Ex vivo lung perfusion

Abstract

lung grafts from DCD can experience additional injuries, including aspiration, warm ischemia, hypoxemia, and hypotension (shock lung). Primary graft dysfunction (PGD), which derives from ischemia-reperfusion injury plus other underlying graft injuries, impairs graft quality that, in turn,

Current achievements and future applications of ex vivo lung perfusion; where do we go from here?

“…Various techniques, protocols, and devices for successful EVLP have previously been described in length by our and other groups. 10,11 In summary, 3 different EVLP protocols have been reported: (1) Toronto protocol; (2) Lund protocol;…”

“…The value of perfusate biomarkers and extravascular lung water measurement techniques is still investigational. 11…”

High Doses of Inhaled Nitric Oxide as an Innovative Antimicrobial Strategy for Lung Infections

“…It has been used clinically in our center over the past decade to allow a more objective assessment of donor lung function, thereby successfully increasing the use of donor lungs for transplantation [81]. EVLP has also been used to study innovative therapies for lung regeneration and modification, such as surfactant replacement, ABO antigen depletion, α1 antitrypsin administration, gene therapies, photodynamic therapies, ultraviolet C irradiation and high-dose antibiotics [82,83].…”

“…EVLP has also been used to study innovative therapies for lung regeneration and modification, such as surfactant replacement, ABO antigen depletion, α1 antitrypsin administration, gene therapies, photodynamic therapies, ultraviolet C irradiation and high-dose antibiotics [ 82 , 83 ].…”

“… Concept illustration of the normothermic ex vivo lung perfusion (EVLP) platform and opportunities for treatment strategies. Adapted from [ 79 , 82 ]. …”