Ex vivo expansion of hematopoietic stem cells

Wang, Yuan; Sugimura, Ryohichi

doi:10.1016/j.yexcr.2023.113599

Cited by 4 publications

(4 citation statements)

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“…Nearly two fifth (39.9) worried about their baby's cord blood to be used for different purposes and more than one third (36.7%) prefer to have their baby's stem cells to store in private banks rather than in public banks. Figure (5): reveals total levels of attitude regarding blood cord stem cells' banking and donation among the studied women. It was observed that about half (49.5%) of the studied pregnant women had negative attitude level regarding blood cord stem cells' banking and donation.…”

Section: Resultsmentioning

confidence: 99%

“…However, 50.5% of them had positive attitude. Table (5): shows correlation between total scores of knowledge and attitude and socio-demographic characteristics of the studied pregnant women. It was observed that there was highly positive significant correlation between total score of knowledge of the studied pregnant women with their marital status, educational level, family type, monthly income (p< 0.01) and positive significant correlation with pregnancy number, gestational age, and pregnancy problems (p< 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…Performing a bone marrow or stem cell transplant is the medical term for this procedure. Peripheral blood (PB), bone marrow (BM), and umbilical cord blood (UCB) are among the organs that contain HSCs (5). Similar to bone marrow and peripheral blood, umbilical cord blood is a rich source of stem cells for transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Pregnant Women' Knowledge and Attitudes toward Cord Blood Stem Cell Banking and Donation at Gharbia Governorate, Egypt

Awad,

EL-Said,

Khaton

2023

Tanta Scientific Nursing Journal

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Background: In the light of the increase in incidence of immunity diseases, metabolic disorders and blood diseases, the need for cord blood stem cell as therapeutic option has become essential. Parents, especially mothers need to decide if they would like to store their infant's cord blood and donate it. They need to be aware of options exists and information needed. Aim of the study was to assess pregnant women knowledge and attitudes toward cord blood stem cell banking and donation at Gharbia Governorate, Egypt. Setting: This study was conducted in Antenatal Clinics at the largest ten Central Hospitals and ten Rural Health Units in Gharbia Governorate, Egypt. Subjects: A convenient sample of one thousand (1000) pregnant women from the previous settings. Tools: Two tools were used: Tool I: Structured Interview Schedule: It included three parts: -Socio-demographic data of the pregnant women, obstetric history of the pregnant women and Pregnant Women's knowledge toward cord blood stem cells & its banking and donation. Tool II: Pregnant women' attitudes toward donation and banking of cord blood stem cells. Results: the majority (78.5%) of the studied pregnant women had low level of knowledge regarding cord blood and stem cell & its banking and donation and nearly the half (49.5%) of them had negative attitudes, with statistically significant relationship between total knowledge and attitudes scores. Education and occupation of the pregnant women have a statistically significant correlation with total knowledge and attitudes scores. Conclusion and recommendations: the levels of pregnant women knowledge and attitudes regarding cord blood stem cell banking and donation were very low and need to be improved. Therefore, it is recommended to conduct health education programs and companies through health authorities and the media to increase awareness and support pregnant women's positive attitudes toward cord blood stem cell banking and donation to develop and expand the status of umbilical cord blood banking in Egypt.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Pregnant Women' Knowledge and Attitudes toward Cord Blood Stem Cell Banking and Donation at Gharbia Governorate, Egypt

Awad,

EL-Said,

Khaton

2023

Tanta Scientific Nursing Journal

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“…The application of stem cells in tissue engineering or clinical studies requires large quantities of cells in vitro [60,61] Therefore, establishing an in vitro culture platform for the large-scale expansion of stem cells is one of the main purposes for hydrogel application. Under most culture conditions, differentiation takes precedence over expansion, so methods of maintaining self-renewal of stem cells and blocking differentiation are essential for stem cellbased therapy.…”

Section: Stem Cell Expansionmentioning

confidence: 99%

Potential Role of Hydrogels in Stem Cell Culture and Hepatocyte Differentiation

Luo,

Gao

2024

Nano Biomedicine and Engineering

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Stem cells are cells with self-renewal, reproductive activity, and multiple differentiation potential. The native cell-extracellular matrix (ECM) is a hydrated network of proteins and polysaccharides that provide the surrounding environment to maintain stem cells. Hydrogels possess broadly tunable biofunctions and adequate mechanical strength, as well as ECM-like conditions for better cellular activity. Hydrogels are considered one of the most utilized and relevant options in terms of mimicking the native ECM .This review article summarizes the recent advances in the field of using hydrogels as a stem cell niche to regulate cell fate from design strategies. Furthermore, we also review how hydrogels regulate stem cell fate and differentiate into hepatocytes. Looking forward, we envision that with the adoption of an increasing number of interdisciplinary methods, it is reasonable to combine multiple strategies to prepare hydrogels with enhanced performance. Due to the special arrangement or interaction between multiple scales and multiple components, a new combination of hydrogels has emerged, which provides opportunities for further innovation of hydrogels in regulating cell fate.

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