Ex vivo tissue modelling informs drug selection for rare cancers
Jenny H. Lee,
Zizhen Ming,
Veronica K. Y. Cheung
et al.
Abstract:The identification and therapeutic targeting of actionable gene mutations across many cancer types has resulted in improved response rates in a minority of patients. The identification of actionable mutations is usually not sufficient to ensure complete nor durable responses, and in rare cancers, where no therapeutic standard of care exists, precision medicine indications are often based on pan‐cancer data. The inclusion of functional data, however, can provide evidence of oncogene dependence and guide treatme… Show more
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