Exacerbated physical fatigue and mental fatigue in Parkinson's disease

Lou, Jau Shin; Kearns, G. L.; Oken, Barry; Sexton, Gary; Nutt, John G.

doi:10.1002/mds.1042

Cited by 214 publications

(202 citation statements)

References 12 publications

Supporting

Mentioning

184

Contrasting

Unclassified

Order By: Relevance

“…Finally, given the heterogeneity and diversity of symptoms in CFS, it is also highly probable that not one, but several, pathophysiological mechanisms are involved in the syndrome of chronic fatigue. Consistent with this notion, data obtained in patients with Parkinson disease afflicted with fatigue indicate that mental fatigue and physical fatigue (as assessed by the MFI scale) are independent symptoms, suggesting that these two forms of fatigue involve separate etiologies and pathophysiological pathways (Lou et al, 2001). Accordingly, whereas dopamine agents appeared to be useful for improving physical fatigue (Lou et al, 2003), drugs targeting serotonin and/or noradrenergic function may be more adapted for the treatment/alleviation of mental fatigue and cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 77%

Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome

Capuron

Welberg

Heim

et al. 2006

Neuropsychopharmacol

View full text Add to dashboard Cite

Patients with chronic fatigue syndrome (CFS) frequently complain of cognitive dysfunction. However, evidence of cognitive impairment in CFS patients has been found in some, but not other, studies. This heterogeneity in findings may stem from the relative presence of mental fatigue in the patient populations examined. The present study assessed this possibility in a population-based sample of CFS patients. In all, 43 patients with CFS defined by the criteria of the 1994 research case definition using measurements recommended by the 2003 International CFS Study Group, and 53 age-, sex-, and race/ethnicity-matched nonfatigued subjects were included in the study. Mental fatigue was assessed using the mental fatigue subscale of the multidimensional fatigue inventory. Cognitive function was evaluated using an automated battery of computerized tests (Cambridge neuropsychological test automated battery (CANTAB)) that assessed psychomotor function, planning and problem-solving abilities, and memory and attentional performance. CFS patients with significant complaints of mental fatigue (score of mental fatigue 2 standard deviations above the mean of nonfatigued subjects) exhibited significant impairment in the spatial working memory and sustained attention (rapid visual information processing) tasks when compared to CFS patients with low complaints of mental fatigue and nonfatigued subjects. In CFS patients with significant mental fatigue, sustained attention performance was impaired only in the final stages of the test, indicating greater cognitive fatigability in these patients. CFS patients with low mental fatigue displayed performance comparable to nonfatigued subjects on all tests of the CANTAB battery. These findings show strong concordance between subjective complaints of mental fatigue and objective measurement of cognitive impairment in CFS patients and suggest that mental fatigue is an important component of CFS-related cognitive dysfunction.

show abstract

Section: Discussionmentioning

confidence: 77%

Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome

Capuron

Welberg

Heim

et al. 2006

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Its cause remains unclear. For example, while some reports suggest an association between fatigue and the underlying parkinsonism (5, 9), others do not (10,11).…”

mentioning

confidence: 99%

“…Studies have tended to use fatigue scales from generic health status questionnaires or approaches not validated in PD (4)(5)(6)(7)(8)(10)(11)(12). Although generic health status questionnaires have been validated broadly, their subscales are brief and often lack sufficient detail for accurately measuring individuals.…”

mentioning

confidence: 99%

Measuring Fatigue in Parkinson's Disease: A Psychometric Study of Two Brief Generic Fatigue Questionnaires

Hagell

Höglund

Reimer

et al. 2006

Journal of Pain and Symptom Management

View full text Add to dashboard Cite

This study evaluated and compared the measurement properties of the 13-item FACITFatigue Scale (FACIT-F) and the 9-item Fatigue Severity Scale (FSS) in 118 consecutive Parkinson's disease (PD) patients, using traditional and Rasch measurement methodologies.Both questionnaires exhibited excellent data quality and reliability (coefficient alpha ≥0.9), acceptable rating scale functionality, and discriminated between fatigued and non-fatigued patients. Factor and Rasch analyses provided general support for unidimensionality of both the FACIT-F and FSS, although they do not appear to measure identical aspects of fatigue.No signs of differential item functioning (DIF) were found for the FACIT-F whereas potential age DIF was detected for 2 FSS items. These results support the measurement validity of both questionnaires in PD, although the FACIT-F displayed better measurement precision and modest psychometric advantages over the FSS. Availability of psychometrically sound fatigue measures that are applicable across disorders provides a sound basis for advancing the understanding of this common and distressing complaint. Fatigue can be defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion (1) and is a common complaint in a range of medical conditions, including many neurological disorders (1-3). In a clinical context, fatigue is considered to be a multidimensional concept with physical, emotional, cognitive, and social aspects. This can pose a challenge to measurement. In Parkinson's disease (PD), fatigue has been reported in 40-65% of patients and although many consider it to be one of their most disabling symptoms, it often remains undetected in clinical practice (4)(5)(6)(7)(8). Its cause remains unclear. For example, while some reports suggest an association between fatigue and the underlying parkinsonism (5, 9), others do not (10, 11).One reason for such mixed results may relate to how fatigue has been assessed. Studies have tended to use fatigue scales from generic health status questionnaires or approaches not validated in [10][11][12]. Although generic health status questionnaires have been validated broadly, their subscales are brief and often lack sufficient detail for accurately measuring individuals. For example, the Energy subscale of the Nottingham Health Profile (NHP-EN) (13) has been found to be only a coarse measure of fatigue (14). Other employed instruments have been validated in other patient groups but remain untested in terms of their measurement properties in PD. This is a limitation because traditional psychometric properties are sample dependent. Thus their performance in specific applications is important to consider in the context of accumulated experience with an instrument (15). There is thus a need for fatigue measures with documented reliability and validity in specific patient populations, such as PD, that also allow for comparisons with other patient groups and healthy control populations (3).We therefore sought to identify and validate an availa...

show abstract

“…Fatigue is one of the most common non-motor manifestations in patients with Parkinson's disease (PD) [1]- [4]. Fatigue is multifactorial and has been set as a general sense of tiredness or difficulties in starting an activity on the physical or mental sector experienced by an individual during many days or weeks [5].…”

Section: Introductionmentioning

confidence: 99%

“…Fatigue is linked with serotonergic dysfunction in basal ganglia and limbic circuits [8] [9], and in thalamus, additional cortical and striatal regions [10]. The exacerbated fatigue may lead the patient to have difficulties in starting and/or completing activities related to carrying weight, manual work, running, walking [4] [5], higher risk of falls [11] and deficits of attention and action planning [4] [5], worsening the quality of life of individuals with PD [12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Physical Activity Levels on Fatigue Perception in Patients with Parkinson’s Disease and Neurologically Healthy Individuals

Santos¹,

Barbieri²,

Orcioli‐Silva³

et al. 2014

Health

View full text Add to dashboard Cite

Exacerbated physical fatigue and mental fatigue in Parkinson's disease

Abstract: PD patients have increased physical fatigue and mental fatigue compared to normals. Physical fatigue and mental fatigue are independent symptoms in PD that need to be assessed and treated separately.

Cited by 214 publications

References 12 publications

Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome

Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome

Measuring Fatigue in Parkinson's Disease: A Psychometric Study of Two Brief Generic Fatigue Questionnaires

Effects of Physical Activity Levels on Fatigue Perception in Patients with Parkinson’s Disease and Neurologically Healthy Individuals

Contact Info

Product

Resources

About