Examination of <sup>11</sup>C-Methionine Metabolism by the Standardized Uptake Value in the Normal Brain of Children

Nagata, Takashi; Tsuyuguchi, Naohiro; Uda, Takehiro; Terakawa, Yuzo; Takami, Toshihiro; Ohata, Kenji

doi:10.2967/jnumed.110.082875

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…The highest uptake was found in the cerebellum and occipital cortex, with less in white matter. The study of Nagata also showed high uptake in the cerebellum of normal children and increasing SUV in the frontal lobes and cerebellum with age (27). …”

Section: Discussionmentioning

confidence: 93%

Evaluation of the Biodistribution of ¹¹C-Methionine in Children and Young Adults

et al. 2013

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The purpose of this study was to evaluate the biodistribution of carbon-11–labeled methionine in non–tumor-involved organs in pediatric patients studied for malignant diseases. Methods Ninety-three children and young adults with known or suspected malignancies underwent [11C]methionine positron emission tomography (PET) and computed tomography (CT) scans. Imaging began 5–15 min after injection of 740 MBq (20 mCi) per 1.7 m2 of body surface area. Images were acquired from the top of the head through the mid-thighs. Standardized uptake values were determined using regions of interest drawn on the CT and transferred to the corresponding transverse PET slice. Results The highest concentrations of [11C]methionine were found in the pancreas and liver. Less intense uptake was seen in other regions, such as salivary glands, tonsils, and bone marrow. There was very little uptake in lungs, fat (including brown adipose tissue), and muscle. Uptake in bone marrow, parotid glands, and tonsils was slightly but statistically significantly higher in males than females. Testicular, bone marrow, and left ventricular uptake increased with age. There was little variability statistically between comparisons of uptake change and groupings of age, race, sex, and patients studied at the time of diagnosis versus previously treated patients. Conclusion High uptake of [11C]methionine is reliably found in the pancreas and liver, consistent with the anabolic functions of these organs. Low uptake in the brain, neck, chest, pelvis, and extremities will facilitate tumor localization in those areas. However, intense uptake in the upper abdomen may limit the diagnostic utility of [11C]methionine in that area.

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Section: Discussionmentioning

confidence: 93%

Evaluation of the Biodistribution of ¹¹C-Methionine in Children and Young Adults

et al. 2013

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“…Magnetic resonance imaging (MRI) should precede 11 C-Met PET to check the morphological anatomy of the central nervous system (CNS). The effect of aging on physiological uptake in the brain is limited, although SUV in the normal brains of children is slightly different from that in the normal brains of adults ( 4 ). Whether or not the patients should be in the fasting state before 11 C-Met PET is also controversial.…”

Section: Physiological Uptake and Normal Variantsmentioning

confidence: 96%

Imaging Spectrum and Pitfalls of ¹¹C-Methionine Positron Emission Tomography in a Series of Patients with Intracranial Lesions

Ito

Kubota

2016

Korean J Radiol

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11C-methionine (Met) positron emission tomography (PET) is one of the most commonly used PET tracers for evaluating brain tumors. However, few reports have described tips and pitfalls of 11C-Met PET for general practitioners. Physiological 11C-Met uptake, anatomical variations, vascular disorders, non-tumorous lesions such as inflammation or dysplasia, benign brain tumors and patient condition during 11C-Met PET examination can potentially affect the image interpretation and cause false positives and negatives. These pitfalls in the interpretation of 11C-Met PET images are important for not only nuclear medicine physicians but also general radiologists. Familiarity with the spectrum and pitfalls of 11C-Met images could help prevent unfavorable clinical results caused by misdiagnoses.

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“…Moreover, methionine metabolism may vary with growth stage of life-cycle. Nagata et al [ 11 ] reported that the uptake of methionine in the brain of children gradually increased with age. In rat, activity of liver γ-cystathionase, a key enzyme for the transsulfuration of methionine, was lower in newborns than in adults [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship between dietary methionine and growth, digestion, absorption, and antioxidant status in intestinal and hepatopancreatic tissues of sub-adult grass carp (Ctenopharyngodon idella)

Tang

Jiang

et al. 2017

J Animal Sci Biotechnol

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BackgroundMethionine is an essential amino acid for fish. The present study was conducted to investigate the effects of dietary methionine on growth performance, digestive and absorptive ability, as well as antioxidant capacity in the intestine and hepatopancreas of sub-adult grass carp (Ctenopharyngodon idella).ResultsDietary methionine deficiency significantly decreased percentage weight gain (PWG), feed intake, feed efficiency and protein efficiency ratio, as well as activities of hepatopancreatic glutamate-oxaloacetate transaminase and muscle glutamate-pyruvate transaminase in sub-adult grass carp (P < 0.05). Furthermore, methionine deficiency significantly reduced activities of trypsin, lipase and amylase in the intestine, Na+/K+-ATPase, alkaline phosphatase and γ-glutamyl transpeptidase in three intestinal segments, and creatine kinase (CK) in the proximal intestine (P < 0.05). However, an unexplained and significant increase in CK activity in the mid intestine was associated with dietary methionine deficiency. Malondialdehyde and protein carbonyl contents in the intestine and hepatopancreas were significantly increased by methionine deficiency (P < 0.05), whereas anti-hydroxyl radical capacity in the hepatopancreas and intestine, and anti-superoxide anion capacity in the intestine, were significantly decreased by methionine deficiency (P < 0.05). Moreover, methionine deficiency significantly decreased superoxide dismutase and glutathione reductase activities, glutathione contents in the hepatopancreas and intestine, as well as glutathione peroxidase activity in the intestine (P < 0.05), whereas it significantly increased activities of catalase in the hepatopancreas and glutathione-S-transferase in the hepatopancreas and intestine (P < 0.05).ConclusionsThe present results demonstrated that dietary methionine deficiency induced poor growth, and decreased digestive and absorptive function and antioxidant capacity in the hepatopancreas and intestine of sub-adult grass carp. Methionine requirements for sub-adult grass carp (450-1, 170 g) based on PWG, intestinal trypsin, and hepatopancreatic anti-hydroxyl radical activities were estimated to be 6.12 g/kg diet (21.80 g/kg protein), 6.99 g/kg diet (24.90 g/kg protein) and 5.42 g/kg diet (19.31 g/kg protein), respectively, in the presence of 1.50 g cysteine/kg (5.35 g/kg protein).

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Examination of ¹¹C-Methionine Metabolism by the Standardized Uptake Value in the Normal Brain of Children

Cited by 11 publications

References 14 publications

Evaluation of the Biodistribution of ¹¹C-Methionine in Children and Young Adults

Evaluation of the Biodistribution of ¹¹C-Methionine in Children and Young Adults

Imaging Spectrum and Pitfalls of ¹¹C-Methionine Positron Emission Tomography in a Series of Patients with Intracranial Lesions

The relationship between dietary methionine and growth, digestion, absorption, and antioxidant status in intestinal and hepatopancreatic tissues of sub-adult grass carp (Ctenopharyngodon idella)

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Examination of 11C-Methionine Metabolism by the Standardized Uptake Value in the Normal Brain of Children

Cited by 11 publications

References 14 publications

Evaluation of the Biodistribution of 11C-Methionine in Children and Young Adults

Evaluation of the Biodistribution of 11C-Methionine in Children and Young Adults

Imaging Spectrum and Pitfalls of 11C-Methionine Positron Emission Tomography in a Series of Patients with Intracranial Lesions

The relationship between dietary methionine and growth, digestion, absorption, and antioxidant status in intestinal and hepatopancreatic tissues of sub-adult grass carp (Ctenopharyngodon idella)

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Product

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Examination of ¹¹C-Methionine Metabolism by the Standardized Uptake Value in the Normal Brain of Children

Evaluation of the Biodistribution of ¹¹C-Methionine in Children and Young Adults

Evaluation of the Biodistribution of ¹¹C-Methionine in Children and Young Adults

Imaging Spectrum and Pitfalls of ¹¹C-Methionine Positron Emission Tomography in a Series of Patients with Intracranial Lesions