Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

Reis, Jordana Grazziela A Coelho Dos; Ferreira, Geovane Marques; Lourenço, Alice Aparecida; Ribeiro, Ágata Lopes; Mata, Camila da Silveira Martins da Pacheco; Oliveira, Patrícia de; Marques, Daisymara Priscila de Almeida; Ferreira, Linziane Lopes; Clarindo, Felipe Alves; Silva, Murillo Ferreira da; Filho, Heitor Portella Póvoas; Oliveira, Nilson Roberto Ribeiro; Sodré, Maisah Meyhr D’Carmo; Gadelha, Sandra Rocha; Albuquerque, George Rêgo; Maciel, Bianca Mendes; Mariano, Ana Paula Melo; Silva, Mylene de Melo; Fontana, Renato; Marin, Lauro Juliano; Carlos, Renata Santiago Alberto; Lopes, Amanda Teixeira Sampaio; Ferreira, Fabrício Barbosa; Santos, Uener Ribeiro dos; Santana, Íris Terezinha Santos de; Fehlberg, Hllytchaikra Ferraz; Rezende, Rachel Passos; Dias, João Carlos T; Gross, Eduardo; Goulart, Gisele Assis Castro; Santiago, Marie Gabriele; Lemos, Ana Paula Motta Lavigne de; Conceição, Aline Oliveira da; Romano, Carla Cristina; Carvalho, Luciana Debortoli de; Filho, Olindo Assis Martins; Quadros, Claudio Almeida; Morris, David L.; Valle, Sarah J.

doi:10.1016/j.biopha.2022.112753

Cited by 8 publications

(14 citation statements)

References 44 publications

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“…The investigators demonstrated that the efficacy of this agent was associated with a significant decline in MIP-1α levels. Likewise, it was shown that the use of bromelain and acetylcysteine resulted in a significant reduction of MIP-1α levels in the tracheal aspirate of Covid-19 patients [41] .…”

Section: Discussionmentioning

confidence: 95%

Relation between macrophage inflammatory protein-1 and intercellular adhesion molecule-1 and computed tomography findings in critically-ill saudi covid-19 patients

Alsayed

Hamza

Ali

et al. 2022

Journal of Infection and Public Health

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Section: Discussionmentioning

confidence: 95%

Relation between macrophage inflammatory protein-1 and intercellular adhesion molecule-1 and computed tomography findings in critically-ill saudi covid-19 patients

Alsayed

Hamza

Ali

et al. 2022

Journal of Infection and Public Health

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“…The authors found that this drug exerted a potent mucolytic effect on COVID-19 sputum ex vivo in a dose-dependent manner. In addition, they observed anti-inflammatory activity with a decrease in the effect of cytokine storm, regulatory cytokines (IL-5, IL-10, IL-13, IL-1Ra), and chemokines (MIP-1alpha, CXCL8, MIP-1b, MCP-1, and IP-10) compared with NAC alone and the control group [ 81 ]. Selected studies focusing on the use of bromelain alone or in combination for the treatment of respiratory infections in children are shown in Table 2 .…”

Section: Use Of Bromelain In Children and Adolescentsmentioning

confidence: 99%

Current Uses of Bromelain in Children: A Narrative Review

Locci,

Chicconi,

Antonucci

2024

Children

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Bromelain is a complex natural mixture of sulfhydryl-containing proteolytic enzymes that can be extracted from the stem or fruit of the pineapple. This compound is considered a safe nutraceutical, has been used to treat various health problems, and is also popular as a health-promoting dietary supplement. There is continued interest in bromelain due to its remarkable therapeutic properties. The mechanism of action of bromelain appears to extend beyond its proteolytic activity as a digestive enzyme, encompassing a range of effects (mucolytic, anti-inflammatory, anticoagulant, and antiedematous effects). Little is known about the clinical use of bromelain in pediatrics, as most of the available data come from in vitro and animal studies, as well as a few RCTs in adults. This narrative review was aimed at highlighting the main aspects of the use of bromelain in children, which still appears to be limited compared to its potential. Relevant articles were identified through searches in MEDLINE, PubMed, and EMBASE. There is no conclusive evidence to support the use of bromelain in children, but the limited literature data suggest that its addition to standard therapy may be beneficial in treating conditions such as upper respiratory tract infections, specific dental conditions, and burns. Further studies, including RCTs in pediatric settings, are needed to better elucidate the mechanism of action and properties of bromelain in various therapeutic areas.

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“…The study showed that 1200 mg/day of oral NAC administration significantly reduced the progression rates to severe respiratory failure (SRF), mechanical ventilation requirement, and mortality [ 223 ]. In addition, a combination of NAC and bromelain showed even better mucolytic and anti-inflammatory activity ex vivo in tracheal aspirate samples from COVID-19 patients compared to NAC treatment ore controls [ 224 ]. Another study evaluated the high dose of oral 600 mg NAC every eight hours.…”

Section: Potentials For Therapeutic Approaches Based On Antioxidant T...mentioning

confidence: 99%

Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review

et al. 2022

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The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.

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Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

Cited by 8 publications

References 44 publications

Relation between macrophage inflammatory protein-1 and intercellular adhesion molecule-1 and computed tomography findings in critically-ill saudi covid-19 patients

Relation between macrophage inflammatory protein-1 and intercellular adhesion molecule-1 and computed tomography findings in critically-ill saudi covid-19 patients

Current Uses of Bromelain in Children: A Narrative Review

Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review

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