Examination of the role of resveratrol in attenuating oxidative damage induced by starvation stress in the marine mussel, Mytilus coruscus, through regulation of the sirt1-mediated signaling pathway

Chen, Chuanyue; Xie, Bing; Sun, Wenjing; Gu, Zemao; Huang, Ji; Qi, Pengzhi; Liao, Zhi; Zhang, Xiaolin

doi:10.1016/j.aquaculture.2022.739047

Cited by 6 publications

(2 citation statements)

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“…The KEGG analysis of peaks showed a predominant enrichment in the FoxO, mTOR, and p53 signaling pathway. The FoxO signaling pathway has been found to be involved in various aspects, including lifespan regulation, growth and development, as well as resistance to starvation and environmental stressors (Xiao et al, 2018;Wang et al, 2021a;Chen et al, 2023). Considering that Nrf2 acts as a crucial trigger for the body's antioxidant defense mechanisms, the significant association between McNrf2 and FoxO implies that when M. coruscus mussels face oxidative stress, the activation of the FoxO pathway regulates growth and development, ultimately ensuring the maintenance of normal life activities.…”

Section: Discussionmentioning

confidence: 99%

ChIP-seq identifies McSLC35E2 as a novel target gene of McNrf2 in Mytilus coruscus, highlighting its role in the regulation of oxidative stress response in marine mollusks

Qiu,

Chen,

Zhu

et al. 2023

Front. Physiol.

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NF-E2-related factor 2 (Nrf2) plays a crucial role in the oxidative regulatory process, which could trigger hundreds of antioxidant elements to confront xenobiotics. In the previous study, we identified Nrf2 from the marine mussel Mytilus coruscus, and the findings demonstrated that McNrf2 effectively protected the mussels against oxidative stress induced by benzopyrene (Bap). In order to delve deeper into the underlying mechanism, we utilized Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) technology to systematically identify potential novel target genes of McNrf2. A total of 3,465 potential target genes were screened, of which 219 owned binding sites located within the promoter region. During subsequent experimental verification, it was found that McSLC35E2, a candidate target gene of McNrf2, exhibited negative regulation by McNrf2, as confirmed through dual luciferase and qRT-PCR detection. Further, the enzyme activity tests demonstrated that McNrf2 could counteract Bap induced oxidative stress by inhibiting McSLC35E2. The current study provides valuable insights into the application of ChIP-seq technology in the research of marine mollusks, advancing our understanding of the key role of Nrf2 in antioxidant defense mechanisms, and highlighting the significance of SLC35E2 in the highly sophisticated regulation of oxidative stress response in marine invertebrates.

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Section: Discussionmentioning

confidence: 99%

ChIP-seq identifies McSLC35E2 as a novel target gene of McNrf2 in Mytilus coruscus, highlighting its role in the regulation of oxidative stress response in marine mollusks

Qiu,

Chen,

Zhu

et al. 2023

Front. Physiol.

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“…In both the gills and muscle, miRNAs regulate the FoxO signaling pathway, which plays a crucial role in individual development, cell proliferation, stress response, and metabolism in bivalves [57,58].…”

Section: Muscle-specific Mirna and Target Gene Functionsmentioning

confidence: 99%

microRNA-mRNA Analysis Reveals Tissue-Specific Regulation of microRNA in Mangrove Clam (Geloina erosa)

Liu,

Dong,

Chen

et al. 2023

Biology

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Geloina erosa is an important benthic animal in the mangrove, serving as an indicator organism for coastal environmental pollution. This study aimed to investigate the tissue-specific expression of miRNAs and their regulatory roles in predicted targets in G. erosa. Through miRNA sequencing and co-expression network analysis, we extensively studied the miRNA expression in three tissues: gills, hepatopancreas, and muscle. The results revealed a total of 1412 miRNAs, comprising 1047 known miRNAs, and 365 newly predicted miRNAs. These miRNAs exhibited distinct tissue-specific expression patterns. In the miRNA target gene prediction, a total of 7404 potential predicted targets were identified, representing approximately 33% of all unique transcripts associated with miRNAs. Further co-expression network analysis revealed nine modules, each showing a positive correlation with specific tissues (gills, hepatopancreas, or muscle). The blue module showed a significant correlation with gills (r = 0.83, p-value = 0.006), the black module was significantly related to the hepatopancreas (r = 0.78, p-value = 0.01), and the purple module was significantly correlated with muscle (r = 0.83, p-value = 0.006). Within these modules, related miRNAs tended to cluster together, while their correlations with other modules were relatively weak. Functional enrichment analysis was performed on miRNAs and their predicted targets in each tissue. In the gills, miRNAs primarily regulate immune-related genes, substance transport, and cytoskeletal organization. In the hepatopancreas, miRNAs suppressed genes involved in shell formation and played a role in cellular motor activity and metabolism. In muscle, miRNAs participate in metabolism and photoreceptive processes, as well as immune regulation. In summary, this study provides valuable insights into the tissue-specific regulation of miRNAs in G. erosa, highlighting their potential roles in immune response, metabolism, and environmental adaptation. These findings offer important clues for understanding the molecular mechanisms and biological processes in G. erosa, laying the foundation for further validation and elucidation of these regulatory relationships.

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Effects of Starvation and Refeeding on Glucose Metabolism and Immune Responses in Macrobrachium rosenbergii

Jiang

et al. 2023

Mar Biotechnol

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Examination of the role of resveratrol in attenuating oxidative damage induced by starvation stress in the marine mussel, Mytilus coruscus, through regulation of the sirt1-mediated signaling pathway

Cited by 6 publications

References 53 publications

ChIP-seq identifies McSLC35E2 as a novel target gene of McNrf2 in Mytilus coruscus, highlighting its role in the regulation of oxidative stress response in marine mollusks

ChIP-seq identifies McSLC35E2 as a novel target gene of McNrf2 in Mytilus coruscus, highlighting its role in the regulation of oxidative stress response in marine mollusks

microRNA-mRNA Analysis Reveals Tissue-Specific Regulation of microRNA in Mangrove Clam (Geloina erosa)

Effects of Starvation and Refeeding on Glucose Metabolism and Immune Responses in Macrobrachium rosenbergii

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