Exaggerated circulating Th-1 cytokine response in early rheumatoid arthritis patients with nodules

Hodkinson, Bridget; Meyer, P.W.A.; Musenge, Eustasius; Ally, Mahmood Moosa Tar Mahomed; Tikly, Mohammed

doi:10.1016/j.cyto.2012.06.190

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Also called necrobiotic nodules, RNs are a common complication of rheumatoid arthritis and effect between 30-40% of patients [1,2]. Risk factors for developing RN in patients with rheumatoid arthritis include male sex, younger age at disease onset, longer duration of disease, mononuclear phagocyte-(MPH-) activated immune complexes, high circulating levels of Th1 cytokine and macrophage profiles, and seropositivity for rheumatoid factor [2][3][4][5][6]. Most commonly found near areas of subcutaneous pressure points, the pathogenesis of RN formation is thought to be related to damage of nearby microvasculature due to repetitive injury or chronic inflammation [1,5,6].…”

Section: Discussionmentioning

confidence: 99%

Sacral Rheumatoid Nodule: An Unusual Indication for Coccygectomy

Porter

Mejia-Munne

Krueger

et al. 2020

Case Reports in Surgery

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Here, we present a case report of a woman who presented with a large sacral rheumatoid nodule. This patient failed conservative treatment and presented in search of a surgical solution. We successfully removed her rheumatoid nodule using a surgical approach typically reserved for traumatic coccydynia. We show how coccygectomy, although a rare surgical procedure, was effective in treatment of a large rheumatoid nodule.

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Section: Discussionmentioning

confidence: 99%

Sacral Rheumatoid Nodule: An Unusual Indication for Coccygectomy

Porter

Mejia-Munne

Krueger

et al. 2020

Case Reports in Surgery

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“…A need to further investigate interventions in support programmes and biological therapies in this population was identified [24]  The HLA-DRB1 SE has significant expression in the Black South African RA population. Classification according to the Du Montcel's revised criteria [25] indicated an overexpression of high-risk alleles associated with elevated clinical and biomarkers linked with disease severity [7]  Rheumatoid nodules (RN), which were identified in 22.8% of the RA cohort, were significantly associated with HDA, SJC (swollen joint counts) and radiographic scores, as well as with certain cytokines, but not RF and ACPA [24]  After 6 months of therapy SDAI, ACPA and certain circulating cytokines were dramatically reduced in the cohort, indicating possible prognostic value of a select group of circulating cytokines when used in conjunction with ACPA. [11] Rheumatoid Factor (RF) and/or anti-Citrullinated Peptide antibodies (ACPA):…”

Section: Rheumatoid Arthritis Research In Africamentioning

confidence: 99%

Reliable and cost-effective serodiagnosis of rheumatoid arthritis

Meyer

Ally

2016

Rheumatol Int

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Early diagnosis of patients with rheumatoid arthritis (RA) optimises therapeutic benefit and the probability of achieving disease remission. Notwithstanding clinical acumen, early diagnosis is dependent on access to reliable serodiagnostic procedures, as well as on the discerning application and interpretation of these. In the case of RA, however, no diseasespecific serodiagnostic procedure is available due to the multifactorial and polygenic nature of this autoimmune disorder. This has resulted in the development of an array of serodiagnostic procedures based on the detection of autoantibodies reactive with various putative autoantigens. Other procedures based on measurement of elevations in the concentrations of systemic biomarkers of inflammation, most commonly acute phase reactants and cytokines/chemokines, are used as objective indices of disease activity.Following a brief overview of RA research in African populations, the current review is focused on those autoantibodies/biomarkers, specifically rheumatoid factor, anti-citrullinated peptide antibodies, and C-reactive protein, which are currently recognised as being the most reliable and cost-effective with respect to disease prediction and diagnosis, as well as in monitoring activity and outcome.

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“…Immunohistochemical studies of a rheumatoid nodules (RN) suggest that it is a Th1 granuloma with focal vasculitis. According to Hodkinson, patients with rheumatoid nodules have increased level of circulating Th1 and IL-12, IL-2, and VEGF levels and IL-8, than those without RN [32].…”

Section: Rheumatoid Nodulesmentioning

confidence: 99%

“…Etiology of RN is unknown, but there are series of studies suggesting that nodules are an effect of repeated trauma in the local tissue, which induce local vascular damage, and increase the level of proangiogenesis factors and cause granulation of tissue formations [32].…”

Section: Rheumatoid Nodulesmentioning

confidence: 99%