1989
DOI: 10.1016/1043-6618(89)90239-9
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Exaggerated renal thromboxane and prostaglandin release by angiotensin II in suprarenal aortic coarctation hypertension

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Cited by 4 publications
(2 citation statements)
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“…Perfusion of isolated rabbit kidneys 7 days after suprarenal aortic constriction revealed these to be exquisitely sensitive to the vascular effects of Ang II as compared with a sham group. 31 In addition, Ang II caused the release of great quantities of PGEj, PGF^ 6-keto-PGF lm and thromboxane (TXB2) into the venous effluent. In sham kidneys Ang II did not cause release of TxBj, indicating a particular enhancement of this vasoconstrictor eicosanoid by arterial constriction.…”
Section: Various Phases Of Goldblatt Hypertension Phase I or Renin-anmentioning
confidence: 99%
“…Perfusion of isolated rabbit kidneys 7 days after suprarenal aortic constriction revealed these to be exquisitely sensitive to the vascular effects of Ang II as compared with a sham group. 31 In addition, Ang II caused the release of great quantities of PGEj, PGF^ 6-keto-PGF lm and thromboxane (TXB2) into the venous effluent. In sham kidneys Ang II did not cause release of TxBj, indicating a particular enhancement of this vasoconstrictor eicosanoid by arterial constriction.…”
Section: Various Phases Of Goldblatt Hypertension Phase I or Renin-anmentioning
confidence: 99%
“…It is possible that the increased availability of EPA or DHA or both may lead to an enhanced formation of resolvins, protectins and maresins that could have reversed the development of AAA. Yet, the other possibility that needs to be considered is the action of angiotensin-II on the formation of proinflammatory prostaglandins (PGs), thromboxanes (TXs) and leukotrienes (LTs) from AA, [7][8][9][10] an n-6 PUFA. It is likely that the supplementation of EPA and DHA displaced AA from the cell membrane phospholipid pool that can lead to an increased formation of LXA4 (see figure 3) and decreased formation of pro-inflammatory PGs, TXs and LTs (from AA).…”
Section: Pufas and Their Metabolites Angiotensin-ii Aa And Aaamentioning
confidence: 99%