Exaggerated Blood Pressure Response to Exercise Is Associated With Augmented Rise of Angiotensin II During Exercise

Shim, Chi Young; Ha, Jong Won; Park, Sungha; Choi, Eui Young; Choi, Donghoon; Rim, Se Joong; Chung, Namsik

doi:10.1016/j.jacc.2008.03.052

Cited by 75 publications

(80 citation statements)

References 16 publications

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“…Angiotensin also mediates negative cardiovascular effects through the signaling pathways of reactive oxygen species, which amplifies oxidative stress provoked by other agents 33 and has been linked to increases in exercise BP. 34 According to previous work [35][36][37][38] showing the stronger predictive value of WC for incident HT, our results indicate that WC seems to be more closely associated with BP indices than any other obesity indices, such as BMI (Table 3). Such a conclusion is also consistent with findings from our previous longitudinal study, which indicated that maintaining low levels of visceral adiposity and high levels of CRF were both important targets for the maintenance of a healthy cardiometabolic risk profile (including BP) in apparently healthy individuals.…”

Section: Discussionsupporting

confidence: 71%

Insulin Resistance, Low Cardiorespiratory Fitness, and Increased Exercise Blood Pressure

Huot

Arsenault²,

Gaudreault³

et al. 2011

Hypertension

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Abstract-Individuals with insulin resistance and low cardiorespiratory fitness are frequently found to have an increased waist circumference and high exercise blood pressure. We tested the hypothesis that the relationships among insulin resistance, low cardiorespiratory fitness, and increased exercise blood pressure may be mediated by an elevated waist circumference. This study included 317 apparently healthy men and women (mean age: 34.8Ϯ12.8 years; mean body mass index: 26.1Ϯ5.2 kg/m 2 ). Exercise blood pressure values were measured using a submaximal ergometer test evaluating physical working capacity. Plasma insulin and glucose levels were measured during a 3-hour oral glucose tolerance test. Multivariate regression analyses showed that waist circumference accounted for 32.8% (PϽ0.0001) and 45.1% (PϽ0.0001) of the variance in exercise systolic blood pressure in men and women, respectively. Participants were classified into tertiles according to either insulin response, measured during the oral glucose tolerance test, or fitness levels and then further subdivided into 2 subgroups using sex-specific waist circumference thresholds. Individuals with an increased waist circumference (Ն94 cm and Ն80 cm for men and women, respectively) had higher exercise systolic blood pressure compared with individuals with low waist circumference, irrespective of their level of insulin resistance (10.6 versus 6.8, 12.2 versus 7.7, and 13.2 versus 8.7 mm Hg/metabolic equivalent, respectively, for the low, intermediate, and high tertiles; PϽ0.05) or fitness levels (13.1 versus 8.2, 12.0 versus 7.9, and 10.6 versus 7.1 mm Hg/metabolic equivalent, respectively, for the low, intermediate, and high tertiles; PϽ0.05). Individuals with a higher waist circumference have elevated exercise systolic blood pressure, regardless of their insulin sensitivity or level of cardiorespiratory fitness.

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Section: Discussionsupporting

confidence: 71%

Insulin Resistance, Low Cardiorespiratory Fitness, and Increased Exercise Blood Pressure

Huot

Arsenault²,

Gaudreault³

et al. 2011

Hypertension

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“…Although studies have demonstrated that exercise BP at the brachial level is an important marker of left ventricular hypertrophy [4,5], we also failed to find an association between an EBPR to exercise and left ventricular remodelling or diastolic dysfunction in our previous study [15]. Accordingly, the impact of EBPR to exercise on left ventricular function tends to be inconsistent.…”

Section: Central Haemodynamics and Exercise Blood Pressurecontrasting

confidence: 77%

“…Each individual provided written informed consent to the protocol approved by our institutional review board. Of the 141 individuals, 19 men and 43 women met the definition of an EBPR to exercise defined as a difference between peak and baseline SBP at least 60 mmHg in men and at least 50 mmHg in women during exercise testing [15]. After the exercise test, two individuals (one man, one woman) with a positive exercise echocardiogram for inducible ischemia and one individual with insufficient quality of the recorded central haemodynamics after exercise were additionally excluded.…”

Section: Study Participantsmentioning

confidence: 99%

Impact of central haemodynamics on left ventricular function in individuals with an exaggerated blood pressure response to exercise

Shim

Hong

Park

et al. 2015

Journal of Hypertension

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“…The RAS, one of the main controllers of systemic blood pressure, can contribute to systemic hypertension in humans by exaggerating vasopressor responses to drugs [30], nutrients [31], or exercise [32]. One study, using 3 days of water deprivation in pregnant rats, reported increments in fetal plasma sodium concentration and osmolality in association with increments in fetal liver angiotensinogen mRNA and plasma angiotensin I and angiotensin II levels [33•].…”

Section: Prenatal Exposure To Maternal Water Deprivation and The Renimentioning

confidence: 99%

Epigenetics and Hypertension

Millis

2010

Curr Hypertens Rep

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Epigenetics refers to mechanisms for environment-gene interactions (mainly by methylation of DNA and modification of histones) that do not alter the underlying base sequence of the gene. This article reviews evidence for epigenetic contributions to hypertension. For example, DNA methylation at CpG islands and histone acetylation pathways are known to limit nephron development, thereby unmasking hypertension associated with exposure to a high-salt diet. Maternal water deprivation and protein deficiency are shown to increase expression of renin-angiotensin system genes in the offspring. The methylation pattern of a serine protease inhibitor gene in human placentas is shown to be a marker for preeclampsia-associated hypertension. Mental stress induces phenylethanolamine n-methyltransferase, which may act as a DNA methylase and mimic the gene-silencing effects of methyl CpG binding protein-2 on the norepinephrine transporter gene, which, in turn, may exaggerate autonomic responsiveness. A disrupter of telomeric silencing (Dot1) is known to modulate the expression of a connective-tissue growth-factor gene associated with blood vessel remodeling, which could alter vascular compliance and elastance. Dot1a also interacts with the Af9 gene to produce high sodium channel permeability and silences the hydroxysteroid dehydrogenase-11β2 gene, thereby preventing metabolism of cortisol to cortisone and overstimulating aldosterone receptors. These findings indicate targets for environment-gene interactions in various hypertensive states and in essential hypertension.

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Exaggerated Blood Pressure Response to Exercise Is Associated With Augmented Rise of Angiotensin II During Exercise

Abstract: An exaggerated BP response to exercise was associated with augmented rise of Ang II during exercise.

Cited by 75 publications

References 16 publications

Insulin Resistance, Low Cardiorespiratory Fitness, and Increased Exercise Blood Pressure

Insulin Resistance, Low Cardiorespiratory Fitness, and Increased Exercise Blood Pressure

Impact of central haemodynamics on left ventricular function in individuals with an exaggerated blood pressure response to exercise

Epigenetics and Hypertension

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