Examining age‐related differences in functional domain impairment following traumatic brain injury

Cheng, Sunny Chieh; Chi, Nai-Ching; Williams, Ellita T.; Thompson, Hilaire J.

doi:10.1111/opn.12208

Cited by 8 publications

(2 citation statements)

References 22 publications

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“…In a clinical setting, TBI varies in injury mechanism and severity, as well as pre-injury vulnerabilities such as age, sex, and genetic factors [ 4 ]. Pre-injury vulnerabilities, or even the presence of other concurrent factors such as infection, may alter TBI pathophysiology and outcomes [ 5 , 10 , 25 – 27 ]. On the other hand, preclinical animal models, which ultimately provide the foundation for clinical trials, are highly homogenous as they typically utilize isolated TBI platforms that often fail to incorporate the heterogeneity of the clinical population [ 4 ].…”

Section: Traumatic Brain Injurymentioning

confidence: 99%

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Baker

Sun

Semple

et al. 2020

J Neuroinflammation

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Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is hindered by the heterogenous nature of TBI presentation and pathophysiology. In particular, the degree of neuroinflammation after TBI varies between individuals and may be modified by other factors such as infection. Toxoplasma gondii, a parasite that infects approximately one-third of the world's population, has a tropism for brain tissue and can persist as a lifelong infection. Importantly, there is notable overlap in the pathophysiology between TBI and T. gondii infection, including neuroinflammation. This paper will review current understandings of the clinical problems, pathophysiological mechanisms, and functional outcomes of TBI and T. gondii, before considering the potential synergy between the two conditions. In particular, the discussion will focus on neuroinflammatory processes such as microglial activation, inflammatory cytokines, and peripheral immune cell recruitment that occur during T. gondii infection and after TBI. We will present the notion that these overlapping pathologies in TBI individuals with a chronic T. gondii infection have the strong potential to exacerbate neuroinflammation and related brain damage, leading to amplified functional deficits. The impact of chronic T. gondii infection on TBI should therefore be investigated in both preclinical and clinical studies as the possible interplay could influence treatment strategies.

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Section: Traumatic Brain Injurymentioning

confidence: 99%

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Baker

Sun

Semple

et al. 2020

J Neuroinflammation

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“…Individuals who have sustained traumatic brain injury (TBI) often demonstrate gait impairments that are associated with paralysis, muscular atrophy, compromised motor control, and muscular contracture (Acuña, Tyler, Danilov, & Thelen, ; Lorenz, Charrette, O'Neil‐Pirozzi, Doucett, & Fong, ; Perez, Green, & Mochizuki, ). Limited mobility can also affect the independence of activities of daily living and quality of life (Cheng, Chi, Williams, & Thompson, ; Ptyushkin, Cieza, & Stucki, ).…”

Section: Introductionmentioning

confidence: 99%

Aquatic treadmill walking at three depths of water in people with traumatic brain injury

Narasaki‐Jara

Wagatsuma

Holt

et al. 2019

Physiotherapy Res Intl

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Objective The purpose of this study was to analyse kinematic and spatiotemporal gait characteristics of aquatic treadmill walking among three different depths of water in individuals with traumatic brain injury. Methods A total of 13 individuals with traumatic brain injury participated in the study and completed walking trials at three different depths as follows: waist, chest, and neck level, which was adjusted by a movable floor pool. A self‐selected comfortable walking speed at the waist level was used as a matched speed for all walking trials. Participants completed three aquatic treadmill walking trials under each of the three water depths. Each participant's gait was captured by a customized underwater motion analysis system and processed by a two‐dimensional motion analysis software. Results The repeated measures analysis of variance showed significant differences in spatiotemporal and joint kinematic variables across three conditions: stance swing ratio (p = .023), peak hip flexion (p = .001), hip range of motion (p = .047), and peak ankle dorsiflexion (p = .000). Various water properties in conjunction with motor impairments might have contributed to alterations in gait kinematics. Conclusion Our findings suggest that walking in neck‐depth water may not be ideal for gait training as it appears to limit hip flexion and ankle dorsiflexion. It is recommended that waist to chest‐depth water be used to provide an accommodating environment for aquatic gait rehabilitation.

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Geriatric Considerations: Age-Related Functional Changes in Acquired Neurologic Injury

Pinto

2024

Acute Care Neuroconsultation and Neurorehabilitation Management

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Examining age‐related differences in functional domain impairment following traumatic brain injury

Abstract: Early intervention and rehabilitation should focus on improving older adults' physical functioning and mobility. Our study may also inform future research and design of post-TBI interventions for older adults.

Cited by 8 publications

References 22 publications

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Aquatic treadmill walking at three depths of water in people with traumatic brain injury

Geriatric Considerations: Age-Related Functional Changes in Acquired Neurologic Injury

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