Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation
Xinyue Cui,
Bo Wang,
Dongjian Han
et al.
Abstract:Syntaxin 17 (STX17) has been identified as a crucial factor in mediating the fusion of autophagosomes and lysosomes. However, its specific involvement in the context of atherosclerosis (AS) remains unclear. This study sought to elucidate the role and mechanistic contributions of STX17 in the initiation and progression of AS. Utilizing both in vivo and in vitro AS model systems, we employed ApoE knockout (KO) mice subjected to a high‐fat diet and human umbilical vein endothelial cells (HUVECs) treated with oxid… Show more
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