Exacerbated response to oxidative stress in the Retinitis Pigmentosa Cerkl mouse model triggers retinal degeneration pathways upon acute light stress

García-Arroyo, Rocío; Domènech, Elena B.; Herrera-Úbeda, Carlos; Asensi, Miguel A.; Núñez de Arenas, Cristina; Cuezva, José M.; Garcia-Fernàndez, Jordi; Pallardó, Federico V.; Mirra, Serena; Marfany, Gemma

doi:10.1016/j.redox.2023.102862

Redox Biology

2023

DOI: 10.1016/j.redox.2023.102862

|View full text |Cite

Exacerbated response to oxidative stress in the Retinitis Pigmentosa Cerkl mouse model triggers retinal degeneration pathways upon acute light stress

Rocío García-Arroyo,

Elena B. Domènech,

Carlos Herrera-Úbeda

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

Chen,

Lin

et al. 2023

Heliyon

View full text Add to dashboard Cite

The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

Chen,

Lin

et al. 2023

Heliyon

View full text Add to dashboard Cite

Excessive linoleic acid induces muscle oxidative stress through 5-lipoxygenase-dependent peroxidation

Cao,

Guo,

Dai

et al. 2024

Redox Biology

View full text Add to dashboard Cite

Analysis of the Skin and Brain Transcriptome of Normally Pigmented and Pseudo-Albino Southern Flounder (Paralichthys lethostigma) Juveniles to Study the Molecular Mechanisms of Hypopigmentation and Its Implications for Species Survival in the Natural Environment

Blandon,

DiBona,

Battenhouse

et al. 2024

IJMS

View full text Add to dashboard Cite

Southern flounder skin pigmentation is a critical phenotypic characteristic for this species’ survival in the natural environment. Normal pigmentation allows rapid changes of color for concealment to capture prey and UV light protection. In contrast, highly visible hypopigmented pseudo-albinos exhibit a compromised immune system and are vulnerable to predation, sensitive to UV exposure, and likely have poor survival in the wild. Skin and brain tissue samples from normally pigmented and hypopigmented individuals were analyzed with next-generation RNA sequencing. A total of 1,589,613 transcripts were used to identify 952,825 genes to assemble a de novo transcriptome, with 99.43% of genes mapped to the assembly. Differential gene expression and gene enrichment analysis of contrasting tissues and phenotypes revealed that pseudo-albino individuals appeared more susceptible to environmental stress, UV light exposure, hypoxia, and osmotic stress. The pseudo-albinos’ restricted immune response showed upregulated genes linked to cancer development, signaling and response, skin tissue formation, regeneration, and healing. The data indicate that a modified skin collagen structure likely affects melanocyte differentiation and distribution, generating the pseudo-albino phenotype. In addition, the comparison of the brain transcriptome revealed changes in myelination and melanocyte stem cell activity, which may indicate modified brain function, reduced melanocyte migration, and impaired vision.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Exacerbated response to oxidative stress in the Retinitis Pigmentosa Cerkl mouse model triggers retinal degeneration pathways upon acute light stress

Cited by 3 publications

References 56 publications

The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

Excessive linoleic acid induces muscle oxidative stress through 5-lipoxygenase-dependent peroxidation

Analysis of the Skin and Brain Transcriptome of Normally Pigmented and Pseudo-Albino Southern Flounder (Paralichthys lethostigma) Juveniles to Study the Molecular Mechanisms of Hypopigmentation and Its Implications for Species Survival in the Natural Environment

Contact Info

Product

Resources

About