Examination of cutaneous T‐cell lymphoma for human herpesviruses by using the polymerase chain reaction

Brice, Sylvia L.; Jester, Joy D.; Friednash, M; Golitz, Loren E.; Leahy, Maureen A.; Stockert, Stephen S.; Weston, William L.

doi:10.1111/j.1600-0560.1993.tb01266.x

Cited by 25 publications

(9 citation statements)

References 29 publications

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“…EBV-encoded small nonpolyadenylated RNAs (EBERs) were detected by in situ hybridization in mycosis fungoides (MF) 17 and CTCL. 18 On the other hand, PCR, revealed no EBV DNA in CTCL 19 and Angele et al 20 showed the absence of EBER in CTCL. EBER has not yet been functionally characterized.…”

mentioning

confidence: 99%

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

et al. 2001

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mentioning

confidence: 99%

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

et al. 2001

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“…More widely in lymphoproliferative skin disorders, the possible role of HHV‐6 has been investigated in three other studies. Two studies concerned cutaneous T‐cell lymphoma (CTCL): the first one showed only one HHV‐6 positive sample out of 30 lesional tissue samples coming from CTCL (35) and the second one only one out of 92 MF (13). Kempf et al.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the role of human herpes virus 6 and 8 in parapsoriasis

Quéreux¹,

André-Garnier²,

Knol³

et al. 2009

Experimental Dermatology

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This study does not confirm the suspected role of HHV-6 or -8 in parapsoriasis. HHV-8 has been the most studied virus in parapsoriasis and more widely in cutaneous lymphoproliferative diseases and our results are in agreement with most of the studies which found none or few HHV-8 in more advanced stages of cutaneous lymphoproliferative diseases. Concerning HHV-6, our study is the first one investigating the presence of this virus in lesional tissue samples of patients with parapsoriasis. In conclusion, parapsoriasis does not seem to be associated with either HHV-6 or HHV-8.

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“…failed to show EBV positivity by PCR in 30 MF/SS subjects. 17 Iwatsuki et al . found no EBV positivity by PCR and ISH in 19 MF/SS subjects.…”

Section: Discussionmentioning

confidence: 99%

Examination of mycosis fungoides for the presence of Epstein-Barr virus and human herpesvirus-6 by polymerase chain reaction

ERKEK¹

1998

Journal of the European Academy of Dermatology and Venereology

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Background The aetiology of cutaneous T-cell lymphoma (CTCL) remains unknown despite numerous investigations. In recent years, retroviruses and human herpesviruses have been implicated to play a causal part in CTCL.Objective The aim of this study was to elucidate the possible aetiopathogenetic role of human herpesviruses (HHV) in mycosis fungoides (MF). Methods Polymerase chain reaction was used to study formalin-fixed, paraffin-embedded lesional skin biopsies from 92 subjects with MF to evidence possible presence of Epstein-Barr virus (EBV) and HHV-6. Results Biopsy specimens from nine subjects (9.8%) evidenced EBV DNA, whereas all except one of the subjects (1.1%) lacked HHV-6 DNA. Conclusions Although these findings do not support a primary aetiological role for EBV and HHV-6 in classical CTCL, the possibility remains that both viruses, particularly EBV, may act as potential cofactors in the development of CTCL.

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Examination of cutaneous T‐cell lymphoma for human herpesviruses by using the polymerase chain reaction

Cited by 25 publications

References 29 publications

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

Evaluation of the role of human herpes virus 6 and 8 in parapsoriasis

Examination of mycosis fungoides for the presence of Epstein-Barr virus and human herpesvirus-6 by polymerase chain reaction

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