Examining Efficacy of Kidney-Targeted Nanoparticle Immunosuppressant Therapy on Lupus Nephritis in a Murine Autoimmune Disease Model
Katinka Miklossy
Abstract:Introduction: Lupus nephritis (LN) is a severe kidney manifestation of systematic lupus erythematosus (SLE) with no known cure. Although typically treated with immunosuppressants, these medications can cause toxic side effects. This study proposes adopting mesoporous silica nanoparticles binding to a kidney-specific ligand, megalin, to locally deliver the immunosuppressive agent with no nephrotoxicity, mycophenolate mofetil. It is hypothesized that this method would inhibit LN progression by locally modulating… Show more
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