Examination of near-wall hemodynamic parameters in the renal bridging stent of various stent graft configurations for repairing visceral branched aortic aneurysms

Suess, Taylor N.; Anderson, Joseph; Danielson, Laura S.; Pohlson, Katie; Remund, Tyler; Blears, Elizabeth; Gent, Stephen P.; Kelly, Patrick

doi:10.1016/j.jvs.2015.04.421

Cited by 39 publications

(51 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TAWSS sites where the values are ≥10 Pa are shown in red colour. These sites are of clinical relevance as high values of TAWSS (≥10 Pa) can lead to the damage of endothelial cells (Suess et al 2016). Hence, in Fig.…”

Section: Tawss Distributions In Stenosed Arteriesmentioning

confidence: 96%

See 1 more Smart Citation

Effect of Stenosis Severity on Wall Shear Stress Based Hemodynamic Descriptors using Multiphase Mixture Theory

Buradi

Mahalingam

2018

JAFM

View full text Add to dashboard Cite

A variety of wall shear stress (WSS) based hemodynamic descriptors have been defined over the years to study hemodynamic flow instabilities as potential indicators or prognosticators of endothelial wall dysfunction. Generally, these hemodynamic indicators have been calculated numerically using 'single phase' approach. In single phase models, the flow-dependent cell interactions and their transport are usually neglected by treating blood as a single phase non-Newtonian fluid. In the present investigation, a multiphase mixture-theory model is used to define the motion of red blood cells (RBCs) in blood plasma and interactions between these two-components. The multiphase mixture theory model exhibited good agreement with the experimental results and performed better than non-Newtonian single phase model. The mixture-theory model is then applied to simulate pulsatile blood flow through four idealized coronary artery models having different degrees of stenosis (DOS) severities viz., 30, 50, 70 and 85% diameter reduction stenosis. The maximum WSS is seen at the stenosis throat in all the cases and maximum oscillatory shear index (OSI) is seen in downstream region of the stenosis. Our findings suggest that for degree of coronary stenosis more than 50%, a more disturbed fluid dynamics is observed downstream of stenosis. This could lead to further progression of stenosis and may promote a higher risk of atherogenesis and plaque buildup in the flow-disturbed area. The potential atherosclerotic lesion sites were identified based on clinically relevant values of WSS, timeaveraged WSS gradient (TAWSSG), time-averaged WSS (TAWSS), and OSI. Finally, the change in potential atherosclerotic lesion sites with respect to DOS has been quantified.

show abstract

Section: Tawss Distributions In Stenosed Arteriesmentioning

confidence: 96%

“…The value of TAWSS < 0.4 Pa endorses an atherogenic endothelial phenotype, whereas the values with high TAWSS (15-45 Pa) are known to thrombogenic (Malek et al 1999). The high values of TAWSS can lead to damage of endothelial cells (Suess et al 2016).…”

Section: Time-averaged Wall Shear Stressmentioning

confidence: 99%

Effect of Stenosis Severity on Wall Shear Stress Based Hemodynamic Descriptors using Multiphase Mixture Theory

Buradi

Mahalingam

2018

JAFM

View full text Add to dashboard Cite

show abstract

“…In this study, for simplicity, blood will be considered as Newtonian fluid with density of 1050 kg/m 3 and dynamic viscosity of 0.0035 Pa.s (Javadzadegan et al 2014;Ou et al 2017;Suess et al, 2016). Moreover, Suess et al (2016) claimed that the effect of non-Newtonian characteristic is influential only when the diameter of the vessel is less than 1 mm.…”

Section: Fluid Formulationsmentioning

confidence: 99%

Stent Porosity Efficiency in Treating Wide-Neck Saccular Renal Artery Aneurysm

Bakar¹,

Abas²,

Razak³

2020

JAFM

View full text Add to dashboard Cite

Renal arteries are the arteries that supply blood to the kidneys. Renal arteries are the arteries that supply blood to the kidneys. Renal artery aneurysm (RAA) is the second most common visceral aneurysm to occur, which accounts for 22% of the visceral aneurysm. In general population, RAA rate of occurrence was only 0.1%. However, due to the extensive used of angiography technique, RAA has been discovered more frequently. Some claimed that the previous rate of incidence should be higher now because of the capability of angiography. The rupture of this aneurysm could result in haemorrhage, kidney lost and mortality. The size of the renal artery which is different compared to other types of arteries such as the abdominal aorta could produce different flow condition when the artery is inflicted with RAA condition. Thus, a thorough analysis is desired as RAA studies are very limited compared to other aneurysm conditions. In this study, the efficiency of the stent porosity was investigated in treating the RAA. Fluid-structure interaction (FSI) simulations and particle image velocimetry (PIV) experiments were the approaches taken to investigate the flow patterns of the blood when the stent of different porosities was placed in the aneurysm entrance. The effect of wall shear stress (WSS), the deformation of the artery and von Mises stress were also observed in determining the possibility of aneurysm rupture. The study found that the placement of stent of different porosities succeeds in providing an obstruction to the blood from circulating inside the aneurysm sac. This in turns reduced the WSS experienced by the aneurysm sac up a significant value of 96%. This reduction is crucial in order to prevent the aneurysm from rupture. Moreover, the placement of the stent provided support to the renal artery and preventing it from experiencing buckling failure. The maximum deformation of the artery reduced by 42% with stent was placed in the renal artery. In fact, the von Mises stress decreased below the threshold limit of 0.5 MPa with the presence of the stent. In addition, the study found that the stent of porosity 80% has a similar impact to the stent of lower porosity in the case of RAA at main renal artery.

show abstract

“…The blood has shear thinning like behavior where it becomes less viscous with an increase in stresses applied to it. However, Suess et al (2016) explained that the effect of non-Newtonian characteristic of the blood is only applicable in vessel with diameter of less than 1 mm. Therefore, for this study, the authors simply considered the blood as a Newtonian fluid with density of 1050 kg/m3 and dynamic viscosity of 0.0035 Pa.s.…”

Section: Continuity Equationmentioning

confidence: 99%

“…The size of the aneurysm is 28 × 24 mm. The diameter of renal artery is 6 mm (Bracale et al, 2017;Suess et al, 2016), the thickness is 0.5 mm (Leertouwer et al, 1999) with the length of 65 mm. in this study, the renal artery material properties is taken as isotropic, linear elastic solid Corey J.…”

Section: Renal Artery Aneurysmmentioning

confidence: 99%

Effectiveness of Stent in the Treatment of Renal Artery Aneurysm using FSI Simulation

Bakar¹,

Abas²,

Razak³

2019

JAFM

View full text Add to dashboard Cite

Renal artery aneurysm (RAA) is a condition that affects approximately 0.1% of the general population. The rate of incidence is minimal compared to other type of aneurysm but a high number of ruptures have been reported in pregnancy, especially at the third trimester. The concerning issue is that the maternal mortality rate stretches up to 50% and the fetal mortality rate approaching 85% with a universal loss of the affected kidney. This study aimed at investigating the effectiveness of stent in treatment of RAA using the fluid-structure interaction (FSI) approach. The flow pattern, wall shear stress (WSS), deformation and von Mises stress experienced are compared between RAA model without stent and with Abbott RX Herculink stent. A simple PIV experiment, observing the flow profile was conducted as a validation steps in ensuring the simulation results are reliable and accurate. The findings show that the simulation and PIV data are in good agreement in terms of the flow profile. The presence of stent managed to reduce the blood flow maximum velocity down to 46% and minimized the circulation of blood in the aneurysm dome. As for the WSS, the used of stent succeeded in decreasing the WSS experienced by the wall of aneurysm by 71% and below the baseline level of WSS that could induced rupture. The deformation of RAA and maximum von Mises stress reduced by 58% and 73% respectively when stent is used. In addition, the maximum von Mises stress after the stent placement is lower than the threshold value for the ultimate tensile strength of the tissue. This study concluded that the stent placement is effective in reducing the risk of aneurysm rupture in renal artery it can be one of the baseline for the further study regarding the RAA.

show abstract

Examination of near-wall hemodynamic parameters in the renal bridging stent of various stent graft configurations for repairing visceral branched aortic aneurysms

Cited by 39 publications

References 20 publications

Effect of Stenosis Severity on Wall Shear Stress Based Hemodynamic Descriptors using Multiphase Mixture Theory

Effect of Stenosis Severity on Wall Shear Stress Based Hemodynamic Descriptors using Multiphase Mixture Theory

Stent Porosity Efficiency in Treating Wide-Neck Saccular Renal Artery Aneurysm

Effectiveness of Stent in the Treatment of Renal Artery Aneurysm using FSI Simulation

Contact Info

Product

Resources

About