Examination of mitral regurgitation with a goat heart model for the development of intelligent artificial papillary muscle

Shiraishi, Yasuyuki; Yambe, Tomoyuki; Yoshizawa, Makoto; Hashimoto, Hisashi; Yamada, Akihiro; Miura, Hiroko; Hashem, Mohamed O.; Kitano, Tomoya; Shiga, Takuya; Homma, Dai

doi:10.1109/embc.2012.6347519

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The similarity of organ size between goats and humans makes these animals widely used. They are used in human medicine in research such as cardiac, orthopedic, model for infectious diseases or many others (Shiraishi et al 2012;Chen et al 2015;Zhang et al 2015;Lukovsky-Akhsanov et al 2016;Du et al 2018;Vandersteene et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Topography of coronary arteries and their ramifications in the goat

et al. 2019

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The aim of this study was to investigate the morphology of the coronary arteries of the goat's heart. The study was carried out on 36 hearts of adult females dairy goats, belonging to two breeds, aged 7-12 years, with an average body weight of 37 kg. A distinct view of coronary arteries and their branches was obtained by filling them with dyed synthetic latex (LBS 3060) or Batson's No. 17. In all studied goats the common trunk of the left coronary artery was divided into the interventricular paraconal branch and the circumflex branch. The branch of the interventricular septum originated in the interventricular paraconal branch. In 25 individuals (69%) the circumflex branch ended with small ramifications on the atrial surface of the heart. In 11 individuals (31%), the vessel extended in the subsinuosal interventricular groove into the subsinuosal interventricular branch. The right coronary artery was less developed than the left coronary artery. In 35 individuals (97%) the right coronary artery ended with small ramifications on the atrial surface of the heart. In one goat (3%) the vessel reached the subsinuosal interventricular groove and extended into the subsinuosal interventricular branch.

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Section: Introductionmentioning

confidence: 99%

Topography of coronary arteries and their ramifications in the goat

et al. 2019

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“…The dimensions of the goat heart are very similar to the heart of an adolescent human, which makes them a good model of heart failure by coronary artery ligation, just like in sheep [ 87 ]. Goats were also used to create models of persistent atrial fibrillation associated with chronic left atrial overload [ 88 , 89 ] and in transgenic animals [ 90 ], the development of intelligent artificial papillary muscles for surgical restoration in valvular disease [ 91 ] and for fetal heart surgery techniques [ 92 ]. When used in a left anterior descending coronary artery ligation model, gBM-MSCs in combination with a small intestinal submucosal film were able to prevent left ventricular chamber dilation, ensuring good cardiac function, collateral perfusion and myocardial contractile capacity [ 93 ].…”

Section: Small Ruminants As Animal Models and Regenerative Medicinmentioning

confidence: 99%

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Alvites

Branquinho

Sousa

et al. 2021

Biology

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Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions, larger than conventional laboratory animals, but very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with a focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

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“…The dimensions of the goat heart are identical to the heart of an adolescent human, which makes them a good model of heart failure by coronary artery ligation, just like sheep (81). Goats also allowed to create models of persistent atrial fibrillation associated with chronic left atrial overload (82,83) and in transgenic animals (84), the development of intelligent artificial papillary muscles for surgical restoration of valvular diseases (85) and fetal heart surgery techniques (86). When used in a left anterior descending coronary artery ligation model, gBM-MSCs in combination with a small intestinal submucosal film were able to prevent the left ventricular chamber dilation, ensuring good cardiac function, collateral perfusion and myocardial contractile capacity (87).…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

Alvites¹,

Branquinho²,

Sousa³

et al. 2021

Preprint

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Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

show abstract

Examination of mitral regurgitation with a goat heart model for the development of intelligent artificial papillary muscle

Cited by 4 publications

References 8 publications

Topography of coronary arteries and their ramifications in the goat

Topography of coronary arteries and their ramifications in the goat

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

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