Examination of Kidney Function

Schück, O

doi:10.1007/978-94-009-5660-5

Cited by 21 publications

(12 citation statements)

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“…Creatinine clearance measured without (CC) or with cimetidine (CCWC), which is almost the same as inuline clearance due to the blocking effect that cimetidine has on the proximal tubular secretion of creatinine, has proved to be significantly lower in the very old healthy people in comparison to that documented on the younger population [1,2] : CC: 43 mL/min per 1.73 m 2 (aged) vs 144 mL/min per 1.73 m 2 (young), (P = 0.01); CCWC: 50 mL/min per 1.73 m 2 (aged) vs 112 mL/min per 1.73 m 2 (young), (P = 0.01). The observed difference in the creatinine filtration between the studied age groups could be justified as a consequence of the decrease in the number of glomerular units secondary to their obliteration due to the EDITORIAL glomeruloscrerosis which accompanies ageing [3][4][5] .…”

Section: Creatinine Handlingmentioning

confidence: 92%

“…This phenomenon could explain the lower sodium reabsorption at the TALH in very old healthy people [14,[21][22][23] . Besides, it has been documented that free water clearance (a marker of TALH function) is considerably lower in the very old in comparison with the young: 6 mL/min per 1.73 m 2 vs 15 mL/min per 1.73 m 2 , respectively (P = 0.01) [14] .…”

Section: Water and Sodium Handlingmentioning

confidence: 99%

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Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old

Musso

Gregori²,

Jáuregui³

et al. 2012

WJN

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Renal physiology in the healthy oldest old has the following characteristics, in comparison with the renal physiology in the young: a reduced creatinine clearance, tubular pattern of creatinine back-filtration, preserved proximal tubule sodium reabsorption and uric acid secretion, reduced sodium reabsorption in the thick ascending loop of Henle, reduced free water clearance, increased urea excretion, presence of medulla hypotonicity, reduced urinary dilution and concentration capabilities, and finally a reduced collecting tubules response to furosemide which expresses a reduced potassium excretion in this segment due to a sort of aldosterone resistance. All physiological changes of the aged kidney are the same in both genders.

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Section: Creatinine Handlingmentioning

confidence: 92%

Section: Water and Sodium Handlingmentioning

confidence: 99%

Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old

Musso

Gregori²,

Jáuregui³

et al. 2012

WJN

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“…Th e antihypertensive therapy was not changed (ACEI + ARB), but its dose was modifi ed when monitoring blood pressure with goal levels of 125/80 mmHg. Proteinuria was in the range 2.3-3.5 g per 24 h. Inulin clearance and corrected creatinine clearance were determined for the estimation of renal function in the clearance laboratory of the Department of Nephrology [21].…”

Section: Methodsmentioning

confidence: 99%

Increased proinflammatory cytokine production in adipose tissue of obese patients with chronic kidney disease

Teplan

Vyhnánek

Gürlich

et al. 2010

Wien Klin Wochenschr

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“…During the 8-h period, the creatinine clearance (C Cr ), diuresis, or sodium and solute excretion was a total of several urine samples, and in each urine sample at the time interval studied there was different concentration of the studied substances. The following formula [18] was used for calculation of C Cr , sodium excretion (U Na V), solute excretion (U Osm V), and volume (V) (for instance, U Na V) during each 8-h period: U Na V= where the index 1, 2, 3, 4 in U Na and V designates the sample number and t, the time. Similar formulae, but with replacement of U Na V with U Osm V, U Cr V or V, were used to calculate the glomerular filtration rate and excretion of the solute or urine for each 8-h interval.…”

Section: Renal Function In Nocturnal Enuresismentioning

confidence: 99%

Nocturnal enuresis: correction of renal function by desmopressin and diclofenac

Natochin¹,

2000

Pediatric Nephrology

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Sixty-two children with nocturnal enuresis (43 boys, 19 girls aged 6-15 years) were treated with either desmopressin (Adiuretin-SD) (n = 32) or sodium diclofenac (n = 30). Desmopressin was effective in 85% of children and diclofenac in 33%. In children with primary nocturnal enuresis, the glomerular filtration rate was normal, whereas diuresis and solute excretion during the night were increased. Compared with healthy children, the nightly excretion of sodium was elevated by 43.7% and magnesium by 58.4%. A high correlation was found between the free water reabsorption and solute clearance (P < 0.001) in children with nocturnal enuresis. Changes in kidney function in nocturnal enuresis appear to be due to a decrease in the water and ion reabsorption in the thick ascending limb of Henle's loop because of a changed regulation of ion transport in this part of the nephron. Administration of desmopressin or a decrease in prostaglandin production after diclofenac administration restores the ion and water transport in the kidney, which results in the disappearance of nocturnal enuresis. The results indicate a role of changes in regulation of ion transport in renal tubules in the pathogenesis of one of the forms of primary nocturnal enuresis.

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Examination of Kidney Function

Cited by 21 publications

References 0 publications

Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old

Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old

Increased proinflammatory cytokine production in adipose tissue of obese patients with chronic kidney disease

Nocturnal enuresis: correction of renal function by desmopressin and diclofenac

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