Generalized mean-field approach for thermodynamic description of relativistic single-and multicomponent gas in the grand canonical ensemble is formulated. In the framework of the proposed approach different phenomenological excluded-volume procedures are presented and compared to the existing ones. The mean-field approach is then used to effectively include hard-core repulsion in hadron-resonance gas model for description of chemical freeze-out in heavy-ion collisions. We calculate the collision energy dependence of several quantities for different values of hard-core hadron radius and for different excluded-volume procedures such as the van der Waals and Carnahan-Starling models. It is shown that a choice of the excluded-volume model becomes important for large particle densities. For large enough values of hadron radii (r 0.9 fm) there can be a sizable difference between different excluded-volume procedures used to describe the chemical freeze-out in heavy-ion collisions. At the same time, for the smaller and more commonly used values of hardcore hadron radii (r 0.5 fm), the precision of the van der Waals excluded-volume procedure is shown to be sufficient.