polygenic dopamine composite score, demonstrated that dopaminergic genes moderated adolescent vulnerability to adverse social factors (e.g., peer victimization), via emotional dysregulation (in girls but not boys). Specifically, compared with individuals with composite scores indicative of greater dopamine activity, adolescents with lower dopamine activity reported higher levels of emotional dysregulation when facing victimization and, in turn, displayed more externalizing (Gao et al., 2022). Together, these studies suggest that dopaminergic differences may be salient factors in determining individual sensitivity and responsiveness to environmental circumstances.…”