Ex-vivo mechanical characterisation of the breast Cooper’s ligaments

Briot, N.; Chagnon, Grégory; Masri, Christopher; Girard, Édouard

doi:10.1080/10255842.2020.1812155

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…In the literature, there is only one study concerning the mechanical properties of Cooper’s ligaments, however, the samples came from a cadaver. Briot et al (2020) performed uniaxial tensile fracture tests on these ligaments and they obtained a Young’s modulus equal to 5.8 ± 4.2 MPa, a rupture strain as 8.6% ± 4.2% and a rupture stress of 1.9 ± 2.5 MPa. The results were fitted with a hyperelastic constitutive equation, the Neo-Hookean model.…”

Section: Breast Tissue: Basic Concepts and Mechanical Propertiesmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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Female breast cancer was the most prevalent cancer worldwide in 2020, according to the Global Cancer Observatory. As a prophylactic measure or as a treatment, mastectomy and lumpectomy are often performed at women. Following these surgeries, women normally do a breast reconstruction to minimize the impact on their physical appearance and, hence, on their mental health, associated with self-image issues. Nowadays, breast reconstruction is based on autologous tissues or implants, which both have disadvantages, such as volume loss over time or capsular contracture, respectively. Tissue engineering and regenerative medicine can bring better solutions and overcome these current limitations. Even though more knowledge needs to be acquired, the combination of biomaterial scaffolds and autologous cells appears to be a promising approach for breast reconstruction. With the growth and improvement of additive manufacturing, three dimensional (3D) printing has been demonstrating a lot of potential to produce complex scaffolds with high resolution. Natural and synthetic materials have been studied in this context and seeded mainly with adipose derived stem cells (ADSCs) since they have a high capability of differentiation. The scaffold must mimic the environment of the extracellular matrix (ECM) of the native tissue, being a structural support for cells to adhere, proliferate and migrate. Hydrogels (e.g., gelatin, alginate, collagen, and fibrin) have been a biomaterial widely studied for this purpose since their matrix resembles the natural ECM of the native tissues. A powerful tool that can be used in parallel with experimental techniques is finite element (FE) modeling, which can aid the measurement of mechanical properties of either breast tissues or scaffolds. FE models may help in the simulation of the whole breast or scaffold under different conditions, predicting what might happen in real life. Therefore, this review gives an overall summary concerning the human breast, specifically its mechanical properties using experimental and FE analysis, and the tissue engineering approaches to regenerate this particular tissue, along with FE models.

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Section: Breast Tissue: Basic Concepts and Mechanical Propertiesmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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“…It is assumed, in a first approximation, to represent them with a hyperelastic constitutive equation. If the ligaments would have been considered as one-dimension structures, an isotropic constitutive law could have been adopted Briot et al (2020). The method was effective in describing the stress-strain curve in the fibre direction but it is clear that the response in the orthogonal direction is not representative.…”

Section: Modellingmentioning

confidence: 99%

“…In a preliminary study presented during the 25th Conference of the French Biomechanical Society Briot et al (2020), an ex vivo experiment of the mechanical behaviour of Cooper's ligaments under uniaxial tensile test was performed (based on a cadaver dissection) in order to propose a constitutive model for these ligaments. This paper aims at completing this preliminary study, with a detailed analysis of the 28 uniaxial tensile tests and with the proposal of an original anisotropic hyperelastic constitutive law to model the mechanical behaviour of Cooper's ligaments.…”

Section: Introductionmentioning

confidence: 99%

Experimental characterisation and modelling of breast Cooper’s ligaments

Briot

Chagnon

Burlet³

et al. 2022

Biomech Model Mechanobiol

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The aim of this study was to characterise the mechanical behaviour of Cooper's ligaments. Such ligaments are collagenous breast tissue that create a three-dimensional structure over the entire breast volume. Ten ligaments were extracted from a human cadaver, from which 28 samples were cut and used to perform uniaxial tensile tests. Histological analysis showed that the main direction of the fibres visible to the naked eye corresponds to the orientation of the fibres on a microscopic scale. The specimens were cut according to this orientation, which allowed the sample to be stretched in the main fibre direction. From these experimental stretch/stress curves, an original anisotropic hyperelastic constitutive law is proposed to model the behaviour of Cooper's ligaments and the material parameter validity is discussed.

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Mechanical properties of breast tissue

Dempsey

Samani

2023

Biomechanics of the Female Reproductive System: Breast and Pelvic Organs

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Ex-vivo mechanical characterisation of the breast Cooper’s ligaments

Cited by 4 publications

References 3 publications

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Experimental characterisation and modelling of breast Cooper’s ligaments

Mechanical properties of breast tissue

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