Examination of the Physical Chemical Basis for the Isoniazid- p -Aminosalicylic Acid Combination * *School of Pharmacy, University of Wisconsin, Madison

Introduction to Biopharmaceutics and its Role in Drug Development

“…Essentially, physical pharmacy is a collection of basic chemistry concepts that are firmly rooted in thermodynamics and chemical kinetics. Scientists in the mid-twentieth century pioneered research in the areas of physical-chemical properties of drugs and their influence on biological performance (Reinstein and Higuchi, 1958;Higuchi, 1958Higuchi, , 1976Higuchi et al, 1956Higuchi et al, , 1958Higuchi et al, , 1963Kostenbauder and Higuchi, 1957;Shefter and Higuchi, 1963;Agharkar et al, 1976;Shek et al, 1976). Key aspects of physical-chemical properties discussed in greater detail in Chap.…”