Exact t and F Tests for Analyzing Studies with Multiple Endpoints

Läuter, Jürgen

doi:10.2307/2533057

Cited by 152 publications

(121 citation statements)

References 6 publications

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“…To this end, λCSF, grey matter T2, and grey matter ADC MRI outcomes were combined per region, since all these measures are substantially affected by changes in water content. For each region, the global null hypothesis stating that no differences exist within that region between the group with less than 20 SGTCS, and the group with more than 20 SGTCS of the included MRI modalities was tested using the ordinary least squares test of O-Brien and Läuter (Läuter, 1996;O'Brien, 1984 …”

Section: Discussionmentioning

confidence: 99%

Multimodal MRI Reveals Secondarily Generalized Seizure Related Abnormalities at 1.5 T: Preliminary Findings

Jansen¹,

Vlooswijk²,

Reijs³

et al. 2015

JMED

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Patients with chronic epilepsy, who have suffered a high number of secondarily generalized tonicclonic seizures (SGTCS) frequently show cognitive comorbidity. It is yet unclear whether a higher number of SGTCS is associated with tissue changes in the brain. We have investigated in patients with chronic epilepsy whether a high number of SGTCS accumulated over life is associated with microstructural changes in brain tissue. Sixteen patients with localization-related epilepsy with SGTCS underwent a multimodal quantitative Magnetic Resonance (MR) examination at 1.5 T, comprising T2 relaxometry, and diffusion weighted imaging to study microstructural changes in the temporal and frontal lobes. Fourteen healthy volunteers were also included to assess the effect of age. Patients with more than 20 SGTCS (n=8) showed a significantly lower IQ (-20%, p<0.05) compared to those with less than 20 SGTCS (n=8). Furthermore, regional combined multimodal analysis revealed that significant quantitative MRI changes, related to the number of SGTCS, were present in the frontal lobe but not in the temporal lobe. Moreover, the left and right frontal lobe generally displayed lower T2 relaxation times, smaller pericortical cerebrospinal fluid fraction and lower apparent diffusion coefficients, in the patients with more than 20 SGTCS. These findings suggest that SGTCS are associated with substantial changes in microstructural brain tissue characteristics within the frontal lobes. These frontal changes possibly explain the cognitive problems which are often observed in patients with many SGTCS. This knowledge may help in the development of treatment aimed at preventing decline in cognitive abilities.

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Section: Discussionmentioning

confidence: 99%

Multimodal MRI Reveals Secondarily Generalized Seizure Related Abnormalities at 1.5 T: Preliminary Findings

Jansen¹,

Vlooswijk²,

Reijs³

et al. 2015

JMED

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show abstract

“…27 For each cluster, a global null hypothesis stating that all differences of the included test scores are 0 was tested using the ordinary least squares (OLS) test. 28,29 For the 8 resulting 1-tailed P values, a Bonferroni correction for the significance level was applied. In addition, the means of the neurocognitive test scoresamongthesoccerplayerswereanalyzed.…”

Section: Chronic Traumatic Brain Injury In Soccermentioning

confidence: 99%

Neuropsychological Impairment in Amateur Soccer Players

Matser¹

1999

JAMA

345

207

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“…As both QC R1 and QC S0 represent contrast agent presence, QC R1 and QC S0 were combined to a summary value according to O'Brien and Läuter (30,31), which is more sensitive to contrast effects than the individual measures. Therefore, QC R1 and QC S0 were first standardized by z = [QC À mean(QC)/sd(QC)].…”

mentioning

confidence: 99%

Quantitative Molecular Magnetic Resonance Imaging of Tumor Angiogenesis Using cNGR-Labeled Paramagnetic Quantum Dots

et al. 2008

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The objective of this study was to develop and apply cyclic Asn-Gly-Arg (cNGR)-labeled paramagnetic quantum dots (cNGR-pQDs) for the noninvasive assessment of tumor angiogenic activity using quantitative in vivo molecular magnetic resonance imaging (MRI). cNGR was previously shown to colocalize with CD13, an aminopeptidase that is highly overexpressed on angiogenic tumor endothelium. Because angiogenesis is important for tumor growth and metastatization, its in vivo detection and quantification may allow objective diagnosis of tumor status and evaluation of treatment response. I.v. injection of cNGR-pQDs in tumorbearing mice resulted in increased quantitative contrast, comprising increased longitudinal relaxation rate and decreased proton visibility, in the tumor rim but not in tumor core or muscle tissue. This showed that cNGR-pQDs allow in vivo quantification and accurate localization of angiogenic activity. MRI results were validated using ex vivo two-photon laser scanning microscopy (TPLSM), which showed that cNGR-pQDs were primarily located on the surface of tumor endothelial cells and to a lesser extent in the vessel lumen. In contrast, unlabeled pQDs were not or only sparsely detected with both MRI and TPLSM, supporting a high specificity of cNGR-pQDs for angiogenic tumor vasculature. [Cancer Res 2008;68(18):7676-83]

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Exact t and F Tests for Analyzing Studies with Multiple Endpoints

Cited by 152 publications

References 6 publications

Multimodal MRI Reveals Secondarily Generalized Seizure Related Abnormalities at 1.5 T: Preliminary Findings

Multimodal MRI Reveals Secondarily Generalized Seizure Related Abnormalities at 1.5 T: Preliminary Findings

Neuropsychological Impairment in Amateur Soccer Players

Quantitative Molecular Magnetic Resonance Imaging of Tumor Angiogenesis Using cNGR-Labeled Paramagnetic Quantum Dots

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