1973
DOI: 10.1002/jps.2600620720
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Examination of Quinidine and Quinine and Their Pharmaceutical Preparations

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Cited by 40 publications
(8 citation statements)
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“…(5) mp 169 and 174'1; Rf 0.1 (chloroformethyl acetate, 2:l). Pure I1 was obtained by a repetition of the chromatographic procedure.…”
Section: I1mentioning
confidence: 99%
See 1 more Smart Citation
“…(5) mp 169 and 174'1; Rf 0.1 (chloroformethyl acetate, 2:l). Pure I1 was obtained by a repetition of the chromatographic procedure.…”
Section: I1mentioning
confidence: 99%
“…Therefore, it is not surprising that different investigators have reported varying data concerning the chemical shift of this OH proton (5). Therefore, it is not surprising that different investigators have reported varying data concerning the chemical shift of this OH proton (5).…”
Section: I1mentioning
confidence: 99%
“…Dihydroquinidine (DQ) is present as an impurity in variable amounts in quinidine preparations (Huynh-Ngoc and Sirois, 1974;Smith et al, 1973). The fact that it is structurally related to quinidine, led in the past to its being considered as one of the many quinidine salts employed as antiarrhythmic agents; however experimental and clinical studies (Hailey et 1945;Ueda and Makoid, 1979;Ueda et al, 1976;Weisman, 1942) have shown that the kinetics and bioavailability of DQ differ from those of quinidine; some other observations (Balazs et al, 1978;Dietman et al, 1977;Hollander and Besch, 1969) suggest that DQ has a different electrophysiologic action and that in some experimental settings DQ may be even more effective than quinidine (Alexander et Unlike quinidine, which is still widely used worldwide, purified DQ is commercially available in only a few countries.…”
Section: Introductionmentioning
confidence: 99%
“…Numerous chromatographic procedures have been developed for the determination of quinidine (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Several of them (7-10) are specific but time-consuming TLC procedures which we did not consider suitable for routine clinical monitoring.…”
mentioning
confidence: 99%
“…Several of them (7-10) are specific but time-consuming TLC procedures which we did not consider suitable for routine clinical monitoring. Some of them (11,12) have been applied only to pharmaceutical preparations. Several others (13)(14)(15) did not separate quinidine from dihydroquinidine.…”
mentioning
confidence: 99%