Ex vivo measurement of lumbar intervertebral disc pressure using fibre-Bragg gratings

Dennison, Christopher R.; Wild, Peter; Byrnes, Peter; Saari, Amy; Itshayek, Eyal; Wilson, Derek; Zhu, Qingan; Dvorak, Marcel F.; Cripton, Peter A.; Wilson, David R.

doi:10.1016/j.jbiomech.2007.07.015

Cited by 40 publications

(25 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As of yet, there are no validated means to measure IDP noninvasively, and many groups have utilized the same invasive approach as we have (Adams et al 1996a;Ekstrom et al 2004;Dennison et al 2008). In agreement with these reports and our own previous work, our current study demonstrated that the transient mechanics on the level of the motion segment were not affected by the insertion of the fibre optic sensor (Fig.…”

Section: Discussionsupporting

confidence: 91%

Role of load history in intervertebral disc mechanics and intradiscal pressure generation

Hwang

Gabai

et al. 2011

Biomech Model Mechanobiol

View full text Add to dashboard Cite

Solid-fluid interactions play an important role in mediating viscoelastic behaviour of biological tissues. In the intervertebral disc, water content is governed by a number of factors, including age, disease and mechanical loads, leading to changes in stiffness characteristics. We hypothesized that zonal stress distributions depend on load history, or the prior stresses experienced by the disc. To investigate these effects, rat caudal motion segments were subjected to compressive creep biomechanical testing in vitro using a protocol that consisted of two phases: a Prestress Phase (varied to represent different histories of load) followed immediately by an Exertion Phase, identical across all Prestress groups. Three analytical models were used to fit the experimental data in order to evaluate load history effects on gross and zonal disc mechanics. Model results indicated that while gross transient response was insensitive to load history, there may be changes in the internal mechanics of the disc. In particular, a fluid transport model suggested that the role of the nucleus pulposus in resisting creep during Exertion depended on Prestress conditions. Separate experiments using similarly defined load history regimens were performed to verify these predictions by measuring intradiscal pressure with a fibre optic sensor. We found that the ability for intradiscal pressure generation was load history-dependent and exhibited even greater sensitivity than predicted by analytical models. A 0.5 MPa Exertion load resulted in 537.2 kPa IDP for low magnitude Prestress compared with 373.7 kPa for high magnitude Prestress. Based on these measurements, we developed a simple model that may describe the pressure-shear environment in the nucleus pulposus. These findings may have important implications on our understanding of how mechanical stress contributes to disc health and disease etiology.

show abstract

Section: Discussionsupporting

confidence: 91%

Role of load history in intervertebral disc mechanics and intradiscal pressure generation

Hwang

Gabai

et al. 2011

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…The comparison between these results with the failure pressure of the annular fibers reported in previous studies for several MS models (Table 2) reveals that the values documented on this report are appreciably lower than the more recent studies, performed by Schechtman et al (2006) and Veres et al (2010). In fact, several studies reported the magnitude of the rupture values obtained in this study as within the normal range of physiological IDP for human samples (Claus et al, 2008;Dennison et al, 2008;Sato et al, 1999;Wilke et al, 1999). Schechtman et al (2006) investigated the intrinsic failure strength of the intact bovine caudal disc under inflation, injecting a colored gel with a hydraulic actuator: the mean hy- This study 2015 Lumbar porcine 0.62 ± 0.08 drostatic failure pressure was found to be 18 ± 3 MPa.…”

Section: Discussionsupporting

confidence: 62%

The intradiscal failure pressure on porcine lumbar intervertebral discs: an experimental approach

et al. 2015

View full text Add to dashboard Cite

Abstract. The intervertebral disc is submitted to complex loading during its normal daily activities which are responsible for variations of the hydrostatic pressure in its structure. Thus, the determination of the magnitude of failure hydrostatic pressure is essential as a potential for the evaluation of the mechanisms that promote the weakening and the disruption of the annular fibers, commonly linked to herniation process on the spine column. However, few studies include the determination of the failure pressure on discs and the results are widely contradictory. Therefore, the objective of the present work is to determine the values of IDP that promotes the disc disruption. To achieve this goal, the tests were performed using a hydraulic cylinder that inflates the intervertebral disc. The results revealed a mean pressure failure of 0.62 ± 0.08 MPa for lumbar porcine samples (n = 6). From this approach it can be concluded that (1) the potential for disc injury may exist at low pressures for lumbar porcine discs when compared several animal and human ones; (2) the rupture of human cervical and porcine lumbar annular fibers could occur for values of intradiscal pressure that are within the physiological range.

show abstract

“…88,93,115 Recently, FBG sensors have also been proposed to assess pressure; namely, in the nucleus pulposus of the intervertebral discs of the spine. 19,20,60,116 However, these apply only to ex vivo experiments. Thus, innovative solutions are mandatory for in vivo and clinical studies, namely to be integrated into specific diagnostic procedures of the spine (e.g., discometry) and surgical procedures (e.g., arthrodesis and arthroplasty).…”

Section: Fiber-optic Pressure Sensorsmentioning

confidence: 99%

“…Ex vivo experiments were carried out to sense prosthetic misalignments trough the analysis of contact stress distribution during knee flexion/extension. 27 Dennison et al 19,20,116 used minimally invasive FBG sensors to assess the pressure in the nucleus pulposus of intervertebral discs. It was recognized that large diameters of previously used nonoptical sensors (e.g., 1.5 mm OD) 173 could interfere with the normal behavior of the joint and induce degenerative effects.…”

Section: Intra-articular Pressurementioning

confidence: 99%

“…[173][174][175] Dennison's first proposal consisted of a bare FBG sensor (125 μm OD, 10 mm length, Bragg wavelength 1550 nm) that was left directly in contact with the nucleus pulposus. 116 After that, a configuration with increased spatial resolution and less affected by the inhomogeneity of the nucleus material was presented. 19,20 This new sensor was housed within a stainless-steel hypodermic tube allowing only just the tip to sense the external pressure.…”

Section: Intra-articular Pressurementioning

confidence: 99%

See 1 more Smart Citation

Review of fiber-optic pressure sensors for biomedical and biomechanical applications

Roriz

Frazão

Ribeiro³

et al. 2013

J. Biomed. Opt

192

View full text Add to dashboard Cite

Abstract. As optical fibers revolutionize the way data is carried in telecommunications, the same is happening in the world of sensing. Fiber-optic sensors (FOS) rely on the principle of changing the properties of light that propagate in the fiber due to the effect of a specific physical or chemical parameter. We demonstrate the potentialities of this sensing concept to assess pressure in biomedical and biomechanical applications. FOSs are introduced after an overview of conventional sensors that are being used in the field. Pointing out their limitations, particularly as minimally invasive sensors, is also the starting point to argue FOSs are an alternative or a substitution technology. Even so, this technology will be more or less effective depending on the efforts to present more affordable turnkey solutions and peer-reviewed papers reporting in vivo experiments and clinical trials. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

Ex vivo measurement of lumbar intervertebral disc pressure using fibre-Bragg gratings

Cited by 40 publications

References 18 publications

Role of load history in intervertebral disc mechanics and intradiscal pressure generation

Role of load history in intervertebral disc mechanics and intradiscal pressure generation

The intradiscal failure pressure on porcine lumbar intervertebral discs: an experimental approach

Review of fiber-optic pressure sensors for biomedical and biomechanical applications

Contact Info

Product

Resources

About