“…The contact with the entire root canal wall, especially in the apical region, is crucial for the effectiveness of irrigation solutions in root canal treatment (Torabinejad et al, ). The smear layer removal effectiveness has been investigated for single or combined use of irrigant activation/delivery systems and was shown to be more effective than CSI (Kumar, Bahuguna, & Manan, ; Mancini et al, ; Rödig et al, ; Schiavotelo et al, ), but the smear layer was not completely removed by any irrigation system. Considering that the recent literature lacks any reports about the smear removal effectiveness of syringe irrigation and irrigant activation systems in the event of file separation, this study aimed to investigate the effectiveness of CSI, PUI, Vibringe, and EndoActivator in the presence of SF.…”