Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration

Nebelung, Sven; Tingart, Markus; Pufe, Thomas; Kuhl, Christiane K.; Jahr, Holger; Truhn, Daniel

doi:10.1007/s00256-016-2480-x

Cited by 41 publications

(46 citation statements)

References 39 publications

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“…After importing the MR raw data and time constants of each pixel into Matlab R2015a software (Matlab, Natick, MA, USA), spatially resolved quantitative T1r maps were generated of the mid-sagittal image using predefined monoexponential fitting routines 12,25,30 . R 2 statistics was used to check fit quality.…”

Section: Mri Data Analysismentioning

confidence: 99%

Non-invasive T1ρ mapping of the human cartilage response to loading and unloading

Nebelung

Sondern

Jahr

et al. 2018

Osteoarthritis and Cartilage

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Section: Mri Data Analysismentioning

confidence: 99%

Non-invasive T1ρ mapping of the human cartilage response to loading and unloading

Nebelung

Sondern

Jahr

et al. 2018

Osteoarthritis and Cartilage

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“…In healthy subjects at the unloaded situation, inner lateral and medial posterior horn values were higher than in the outer zone, suggesting underlying differences in macromolecular organization in these subregions of the meniscus. Similarly, Nebelung et al 36 investigated an ex vivo quantitative multiparametric MRI mapping study of degenerated human menisci that showed T 1 , T 1ρ , T 2 , and UTE-T 2 * relaxation times are functionally related to histological meniscus degeneration.…”

Section: Discussionmentioning

confidence: 99%

Biexponential T_1ρ relaxation mapping of human knee menisci

Baboli

Sharafi

Chang

et al. 2019

Magnetic Resonance Imaging

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Background Measuring T1ρ in the knee menisci can potentially be used as noninvasive biomarkers in detecting early‐stage osteoarthritis (OA). Purpose To demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee menisci. Study Type Prospective. Population Eight healthy volunteers with no known inflammation, trauma, or pain in the knee and three symptomatic subjects with early knee OA. Field Strength/Sequence Customized Turbo‐FLASH sequence to acquire 3D‐T1ρ‐weighted images on a 3 T MRI scanner. Assessment T1ρ relaxation values were assessed in 11 meniscal regions of interest (ROIs) using monoexponential and biexponential models. Statistical Tests Nonparametric rank‐sum tests, Kruskal–Wallis test, and coefficient of variation. Results The mean monoexponential T1ρ relaxation in the lateral menisci were 28.05 ± 4.2 msec and 37.06 ± 10.64 msec for healthy subjects and early knee OA patients, respectively, while the short and long components were 8.07 ± 0.5 msec and 72.35 ± 3.2 msec for healthy subjects and 2.63 ± 2.99 msec and 55.27 ± 24.76 msec for early knee OA patients, respectively. The mean monoexponential T1ρ relaxation in the medial menisci were 34.30 ± 3.8 msec and 37.26 ± 11.38 msec for healthy and OA patients, respectively, while the short and long components were 7.76 ± 0.7 msec and 72.19 ± 4.2 msec for healthy subjects and 3.06 ± 3.24 msec and 55.27 ± 24.59 msec for OA patients, respectively. Statistically significant (P ≤ 0.05) differences were observed in the monoexponential relaxation between some of the ROIs. The T1ρ,short was significantly lower (P = 0.02) in the patients than controls. The rmsCV% ranges were 1.51–16.6%, 3.59–14.3%, and 4.91–15.6% for T1ρ‐mono, T1ρ‐short, and T1ρ‐long, respectively. Data Conclusion Our results showed that in all ROIs, T1ρ relaxation times of outer zones (red zones) were less than inner zones (white zones). Monoexponential T1ρ was increased in medial, lateral, and body menisci of early OA while the biexponential numbers were decreased in early OA patients. Level of Evidence: 2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2019;50:824–835.

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“…Overall qDESS T 2 and MOAKS scores for cartilage, stratified by degree of OA, are summarized in Table 4. [7,16,29]). Differences in qDESS T 2 values were statistically significant between the three subject groups (p < 0.01; Fig.…”

Section: Reproducibility Of Klg Scoringmentioning

confidence: 99%

Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan

et al. 2019

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Objectives To assess the discriminative power of a 5-min quantitative double-echo steady-state (qDESS) sequence for simultaneous T 2 measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard. Methods Fifty-three subjects were included and divided over three groups based on radiographic and clinical knee OA: 20 subjects with no OA (Kellgren-Lawrence grade (KLG) 0), 18 with mild OA (KLG2), and 15 with moderate OA (KLG3). All patients underwent a 5-min qDESS scan. We measured T 2 relaxation times in four cartilage and four meniscus regions of interest (ROIs) and performed structural OA evaluation with the MRI Osteoarthritis Knee Score (MOAKS) using qDESS with multiplanar reformatting. Between-group differences in T 2 values and MOAKS were calculated using ANOVA. Correlations of the reference standard (i.e., radiographic knee OA) with T 2 and MOAKS were assessed with correlation analyses for ordinal variables. Results In cartilage, mean T 2 values were 36.1 ± SD 4.3, 40.6 ± 5.9, and 47.1 ± 4.3 ms for no, mild, and moderate OA, respectively (p < 0.001). In menisci, mean T 2 values were 15 ± 3.6, 17.5 ± 3.8, and 20.6 ± 4.7 ms for no, mild, and moderate OA, respectively (p < 0.001). Statistically significant correlations were found between radiographic OA and T 2 and between radiographic OA and MOAKS in all ROIs (p < 0.05). Conclusion Quantitative T 2 and structural assessment of cartilage and meniscus, using a single 5-min qDESS scan, can distinguish between different grades of radiographic OA, demonstrating the potential of qDESS as an efficient tool for OA imaging. Key Points • Quantitative T 2 values of cartilage and meniscus as well as structural assessment of the knee with a single 5-min quantitative double-echo steady-state (qDESS) scan can distinguish between different grades of knee osteoarthritis (OA). • Quantitative and structural qDESS-based measurements correlate significantly with the reference standard, radiographic degree of OA, for all cartilage and meniscus regions. • By providing quantitative measurements and diagnostic image quality in one rapid MRI scan, qDESS has great potential for application in large-scale clinical trials in knee OA. AbbreviationsACR American College of Rheumatology KLG Kellgren and Lawrence grade MOAKS MRI Osteoarthritis Knee Score MRI Magnetic resonance imaging OA Osteoarthritis qDESS Quantitative double-echo steady-state ROI Region of interest SD Standard deviation TE Echo time 95% CI 95% confidence intervalPublisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration

Cited by 41 publications

References 39 publications

Non-invasive T1ρ mapping of the human cartilage response to loading and unloading

Non-invasive T1ρ mapping of the human cartilage response to loading and unloading

Biexponential T_1ρ relaxation mapping of human knee menisci

Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan

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Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration

Cited by 41 publications

References 39 publications

Non-invasive T1ρ mapping of the human cartilage response to loading and unloading

Non-invasive T1ρ mapping of the human cartilage response to loading and unloading

Biexponential T1ρ relaxation mapping of human knee menisci

Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan

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Biexponential T_1ρ relaxation mapping of human knee menisci