Examination of the effect of combined use of Er:YAG laser irradiation and mechanical force loading on bone metabolism using primary human gingival fibroblasts

Tsuka, Yuji; Kunimatsu, Ryo; Gunji, Hidemi; Abe, Takaharu; Medina, Cynthia Concepcion; Hiraki, Tomoka; Nakatani, Ayaka; Sakata, Shuzo; Rikitake, Kodai; Aisyah, Purtranti Nurul; Hirose, Norikazu; Yanosita, Makoto; Tanimoto, Kotaro

doi:10.1007/s10103-020-03079-y

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…PBM has been used extensively in medicine to treat pathological tissues characterized by some degree of alteration, such as scarring or inflammation [ 22 , 23 , 24 ]. The use of the laser shows several biomodulatory effects, including increased tissue repair, local circulation, and collagen synthesis [ 25 , 26 , 27 ]. Additional benefits of PBM use include the modulation of pro-inflammatory cytokines, such as TNF-α, IL1β , and IL6 [ 21 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model

Rosa

Peçanha

Carvalho

et al. 2023

IJMS

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Although the exact mechanism of the pathogenesis of coronavirus SARS-CoV-2 (COVID-19) is not fully understood, oxidative stress and the release of pro-inflammatory cytokines have been highlighted as playing a vital role in the pathogenesis of the disease. In this sense, alternative treatments are needed to reduce the level of inflammation caused by COVID-19. Therefore, this study aimed to investigate the potential effect of red photobiomodulation (PBM) as an attractive therapy to downregulate the cytokine storm caused by COVID-19 in a zebrafish model. RT-qPCR analyses and protein–protein interaction prediction among SARS-CoV-2 and Danio rerio proteins showed that recombinant Spike protein (rSpike) was responsible for generating systemic inflammatory processes with significantly increased levels of pro-inflammatory (il1b, il6, tnfa, and nfkbiab), oxidative stress (romo1) and energy metabolism (slc2a1a and coa1) mRNA markers, with a pattern similar to those observed in COVID-19 cases in humans. On the other hand, PBM treatment was able to decrease the mRNA levels of these pro-inflammatory and oxidative stress markers compared with rSpike in various tissues, promoting an anti-inflammatory response. Conversely, PBM promotes cellular and tissue repair of injured tissues and significantly increases the survival rate of rSpike-inoculated individuals. Additionally, metabolomics analysis showed that the most-impacted metabolic pathways between PBM and the rSpike treated groups were related to steroid metabolism, immune system, and lipid metabolism. Together, our findings suggest that the inflammatory process is an incisive feature of COVID-19 and red PBM can be used as a novel therapeutic agent for COVID-19 by regulating the inflammatory response. Nevertheless, the need for more clinical trials remains, and there is a significant gap to overcome before clinical trials can commence.

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Section: Introductionmentioning

confidence: 99%

Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model

Rosa

Peçanha

Carvalho

et al. 2023

IJMS

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“…PBM has been used extensively in medicine to treat pathological tissues characterized by some degree of alteration, such as scarring or in ammation 23,22,24,25 . Laser shows several biomodulatory effects, including increased tissue repair, local circulation, and collagen synthesis 26,27,28 . Additional bene ts of PBM use include the modulation of pro-in ammatory cytokines, such as TNF-α, IL1β, and IL6 29,30,22,31 .…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation reduces the cytokine storm syndrome associated with Covid-19 in the zebrafish model

Charlie-Silva

Barbosa

Pontes³

et al. 2022

Preprint

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This work presents the first study showing how photobiomodulation (PBM) significantly increases cellular and tissue repair and elucidating the role of PBM with low-level laser as a possible new therapy in pathologies in COVID-19-associated cytokine storm syndrome from a zebrafish model. Our results demonstrate new strategies for treating SARS-COV-2 using PBM to modulate the expression of the genes and metabolites involved in inflammatory processes. These metabolic alterations show that the r-Spike led to disturbance in the energetic and inflammatory system, corroborating with the severe clinical conditions of human patients. Furthermore, PBM decreased the gene expression levels of pro-inflammatory cytokines such as il1b, il6, tnfa, and nfkbiab, and of factors involved in oxidative stress (romo1) and energy metabolism (slc2a1a, coa1), in various tissues, promoting an anti-inflammatory response. In summary, our study suggests that PBM may have a positive role in treating cytokine storm syndrome associated with COVID-19. PBM can significantly regulate the inflammatory response promoting cellular and tissue repair of injured tissues. This work suggests that PBM may have a positive role in treating COVID-19-associated cytokine storm syndrome. Nevertheless, the need for more clinical trials remains, and there is a significant gap to overcome before clinical trials.

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The role of photobiomodulation in accelerating bone repair

Lu,

Peng,

Liu

et al. 2024

Progress in Biophysics and Molecular Biology

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Examination of the effect of combined use of Er:YAG laser irradiation and mechanical force loading on bone metabolism using primary human gingival fibroblasts

Cited by 6 publications

References 29 publications

Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model

Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model

Photobiomodulation reduces the cytokine storm syndrome associated with Covid-19 in the zebrafish model

The role of photobiomodulation in accelerating bone repair

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