Examination of the exchange of deuterium from deuterium oxide in carbon tetrachloride solution with hydrogen in glass using infrared spectrometry

Hydrogen-tritium exchange between glass-fiber filters and tritiated water

“…The average value for TIME (hours) Figure 3. Exchange curves between GF/C filters preheated at 500 °C for 20 h and tritiated water at various temperatures: 1 the exchange points at 100 °C is 2.55 X 10"4 g of H/g of glass and there is no clear indication of any additional exchange in the period from 20 min to 7 h after the start of exchange (compare with Figure 1). This loss of hydrogens from the glass is due to removal of water by heating (6,7).…”

“…problem in analytical procedures. For example, work on the infrared spectra of solutions of D20 in CC14 was complicated by the presence of HOD bands due to hydrogen exchange between D20 and borosilicate glass present in the infrared cell (1). Our own measurements of hydrogen-tritium exchange between biological membranes and tritiated water involved filtration of exchanged samples onto Whatman GF/C glass fiber filters, thorough washing with very dry tetrahydrofuran to remove all water, and liquid scintillation counting of residual tritium exchanged into the membranes.…”

A Novel Radiotracer Method for the Precise Determination of Water Vapor Transmission Rate Characteristics of Packaging Systems

“…*2 similarly enhanced adsorption of deuterium ions, as compared with protons, onto glass surfaces in contact with solutions of D2O or H20 in CCll has been shown. 13 The ideal water vapor scavenger should bind water tightly, to minimize both equilibrium isotope effects and facile proton exchange a t hydroxyl-rich surfaces. This can be accomplished with anhydrous CaCl,, which incorporates adsorbed water into a crystalline lattice."…”

“…To select optimum containers for packaging oral solid drugs, either in unit-dosage or in bulk form, it is essential to determine the susceptibility of candidate containers to moisture permeation. 13 Before choosing packaging for products that are moisture sensitive, it is necessary to determine moisture transmission properties of the container as part of the development of a simulation model for shelf-life prediction.-Typically, moisture transmission properties of container systems are determined by storing packages containing desiccant at constant temperature and humidity, then measuring their weight gain after storage. 5.7 These gravimetric methods require the use of appropriate blanks, which contain no desiccant, in order to distinguish between moisture absorbed by the package and moisture transmission through the package.…”

Ion selective electrodes, potentiometry, and potentiometric titrations

“…Exchange rates and transient potential responses have been reported by Karlberg (543)(544)(545). Ion exchange has been followed by radioactivity (792), and deuteron-proton exchange (357). Transfers of ions to silica (954) and to porous glasses (438) have been characterized by electrical measurements.…”