Exacerbations of COPD

Viniol, Christian; Vogelmeier, Claus

doi:10.1183/16000617.0103-2017

Cited by 215 publications

(192 citation statements)

References 91 publications

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…Over the past decade, the relation between air pollution exposure and AECOPD has been investigated in several studies, but the results were non‐conclusive. Some epidemiological studies have demonstrated that short‐time exposure to air pollution significantly increased the risk of exacerbations, whereas others found no causality or association with only for selected pollutants …”

Section: Smoking and Air Pollutionmentioning

confidence: 99%

“…The eosinophil count is a marker for eosinophilic airway inflammation and a predictive biomarker for the efficacy of ICS treatment in patients with COPD exacerbations . COPD patients with eosinophilia (≥2%) have an increased risk of AECOPD . The first study to investigate the prevalence of blood eosinophilia (defined as ≥300 cells/L) among inpatients with AECOPD evidenced a higher frequency of exacerbations during the 1‐year follow‐up period compared to patients without eosinophilia .…”

Section: Biomarkersmentioning

confidence: 99%

“…The most common isolated microorganisms were Pseudomonas aeruginosa (4.16%) and Acinetobacter baumannii (4.16%) . Chronic pathogenic colonisation, especially with Pseudomonas aeruginosa , present in patients with COPD and bronchiectasis, is considered a potential mechanism for frequent AECOPD …”

Section: Comorbiditiesmentioning

confidence: 99%

“…Anxiety and depression are commonly associated with COPD and have a negative effect on exacerbations . Among COPD patients the prevalence of depression varies between 6% and 50% and of anxiety between 10% and 15.8%, depending on diagnostic methods .…”

Section: Comorbiditiesmentioning

confidence: 99%

“…The natural course of COPD is worsened by repeated episodes of exacerbations, which are defined as an acute worsening of respiratory symptoms requiring a change in treatment COPD exacerbations are important events associated with high impact on health status in COPD patients and it is well known that they are also a major determinant in disease progression, with inexorable decline of lung function . Severe exacerbations requiring hospitalisation are associated with a high risk of a subsequent exacerbation, a rapid decline in health status and high mortality in the weeks following every severe exacerbation .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Risk factors of chronic obstructive pulmonary disease exacerbations

Hogea

Tudorache

Fildan

et al. 2020

Clinical Respiratory J

View full text Add to dashboard Cite

Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterised by persistent respiratory symptoms and airflow limitation. COPD has a major impact on public health, mainly because of its increasing prevalence, morbidity and mortality. The natural course of COPD is aggravated by episodes of respiratory symptom worsening termed exacerbations that contribute to disease progression. Acute Exacerbations of COPD (AECOPD) can be triggered by a multitude of different factors, including respiratory tract infections, various exposures, prior exacerbations, non‐adherence to treatment and associated comorbidities. AECOPD are associated with an inexorable decline of lung function and a significantly worse survival outcome. This review will summarise the most important aspects regarding the impact of different factors that contribute to COPD exacerbations.

show abstract

Section: Smoking and Air Pollutionmentioning

confidence: 99%

Section: Biomarkersmentioning

confidence: 99%

Section: Comorbiditiesmentioning

confidence: 99%

Section: Comorbiditiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Risk factors of chronic obstructive pulmonary disease exacerbations

Hogea

Tudorache

Fildan

et al. 2020

Clinical Respiratory J

View full text Add to dashboard Cite

show abstract

Estimated Cardiorespiratory Hospitalizations Attributable to Influenza and Respiratory Syncytial Virus Among Long-term Care Facility Residents

et al. 2021

View full text Add to dashboard Cite

IMPORTANCE Older adults residing in long-term care facilities (LTCFs) are at a high risk of being infected with respiratory viruses, such as influenza and respiratory syncytial virus (RSV). Although these infections commonly have many cardiorespiratory sequelae, the national burden of influenzaand RSV-attributable cardiorespiratory events remains unknown for the multimorbid and vulnerable LTCF population.OBJECTIVE To estimate the incidence of cardiorespiratory hospitalizations that were attributable to influenza and RSV among LTCF residents and to quantify the economic burden of these hospitalizations on the US health care system by estimating their associated cost and length of stay. DESIGN, SETTING, AND PARTICIPANTS This retrospective cohort study used national MedicareProvider Analysis and Review inpatient claims and Minimum Data Set clinical assessments for 6 respiratory seasons (2011)(2012)(2013)(2014)(2015)(2016)(2017). Long-stay residents of LTCFs were identified as those living in the facility for at least 100 days (index date), aged 65 years or older, and with 6 months of continuous enrollment in Medicare Part A were included. Follow-up occurred from the resident's index date until the first hospitalization, discharge from the LTCF, disenrollment from Medicare, death, or the end of the study. Residents could re-enter the sample; thus, long-stay episodes of care were identified. Data analysis was performed between January 1 and September 30, 2020.EXPOSURES Seasonal circulating pandemic 2009 influenza A(H1N1), human influenza A(H3N2), influenza B, and RSV. MAIN OUTCOMES AND MEASURESCardiorespiratory hospitalizations (eg, asthma exacerbation, heart failure) were identified using primary diagnosis codes. Influenza-and RSV-attributable cardiorespiratory events were estimated using a negative binomial regression model adjusted for weekly circulating influenza and RSV testing data. Length of stay and costs of influenza-and RSV-attributable events were then estimated. RESULTSThe study population comprised 2 909 106 LTCF residents with 3 138 962 long-stay episodes and 5 079 872 person-years of follow-up. Overall, 10 939 (95% CI, 9413-12 464) influenzaand RSV-attributable cardiorespiratory events occurred, with an incidence of 215 (95% CI, 185-245) events per 100 000 person-years. The cost of influenza-and RSV-attributable cardiorespiratory events was $91 055 393 (95% CI, $77 885 316-$104 225 470), and the length of stay was 56 858 (95% CI, 48 757-64 968) days. CONCLUSIONS AND RELEVANCEThis study found that many cardiorespiratory hospitalizations among LTCF residents in the US were attributable to seasonal influenza and RSV. To minimize the (continued) Key Points Question What is the burden of cardiorespiratory events attributable to influenza and respiratory syncytial virus (RSV) among older adults residing in long-term care facilities (LTCFs) in the US? Findings In this cohort study of 2 909 106 LTCF residents, a total of 10 939 influenza-and RSV-attributable cardiorespiratory events occurred from 2011 to 2017 f...

show abstract