Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype

Benno, Robert H.; Smirnova, Yelena; Vera, Susy; Liggett, Amanda; Schanz, Norman

doi:10.1016/j.bbr.2008.09.041

Cited by 57 publications

(61 citation statements)

References 27 publications

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“…Indeed, we found more pronounced duration of USV calls in BTBR than C57BL animals in response to the foot-shock in spite of their low expression of behavioral freezing, pointing out that USVs are different from this behavioral parameter of fear response, supporting previous report on CaMKIV À/À mice (Ko et al, 2005). Moreover, in response to the fearful context, individually-trained BTBR mice gave USV calls of longer duration than the C57BL group, supporting their high stress responsiveness (Benno et al, 2009). Co-training of mice of both inbred strains with a BTBR partner as a "fear facilitator" that emitted more USVs during the training session significantly facilitated contextual fear memory that corresponds to behavioral freezing.…”

Section: Fear Conditioningsupporting

confidence: 80%

“…Indeed, a recent study found that diazepam, an anxiolytic compound, was able to normalize the social preference in BTBR mice . The exaggerated response to stress in BTBR mice was previously shown through increased levels of corticosterone in the blood compared to C57BL strain (Benno et al, 2009), so perhaps social learning might reduce the increased level of corticosterone and improve episodic memory, suggesting neuroendocrine mechanisms underlying the effects of social learning on emotional-cognitive processes.…”

Section: Spatial Object Recognitionmentioning

confidence: 94%

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Co-learning facilitates memory in mice: A new avenue in social neuroscience

Lipina

Roder

2013

Neuropharmacology

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Section: Fear Conditioningsupporting

confidence: 80%

Section: Spatial Object Recognitionmentioning

confidence: 94%

Co-learning facilitates memory in mice: A new avenue in social neuroscience

Lipina

Roder

2013

Neuropharmacology

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“…One potential confound to consider is the role anxiety may contribute to the social behavior deficits and perseverative behaviors in the BTBR mouse. To date, there are numerous conflicting reports using a range of behavioral assays stating both elevated anxiety-like responses (Benno et al, 2009; Pobbe et al, 2011) and low stress responses (Silverman et al, 2010) as well as no observable difference in anxiety-like behaviors compared to the C57BL/6J mouse (Karvat and Kimchi, 2012; McFarlane et al, 2008; Moy et al, 2007). …”

Section: Behavioral Phenotypementioning

confidence: 99%

Inflammatory profiles in the BTBR mouse: How relevant are they to autism spectrum disorders?

Careaga

Schwartzer

Ashwood

2015

Brain, Behavior, and Immunity

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Autism spectrum disorders (ASD) are a group of disorders characterized by core behavioral features including stereotyped interests, repetitive behaviors and impairments in communication and social interaction. In addition, widespread changes in the immune systems of individuals with ASD have been identified, in particular increased evidence of inflammation in the periphery and central nervous system. While the etiology of these disorders remains unclear, it appears that multiple gene and environmental factors are involved. The need for animal models paralleling the behavioral and immunological features of ASD is paramount to better understand the link between immune system dysregulation and behavioral deficits observed in these disorders. As such, the asocial BTBR mouse strain displays both ASD relevant behaviors and persistent immune dysregulation, providing a model system that has and continues to be instructive in understanding the complex nature of ASD.

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“…Evidence of amygdala dysfunction in individuals with ASD (Baron-Cohen et al, 2000; Sweeten, Posey, Shekhar, & McDougle, 2002) has been suggested as a link to the high rates of anxiety in this population (Amaral, Bauman, & Schumann, 2003). Studies encompassing a variety of foci for knock-out mouse models of autism (including genes involved in serotonin, immunoglobulin, and corticosterone production) have reported both impaired social behavior and increased anxiety-related behavior in affected mice (Takayanagi et al, 2010; Balemans et al, 2010; Benno, Smirnova, Vera, Liggett, & Schanz, 2009; Lesch & Mossner, 1998). Additionally, the elevated rates of anxiety disorders in relatives of individuals with ASD suggest a common genetic link between the two symptom spectra (Piven & Palmer, 1999; Gadow, DeVincent, & Scheider, 2008; Bolton, Pickles, Murphy, & Rutter, 1998; Smalley, McCracken, & Tanguay, 1995; Delong & Dwyer, 1988).…”

mentioning

confidence: 99%

Exploring the Relationship Between Anxiety and Insistence on Sameness in Autism Spectrum Disorders

et al. 2012

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Elevated anxiety symptoms are one of the most common forms of psychopathology to co-occur with autism spectrum disorders (ASD). The purpose of this study was to explore the association between anxiety and ASD symptoms, particularly the degree to which the relationship is explained by Insistence on Sameness (IS) behaviors and/or cognitive ability. The sample included 1429 individuals aged 5:8 to 18:0 years who participated in the Simons Simplex Collection (SSC), a genetic consortium study of ASD. Child Behavior Checklist Anxiety Problems T-scores and Autism Diagnostic Interview-Revised “Insistence on Sameness” item raw totals were treated as both categorical and continuous measures of anxiety and IS respectively. Chronological age, verbal IQ, and a variety of ASD phenotype-related and other behavioral variables were assessed for potential association with anxiety and IS. Anxiety and IS continuous variables were minimally though significantly associated with each other and with chronological age and verbal IQ. Neither anxiety nor IS was associated with other core autism diagnostic scores. Anxiety was associated with a variety of other psychiatric and behavioral symptoms in ASD, including irritability, attention problems, and aggression, while IS was not. Anxiety and Insistence on Sameness appear to function as distinct constructs, each with a wide range of expression in children with ASD across age and IQ levels. Thus, both variables could be of use in ASD behavioral research or in dimensional approaches to genetic exploration. Unlike IS, however, anxiety is related to non-ASD-specific behavioral symptoms.

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Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype

Cited by 57 publications

References 27 publications

Co-learning facilitates memory in mice: A new avenue in social neuroscience

Co-learning facilitates memory in mice: A new avenue in social neuroscience

Inflammatory profiles in the BTBR mouse: How relevant are they to autism spectrum disorders?

Exploring the Relationship Between Anxiety and Insistence on Sameness in Autism Spectrum Disorders

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