Examination of the peripheral nerve and muscle damage in cyclophosphamide monotherapy with DSC in animal models

Farkas, Péter; Könczöl, Franciska; Lőrinczy, D.

doi:10.1007/s10973-016-5253-9

Cited by 8 publications

(12 citation statements)

References 20 publications

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“…haematologic malignancies and in each type of solid tumours, etc. [1]. It is the reason that appeared on the most important drugs' list published by WHO in April, 2015 [2].…”

Section: Introductionmentioning

confidence: 99%

“…It is the reason that appeared on the most important drugs' list published by WHO in April, 2015 [2]. It is a good tool during polyneuropathy treatment, but in several cases, it can induct this disorder too [1].…”

Section: Introductionmentioning

confidence: 99%

“…Any damage or unexpected changes in protein structure caused by chemotherapeutic agents in any step will cause a malfunction. It was shown in animal model that the cyclophosphamide can cause dose-dependent effect in the thermal characteristic of nerve, different muscles as well as in different blood compounds (plasma, red blood cell) [1,[3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Cyclophosphamide treatment evoked side effects on skeletal muscle monitored by DSC

Lőrinczy

2020

J Therm Anal Calorim

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Polyneuropathy is defined as a simultaneous malfunction of several peripheral nerves, which could be a side effect of cancer therapy as well. Many kinds of drugs, supposedly cyclophosphamide, also can induce a disease classified as toxic polyneuropathy. It is well known that a severe problem in the locomotor activity can join to it. Recently, we have no enough information about the attacked points in the structure of muscle proteins, as well as about the change in the interaction of myosin actin. In the present study, we analyse this side effect on skeletal muscle (m. gastrocnemius) by differential scanning calorimetry (DSC), as an established thermal analysis method, to follow the possible consequence of drug treatment in the most important muscle protein. We used cyclophosphamide-treated in vitro animal model (guinea pig) with a comparable dosage and time handling of human protocol to show evidences of this drug-induced effects. According to our results, we could show a dose-dependent difference between thermal parameters (denaturation temperature and calorimetric enthalpy) of untreated and treated samples assigned to their contractile proteins (actin and myosin), which can be detected by DSC. It proved that we can create new possibilities in the detection and prognosis of expected and unwanted side effects of cyclophosphamide, such as change of locomotor activity joined to polyneuropathy.

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“…haematologic malignancies and in each type of solid tumours, etc. [1]. It is the reason that appeared on the most important drugs' list published by WHO in April, 2015 [2].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cyclophosphamide treatment evoked side effects on skeletal muscle monitored by DSC

Lőrinczy

2020

J Therm Anal Calorim

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“…Because of this, it is possible to conclude short-and long-term effects in a predictive way. This paper is a comment on paper published by Farkas et al 1 Our team were examined the effects of cyclophosphamide-which is a widely used cytotoxic drug and appears on the most important drugs' list made by WHO-on guinea pigs equivalent to human protocol in experimental conditions. Cyclophosphamide is a very effective immunosuppressive drug-used primarily in severe immunological diseases associated with organ involvement such as scleroderma, vasculitis, SLE and also used in organ transplantations.…”

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confidence: 99%

“…1 The analyses were made by the SETARAM Micro DSC-II calorimeter. According to our results, we could show a significant, dose-dependent difference between thermal parameters (T m D denaturation temperature, DH D calorimetric enthalpy, not marked) of untreated and treated samples, which proved that cyclophosphamide has got a peripheral and in smaller degree of cases muscle damage effect (see Fig.…”

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confidence: 99%

New possibilities of application of differential scanning calorimetry—new clinical diagnostic methods on the horizon?

Farkas

Lőrinczy

2017

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Thermal analysis in biological and medical applications

Lőrinczy

2017

J Therm Anal Calorim

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Examination of the peripheral nerve and muscle damage in cyclophosphamide monotherapy with DSC in animal models

Cited by 8 publications

References 20 publications

Cyclophosphamide treatment evoked side effects on skeletal muscle monitored by DSC

Cyclophosphamide treatment evoked side effects on skeletal muscle monitored by DSC

New possibilities of application of differential scanning calorimetry—new clinical diagnostic methods on the horizon?

Thermal analysis in biological and medical applications

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