Examining external control arms in oncology: A scoping review of applications to date
Eliya Farah,
Matthew Kenney,
Matthew T. Warkentin
et al.
Abstract:ObjectivesRandomized controlled trials (RCTs) are the gold standard for evaluating the comparative efficacy and safety of new cancer therapies. However, enrolling patients in control arms of clinical trials can be challenging for rare cancers, particularly in the context of precision oncology and targeted therapies. External Control Arms (ECAs) are a potential solution to address these challenges in clinical research design. We conducted a scoping review to explore the use of ECAs in oncology.MethodsWe systema… Show more
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