Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

Papanastasiou, Evangelos; Mouchlianitis, Elias; Joyce, Dan W.; McGuire, Philip; Boussebaa, Celia; Banaschewski, Tobias; Bokde, Arun L.W.; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Spechler, Philip A.; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Marie Laure Paillère; Artiges, Éric; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Günter; Shergill, Sukhwinder S.

doi:10.1038/s41598-020-62026-7

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…Similar to patients with psychosis, studies conducted on this population have highlighted abnormal self-and bodily experiences, sleep dysfunction, and impaired social cognition (Andorko et al, 2017;Barragan et al, 2011;Gawęda et al, 2019;Graham et al, 2015;Pionke et al, 2020). Abnormal functioning of the insular cortex has also been reported (Papanastasiou et al, 2020), suggesting that interoception is likely an area worthy of investigation. Specifically, assessing individuals' tendency to focus on, worry about, and react to internal bodily changes (i.e., interoceptive sensibility), may help highlight maladaptive attentional styles (Mehling, 2016) potentially contributing to the development of psychotic symptoms, with important implications for early detection and treatment.…”

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confidence: 76%

Looking within: Interoceptive sensibility in young adults with psychotic‐like experiences

Barbato

Arora

Hemeiri³

et al. 2021

Early Intervention Psych

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Aim: Interoception is the ability to sense internal bodily changes and research indicates that it may play a role in the development of mental illness. In recent years, preliminary evidence has shown that interoception is impaired in people with psychosis.Interoceptive sensibility, a meta-cognitive aspect of interoception, has never been studied across the psychosis continuum. The present study aimed at assessing interoceptive sensibility in youth with psychotic-like experiences. Method: We invited a sample of young adults (N = 609; age 19-21 years) to complete an online survey that included a measure of interoceptive sensibility (the Multidimensional Assessment of Interoceptive Awareness-2) and the Community Assessment of Psychotic Experiences-Positive Scale −15 (CAPE-P15). Using the recommended cutoff for the CAPE-P15, the overall sample was divided into two groups (high/low risk for psychosis).Results: Significant group differences were observed in several dimensions of interoceptive sensibility. A logistic regression analysis indicated that scores in the subscales of Not-Distracting, Not-Worrying, Attention-Regulation, Emotional Awareness, Body Listening, and Trusting significantly predicted increased risk for psychosis. Conclusion:Abnormal interoceptive sensibility may be a vulnerability marker for psychosis. These results, however, await further validation from additional comprehensive, longitudinal studies. Enhanced interoceptive sensibility has been reported following contemplative training, thus creating opportunities for future interventions to delay or prevent psychotic illness.

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confidence: 76%

Looking within: Interoceptive sensibility in young adults with psychotic‐like experiences

Barbato

Arora

Hemeiri³

et al. 2021

Early Intervention Psych

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“…Comparison of the different subtypes of telehealth intervention in relation to relapse demonstrated the greater effectiveness of online interventions, especially videoconferencing. Thus, although it is well known that psychiatric disorders such as schizophrenia and bipolar disorders are associated with impaired processing of emotional faces [25], in most of the studies reviewed, the telematic interventions in the field of mental health that proved to be the most effective in relapse prevention were carried out using applications that included face-to-face contact with a therapist. Improvements in treatment adherence, social functioning, and quality of life have also been found through videoconferencing, even in some cases, similar to those observed in the face-to-face intervention [26].…”

Section: Discussionmentioning

confidence: 99%

Occupational Therapy in Mental Health via Telehealth during the COVID-19 Pandemic

Sánchez-Guarnido¹,

Domínguez-Macías

Garrido-Cervera

et al. 2021

IJERPH

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The COVID-19 pandemic has brought about changes in mental health occupational therapy. Research into these changes and the associated risks of relapse is insufficient. To explore the changes that have taken place in forms of occupational intervention (face-to-face and online) during the pandemic, and to analyze their association with subsequent relapses, a multicenter retrospective cohort study was carried out of 270 patients with mental disorder diagnoses under follow-up in day hospitals during 2020. Our results show that the frequency of face-to-face occupational therapy interventions decreased during lockdown and subsequently recovered. Interventions via telehealth increased during lockdown and have since been continued to a greater extent than before lockdown. Patients who received occupational intervention via telehealth relapsed less in the following six months (10.7% vs. 26.3%; χ2 = 10.372; p = 0.001), especially those who received intervention via videoconferencing (4.2% vs. 22%; χ2 = 5.718; p = 0.017). In conclusion, lockdown subsequent to the COVID-19 outbreak led to a reduction in face-to-face occupational therapy interventions, putting people with prior mental disorders at risk, while the implementation of telehealth tools helped reduce relapses.

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“…Some studies in youth reporting PLEs have found increased limbic responses to ambivalent faces 18 or to threatening faces 19 , while others have observed decreased responses to emotional faces in the prefrontal, parahippocampal, and striatal regions 20 . In addition to their association with local activity changes, PLEs were associated with decreased amygdala–prefrontal connectivity during negative emotion processing 21 .…”

Section: Introductionmentioning

confidence: 99%

Neural alterations of emotion processing in atypical trajectories of psychotic-like experiences

et al. 2022

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The aim of this study was to investigate the neural bases of facial emotion processing before the onset of clinical psychotic symptoms in youth belonging to well-defined developmental trajectories of psychotic-like experiences (PLEs). A unique sample of 86 youths was recruited from a population-based sample of over 3800 adolescents who had been followed from 13 to 17 years of age. Three groups were identified based on validated developmental trajectories: a control trajectory with low and decreasing PLEs, and two atypical trajectories with moderate to elevated baseline PLEs that subsequently decreased or increased. All had functional magnetic resonance imaging data collected during a facial emotion processing task. Functional activation and connectivity data were analyzed for different contrasts. The increasing PLE trajectory displayed more positive psychotic symptoms while the decreasing trajectory exhibited more negative symptoms relative to the control group. During face processing, both atypical trajectories displayed decreased activations of the right inferior frontal gyrus (IFG), while the increasing trajectory displayed a negative signal in the precentral gyrus. The increasing PLE trajectory also displayed impaired connectivity between the amygdala, ventromedial prefrontal cortex, and cerebellum, and between the IFG, precuneus, and temporal regions, while the decreasing trajectory exhibited reduced connectivity between the amygdala and visual regions during emotion processing. Both atypical PLE trajectories displayed alterations in brain regions involved in attention salience. While the increasing trajectory with more positive symptoms exhibited dysconnectivity in areas that influence emotion salience and face perception, the decreasing trajectory with more negative symptoms had impairments in visual information integration areas. These group-specific features might account for the differential symptom expression.

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Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

Cited by 7 publications

References 39 publications

Looking within: Interoceptive sensibility in young adults with psychotic‐like experiences

Looking within: Interoceptive sensibility in young adults with psychotic‐like experiences

Occupational Therapy in Mental Health via Telehealth during the COVID-19 Pandemic

Neural alterations of emotion processing in atypical trajectories of psychotic-like experiences

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