Examination techniques

Trichopoulos, Nikolaos; Damato, Bertil

doi:10.1016/b978-1-4160-3167-3.50036-x

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Transillumination is commonly used for the diagnosis and localisation of uveal melanoma and other intraocular tumours, especially for anteriorly located lesions, which are not visible on slit lamp examination 1. For photographic documentation, however, the technique is less suitable, as the low light intensity usually leads to dark and blurred images.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared transillumination photography of intraocular tumours

2013

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Section: Introductionmentioning

confidence: 99%

Near-infrared transillumination photography of intraocular tumours

2013

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“…Transillumination is a simple and commonly used technique for the diagnosis and localisation of intraocular tumours 1. Cystic or atrophic lesions may transilluminate, while pigmented tumours such as uveal melanomas usually block the light.…”

Section: Introductionmentioning

confidence: 99%

A modified digital slit lamp camera system for transillumination photography of intraocular tumours

Krohn

Kjersem

2011

Br J Ophthalmol

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“…The first step is to locate the intraocular tumor, which for anteriorly located tumors can be achieved relatively easily by transpupillary or transocular transillumination. 2 Melanincontaining tumor tissue absorbs the transilluminated light and casts a distinct shadow onto the eyewall so that its margin can be marked on the episclera. For more posteriorly located tumors, however, the procedure is more complicated, necessitating the use of indirect ophthalmoscopy combined with scleral depression or transscleral transillumination.…”

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confidence: 99%

Cerenkov Luminescence Imaging for Accurate Placement of Radioactive Plaques in Episcleral Brachytherapy of Intraocular Tumors

Axelsson

Krohn

2015

Invest. Ophthalmol. Vis. Sci.

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Citation: Axelsson J, Krohn J. Cerenkov luminescence imaging for accurate placement of radioactive plaques in episcleral brachytherapy of intraocular tumors. Invest Ophthalmol Vis Sci. 2015;56:7362-7368. DOI:10.1167/iovs.15-18012 PURPOSE. The purpose of this study was to determine the feasibility of using Cerenkov luminescence imaging (CLI) to facilitate plaque placement during episcleral brachytherapy of intraocular tumors.METHODS. Ruthenium-106 (Ru-106) decays to rhodium-106, which in turn emits high-energy beta particles. When the electrons propagate through the eyewall, the so-called Cerenkov effect leads to emission of weak light, which can be captured by high-sensitivity chargecouple device (CCD) cameras. Enucleated porcine eyes were prepared with tumor phantoms made of melanin-containing gelatin. The anterior portion of the globe was removed, and different Ru-106 plaque types (designated CCA, CCB, COB, and CIA) with activities ranging from 6.8 to 16.7 MBq were sutured to the sclera overlying the tumor phantom. The globe was placed in a transparent container with saline. CLI was performed through the anterior opening of the eye using a cooled electron-multiplying CCD camera. RESULTS.Exposure times between 5 and 60 seconds produced good quality images of the Cerenkov light. There was a linear relationship between plaque activity and Cerenkov radiance. The perimeters of the CCA and CCB plaques could be seen clearly as circles of light symmetrically surrounding the tumor phantoms. Notched COB and CIA plaques led to images revealing their actual positions in relation to the optic disc and ciliary body, respectively. Simulated plaque tilting resulted in diffuse demarcation of the light.CONCLUSIONS. The study indicates that CLI is a feasible method to ensure accurate placement of Ru-106 plaques in brachytherapy of intraocular tumors. CLI may offer a new tool to improve and document plaque placement, both perioperatively and postoperatively.

show abstract

Examination techniques

Cited by 5 publications

References 13 publications

Near-infrared transillumination photography of intraocular tumours

Near-infrared transillumination photography of intraocular tumours

A modified digital slit lamp camera system for transillumination photography of intraocular tumours

Cerenkov Luminescence Imaging for Accurate Placement of Radioactive Plaques in Episcleral Brachytherapy of Intraocular Tumors

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