Examining a transdiagnostic measure of repetitive thinking in depressed, formerly depressed and never-depressed individuals

Samtani, Suraj; McEvoy, Peter M.; Mahoney, Alison; Werner‐Seidler, Aliza; Li, Susan S. Y.; McGill, Brittany C.; Tockar, Julia; Moulds, Michelle L.

doi:10.1016/j.jad.2017.12.081

Cited by 10 publications

(16 citation statements)

References 24 publications

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“…The transdiagnostic construct was demonstrated across all clinical conditions investigated only in a minority (34%) of studies. It was demonstrated in a median of three conditions and one spectrum.…”

Section: Resultsmentioning

confidence: 93%

“…The number of primary mental disorders investigated by each study was highly variable and overall relatively low, ranging from no evidence of mental disorders at all (13% of studies) and one mental disorder (8% of studies), up to 353 mental disorders (median: four mental disorders per study). Similarly, the number of ICD‐defined diagnostic spectra was heterogeneous, ranging from zero (12% of studies) to ten (median: one spectrum) per study.…”

Section: Resultsmentioning

confidence: 99%

“…Less than half (44%) of the studies performed a statistical comparative assessment of the transdiagnostic approach versus a specific‐diagnostic approach. This problem was particularly relevant for interventional studies, half of which lacked a comparative specific‐diagnostic group.…”

Section: Resultsmentioning

confidence: 99%

“…The qualitative appraisal of the transdiagnostic vs. specific‐diagnostic effects – when available – revealed further inconsistencies. For example, some predictive modelling studies indicated that the transdiagnostic approach was only able to explain an additional 1% of the variance. Other studies acknowledged that the observed transdiagnostic effects were small in magnitude, but at the same time suggested developing transdiagnostic clinical interventions.…”

Section: Resultsmentioning

confidence: 99%

“…A substantial proportion of studies (40%) did not acknowledge an a priori protocol. There were very few studies reporting industry involvement (4%).…”

Section: Resultsmentioning

confidence: 99%

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Transdiagnostic psychiatry: a systematic review

et al. 2019

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The usefulness of current psychiatric classification, which is based on ICD/DSM categorical diagnoses, remains questionable. A promising alternative has been put forward as the "transdiagnostic" approach. This is expected to cut across existing categorical diagnoses and go beyond them, to improve the way we classify and treat mental disorders. This systematic review explores whether self-defining transdiagnostic research meets such high expectations. A multi-step Web of Science literature search was performed according to an a priori protocol, to identify all studies that used the word "transdiagnostic" in their title, up to May 5, 2018. Empirical variables which indexed core characteristics were extracted, complemented by a bibliometric and conceptual analysis. A total of 111 studies were included. Most studies were investigating interventions, followed by cognition and psychological processes, and neuroscientific topics. Their samples ranged from 15 to 91,199 (median 148) participants, with a mean age from 10 to more than 60 (median 33) years. There were several methodological inconsistencies relating to the definition of the gold standard (DSM/ICD diagnoses), of the outcome measures and of the transdiagnostic approach. The quality of the studies was generally low and only a few findings were externally replicated. The majority of studies tested transdiagnostic features cutting across different diagnoses, and only a few tested new classification systems beyond the existing diagnoses. About one fifth of the studies were not transdiagnostic at all, because they investigated symptoms and not disorders, a single disorder, or because there was no diagnostic information. The bibliometric analysis revealed that transdiagnostic research largely restricted its focus to anxiety and depressive disorders. The conceptual analysis showed that transdiagnostic research is grounded more on rediscoveries than on true innovations, and that it is affected by some conceptual biases. To date, transdiagnostic approaches have not delivered a credible paradigm shift that can impact classification and clinical care. Practical "TRANSD"iagnostic recommendations are proposed here to guide future research in this field.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…A substantial proportion of studies (40%) did not acknowledge an a priori protocol. There were very few studies reporting industry involvement (4%).…”

Section: Resultsmentioning

confidence: 99%

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Transdiagnostic psychiatry: a systematic review

et al. 2019

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Transdiagnostic View on Worrying and Other Negative Mental Content

Ehring

Behar

2020

Generalized Anxiety Disorder and Worrying

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Resting state functional connectivity correlates of rumination and worry in internalizing psychopathologies

Feurer

Jimmy

Chang

et al. 2021

Depression and Anxiety

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Background: Rumination and worry are repetitive negative thinking (RNT) tendencies that contribute to the development and maintenance of internalizing psychopathologies. Accruing data suggest rumination and worry represent overlapping and unique transdiagnostic cognitive processes. Yet, prior neuroimaging research has mostly focused on rumination in depression, which points to involvement of resting-state brain activity in default mode, executive, salience, and/or affective networks.Methods: The current study examined relations between brain activity during rest and RNT in a transdiagnostic sample. Resting-state fMRI data was analyzed in 80 unmedicated patients with internalizing conditions. Regression analysis, controlling for anxiety and depression symptoms, was performed with seed regions implicated in default mode, executive, salience, and affective networks.Rumination and worry were assessed with standard self-report measures.Results: Whole-brain regression results showed more rumination and worry jointly corresponded with greater positive resting-state functional connectivity (rsFC) between the amygdala and prefrontal regions (i.e., middle frontal gyrus, inferior frontal gyrus). Conversely, more worry (controlling for rumination) corresponded with greater negative rsFC between amygdala and precuneus.No significant results were observed for rumination alone (controlling for worry).Conclusions: Findings indicate the affective network plays a role in RNT, and distinct patterns of connectivity between amygdala and regions implicated in the executive and default mode networks were observed across patients with internalizing conditions. Results suggest different mechanisms contribute to RNT as a unitary construct and worry as a unique construct.

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Examining a transdiagnostic measure of repetitive thinking in depressed, formerly depressed and never-depressed individuals

Cited by 10 publications

References 24 publications

Transdiagnostic psychiatry: a systematic review

Transdiagnostic psychiatry: a systematic review

Transdiagnostic View on Worrying and Other Negative Mental Content

Resting state functional connectivity correlates of rumination and worry in internalizing psychopathologies

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