Ex vivo therapeutic screening of metastatic cSCC: A review of methodological considerations for clinical implementation
Jessica Conley,
Jay R. Perry,
Bruce Ashford
et al.
Abstract:Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy worldwide, with most deaths caused by locally advanced and metastatic disease. Treatment of resectable metastases is typically limited to invasive surgery with adjuvant radiotherapy; however, many patients fail to respond and there is minimal data to predict response or propose effective alternatives. Precision medicine could improve this, though genomic biomarkers remain elusive in the high mutational background and genomic complexi… Show more
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