Exacerbation of Parkinsonism by Methyldopa

Rosenblum, Andrew M.

doi:10.1001/jama.1980.03310240019007

Cited by 11 publications

(1 citation statement)

References 2 publications

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“…In selecting the appropriate antihypertensives, active substances which, based on their pharmacological properties, can cause drug-induced parkinsonism, should be avoided. Studies on this relationship have been done for alpha-methyldopa (Strang 1966 ; Vaidya et al 1970 ; Rosenblum and Montgomery 1980 ), reserpine (Birkmayer and Hornykiewicz 1964 ; Lorenc-Koci et al 1995 ), calcium channel blockers (flunarizine, cinnarizine, amlodipine) (Montastruc et al 1994 ; Sempere et al 1995 ; Teive 2002 ), diltiazem (Dick and Barold 1989 ; Graham and Stewart-Wynne 1994 ; Remblier et al 2001 ), verapamil (Malaterre et al 1992 ; Padrell et al 1995 ), captopril (Sandyk 1985 ) and moxonidine (Webster and Koch 1996 ).…”

Section: General Medical Comorbiditymentioning

confidence: 99%

Parkinson’s disease between internal medicine and neurology

Csóti¹,

Jost

Reichmann³

2015

J Neural Transm

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General medical problems and complications have a major impact on the quality of life in all stages of Parkinson’s disease. To introduce an effective treatment, a comprehensive analysis of the various clinical symptoms must be undertaken. One must distinguish between (1) diseases which arise independently of Parkinson’s disease, and (2) diseases which are a direct or indirect consequence of Parkinson’s disease. Medical comorbidity may induce additional limitations to physical strength and coping strategies, and may thus restrict the efficacy of the physical therapy which is essential for treating hypokinetic-rigid symptoms. In selecting the appropriate medication for the treatment of any additional medical symptoms, which may arise, its limitations, contraindications and interactions with dopaminergic substances have to be taken into consideration. General medical symptoms and organ manifestations may also arise as a direct consequence of the autonomic dysfunction associated with Parkinson’s disease. As the disease progresses, additional non-parkinsonian symptoms can be of concern. Furthermore, the side effects of Parkinson medications may necessitate the involvement of other medical specialists. In this review, we will discuss the various general medical aspects of Parkinson’s disease.

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