Examination of a biodegradable magnesium screw for the reconstruction of the anterior cruciate ligament: A pilot in vivo study in rabbits

Diekmann, Julia; Bauer, Sylvie; Weizbauer, Andreas; Willbold, Elmar; Windhagen, Henning; Helmecke, Patrick; Lucas, Arne; Reifenrath, Janin; Nolte, Ingo; Ezechieli, Marco

doi:10.1016/j.msec.2015.11.037

Cited by 67 publications

(103 citation statements)

References 44 publications

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“…For the examination of systemic toxic effects in particular, a time interval of at least approximately 1 year should be observed. As examples, 1 week, 4 to 8 weeks, and 48 weeks are possible choices of suitable time intervals for these evaluations …”

Section: In Vivo Testing Of Magnesium Alloysmentioning

confidence: 99%

“…48,49 Pure magnesium 45,50-52 and a variety of different alloys have already been tested in vivo. Major alloy components are calcium, 49,53 aluminum, 48,54 zinc, 55 lithium, 56 and rare earth elements or zirconium, 52,56,57 which are alloyed in amounts up to approximately 10%. During the degradation process, these alloying elements can form complexes in the direct implant environment or distribute systemically via the circulation.…”

Section: In Vivo Testing Of Magnesium Alloysmentioning

confidence: 99%

“…As examples, 1 week, 4 to 8 weeks, and 48 weeks are possible choices of suitable time intervals for these evaluations. 57 Histological analysis of hard tissues and implant-tissue interfaces In orthopedic and trauma surgery, artificial implants are central tools to permanently replace parts of the body which are lost, or have lost their function. Implants for this purpose are necessarily made of materials which are inert, highly biocompatible and able to maintain their function over as long a period as possible.…”

Section: In Vivo Testing Of Magnesium Alloysmentioning

confidence: 99%

“…5), measurements are often performed in the bony environment to evaluate the degradation rate and the corresponding bone degradation prior to explantation and, in these cases, it is not possible to first detach the corrosion layer. Some examinations are performed using hardware and software able to differentiate, for example, using synchrotron CT. 44 In other studies, the ability to differentiate between the corrosion layer and implant material has been limited, and the corrosion layer was, at least partially, included in the calculation of the corrosion rate, 57,105,106 which obviously decreased the calculated values of corrosion rates. The implant location and type of animal, which can range from mouse to sheep, are also important because the degradation rate of a device will depend on its environment.…”

Section: Analysis Of the Corrosion Ratementioning

confidence: 99%

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Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Willbold

Weizbauer

Loos³

et al. 2016

J Biomedical Materials Res

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The first degradable implant made of a magnesium alloy, a compression screw, was launched to the clinical market in March 2013. Many different complex considerations are required for the marketing authorization of degradable implant materials. This review gives an overview of existing and proposed standards for implant testing for marketing approval. Furthermore, different common in vitro and in vivo testing methods are discussed. In some cases, animal tests are inevitable to investigate the biological safety of a novel medical material. The choice of an appropriate animal model is as important as subsequent histological examination. Furthermore, this review focuses on the results of various mechanical tests to investigate the stability of implants for temporary use. All the above aspects are examined in the context of development and testing of magnesium-based biomaterials and their progress them from bench to bedside. A brief history of the first market launch of a magnesium-based degradable implant is given. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 329-347, 2017.

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Section: In Vivo Testing Of Magnesium Alloysmentioning

confidence: 99%

Section: In Vivo Testing Of Magnesium Alloysmentioning

confidence: 99%

Section: In Vivo Testing Of Magnesium Alloysmentioning

confidence: 99%

Section: Analysis Of the Corrosion Ratementioning

confidence: 99%

See 2 more Smart Citations

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Willbold

Weizbauer

Loos³

et al. 2016

J Biomedical Materials Res

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“…Optimally, secure graft fixation allows for an aggressive postoperative rehabilitation program and early return to athletic activity. Several different fixation devices are available for ACL construction, this implant has become the gold standard for graft fixation devices . The first interference screw, utilized in ACL graft fixation was a metallic device which obtained good results .…”

mentioning

confidence: 99%

Improvement of bone‐tendon fixation by porous titanium interference screw: A rabbit animal model

Tsai

Chen

Huang

et al. 2018

Journal Orthopaedic Research

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The interference screw is a widely used fixation device in the anterior cruciate ligament (ACL) reconstruction surgeries. Despite the generally satisfactory results, problems of using interference screws were reported. By using additive manufacturing (AM) technology, we developed an innovative titanium alloy (Ti Al V) interference screw with rough surface and inter-connected porous structure designs to improve the bone-tendon fixation. An innovative Ti Al V interference screws were manufactured by AM technology. In vitro mechanical tests were performed to validate its mechanical properties. Twenty-seven New Zealand white rabbits were randomly divided into control and AM screw groups for biomechanical analyses and histological analysis at 4, 8, and 12 weeks postoperatively; while micro-CT analysis was performed at 12 weeks postoperatively. The biomechanical tests showed that the ultimate failure load in the AM interference screw group was significantly higher than that in the control group at all tested periods. These results were also compatible with the findings of micro-CT and histological analyses. In micro-CT analysis, the bone-screw gap was larger in the control group; while for the additive manufactured screw, the screw and bone growth was in close contact. In histological study, the bone-screw gaps were wider in the control group and were almost invisible in the AM screw group. The innovative AM interference screws with surface roughness and inter-connected porous architectures demonstrated better bone-tendon-implant integration, and resulted in stronger biomechanical characteristics when compared to traditional screws. These advantages can be transferred to future interference screw designs to improve their clinical performance. The AM interference screw could improve graft fixation and eventually result in better biomechanical performance of the bone-tendon-screw construct. The innovative AM interference screws can be transferred to future interference screw designs to improve the performance of implants. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2633-2640, 2018.

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Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

et al. 2020

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Biodegradable Mg‐based metals may be promising orthopedic implants for treating challenging bone diseases, attributed to their desirable mechanical and osteopromotive properties. This Review summarizes the current status and future research trends for Mg‐based orthopedic implants. First, the properties between Mg‐based implants and traditional orthopedic implants are compared on the following aspects: in vitro and in vivo degradation mechanisms of Mg‐based implants, peri‐implant bone responses, the fate of the degradation products, and the cellular and molecular mechanisms underlying the beneficial effects of Mg ions on osteogenesis. Then, the preclinical studies conducted at the low weight bearing sites of animals are introduced. The innovative strategies (for example, via designing Mg‐containing hybrid systems) are discussed to address the limitations of Mg‐based metals prior to their clinical applications at weight‐bearing sites. Finally, the available clinical studies are summarized and the challenges and perspectives of Mg‐based orthopedic implants are discussed. Taken together, the progress made on the development of Mg‐based implants in basic, translational, and clinical research has laid down a foundation for developing a new era in the treatment of challenging and prevalent bone diseases.

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Examination of a biodegradable magnesium screw for the reconstruction of the anterior cruciate ligament: A pilot in vivo study in rabbits

Cited by 67 publications

References 44 publications

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Improvement of bone‐tendon fixation by porous titanium interference screw: A rabbit animal model

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

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