Examination of HLA-DR4 as a severity marker for rheumatoid arthritis in Greek patients.

Boki, Kyriaki; Drosos, A A; Tzioufas, A G; Lanchbury, Jerry S.; Panayi, G. S.; Moutsopoulos, H M

doi:10.1136/ard.52.7.517

Cited by 43 publications

(27 citation statements)

References 27 publications

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“…Studies have shown that HLA B49 and DR4 can be found more frequently in patients with Graves' disease and that HLA DR4 is associated with immunoglobulin A nephropathy and rheumatoid arthritis. [17][18][19][20] Association with MPGN type I was not previously reported. In the study by Welch et al, 21 patients with MPGN types I and III and the extended haplotype HLA B8, DR3, SC01, GL02 progress more rapidly to end-stage renal disease.…”

Section: Discussionmentioning

confidence: 74%

Recurrent Membranoproliferative Glomerulonephritis Type I After Kidney Transplantation

et al. 2015

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Section: Discussionmentioning

confidence: 74%

Recurrent Membranoproliferative Glomerulonephritis Type I After Kidney Transplantation

et al. 2015

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“…28 The frequency of the shared epitope seems to be higher in patients with chronic rheumatoid arthritis in northern Europe and Caucasians in North America than in Mediterranean countries. [29][30][31] However, the situation in the control populations is often unclear. To analyse such effects better, we compared the genetic contribution to susceptibility and severity in Syria and France and compared this effect between the countries.…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope

Kazkaz

Marotte

Hamwi

et al. 2006

Annals of the Rheumatic Diseases

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Objective: To investigate whether ethnic differences exist in the effect of the shared epitope and selected cytokine gene polymorphisms on the susceptibility and severity of rheumatoid arthritis in Syria (Damascus) and France (Rhône-Alpes area). Methods: 156 patients with rheumatoid arthritis and 120 healthy controls from Syria were compared with 512 patients with rheumatoid arthritis and 471 healthy controls from France. Shared epitope status, cytokine gene polymorphisms interleukin (IL)-1B +3954, IL-1RN +2018 and tumour necrosis factor a promoter (2238 and 2308) were analysed by enzyme-linked oligosorbent assay. Joint destruction was defined by a right wrist Larsen score >2. Odds ratios (ORs) were calculated. Results: In both countries, a dose effect was observed between the shared epitope copy number and rheumatoid arthritis (Syria: OR 1 v 0 copies = 1.6, p = NS; OR 2 v 0 = 15.3, p,0.01; and France: OR 1 v 0 = 2.3, p,0.001; OR 2 v 0 = 7.2, p,0.001). A dose effect was also observed between the shared epitope copy number and joint destruction in Syria (OR 1 v 0 = 2.2, p = NS; OR 2 v 0 = 9.9, p,0.01) and France (OR 1 v 0 = 1.8, p,0.01; OR 2 v 0 = 4.8, p = 0.001). The dose effect of the shared epitope was greater in Syria than in France. Only the 2238 tumour necrosis factor a polymorphism was associated with joint destruction in the Syrian population (p,0.05). However, after adjustment for age, sex, disease duration and rheumatoid factor for severity, this association disappeared. Conclusion: The frequency of the shared epitope was increased in the French population with rheumatoid arthritis and in controls, but the association between the shared epitope and joint destruction was more pronounced in the Syrian population, with an OR of almost 10 for the homozygotes.

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“…Differences in SE encoding alleles may be relevant as these are not equivalent in prognostic terms. Severe disease has been associated with SE9, a double SE allele,6 25 26 and with certain DR4 alleles or their combinations,7 25-28whereas DR1 may be associated with a milder disease course 2829 From the above mentioned data, it might be expected that RA should be mild in populations with a high prevalence of DR1 and a low prevalence of DR4 alleles, such as Italy, Spain, and Portugal, and more severe in Belgium and the Netherlands, where DR4 is most common.…”

Section: Discussionmentioning

confidence: 99%

Clinical and immunogenetic characteristics of European multicase rheumatoid arthritis families

Balsa

2001

Annals of the Rheumatic Diseases

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Objective-To describe the characteristics of a new set of European families with aVected sib pairs (ASP) collected by the European Consortium on Rheumatoid Arthritis Families (ECRAF) to replicate the results of our first genome scan. Potential gradients for disease severity in Europe and concordance within families were studied. Patients and methods-From 1996 to 1998 European white families with at least two aVected siblings were enrolled in the study. Demographic (sex, age at onset), clinical data (rheumatoid factor (RF), disease duration, erosive disease, extraarticular features (EF)), and HLA-DRB1 oligotyping were analysed. Results-565 patients with rheumatoid arthritis (RA), belonging to 271 families including 319 aVected sib pairs (ASP) were collected. Belgium, France, Italy, the Netherlands, Portugal, and Spain contributed 20, 96, 52, 24, 9, and 70 families, respectively. Sex (78% women), age at onset (mean 44 years), and RF positivity (79%) were similar among the countries. DiVerences were found in disease duration (11-18 years) and in the prevalence of erosive disease (70-93%), nodules (15-44%), subjective Sjögren's syndrome (5-38%), and EF (3-16%) (p<0.05 in all cases). A total of 22% RA sibs were shared epitope (SE) negative, whereas 47% and 30% carried one and two SE alleles respectively. Carriage of SE diVered widely among countries (p<0.0001): no SE alleles (6-36%), one allele (43-60%), and two alleles (20-39%). SE encoding alleles were mainly DRB1*04 in the Netherlands and Belgium, whereas SE carriage was less common and evenly distributed between DRB1*01, *04, and *10 in Mediterranean countries. No concordance within families was found either in age/calendar year of onset (intraclass correlation coefficient <0.50) or in clinical and radiological features ( <0.22). Conclusions-The diVerences in RA characteristics between European countries and within families underline the heterogeneity of the disease. No clear cut gradient of disease severity was seen in Europe.

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Examination of HLA-DR4 as a severity marker for rheumatoid arthritis in Greek patients.

Abstract: Objectives-Previous reports have shown that HLA

Cited by 43 publications

References 27 publications

Recurrent Membranoproliferative Glomerulonephritis Type I After Kidney Transplantation

Recurrent Membranoproliferative Glomerulonephritis Type I After Kidney Transplantation

Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope

Clinical and immunogenetic characteristics of European multicase rheumatoid arthritis families

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