Ex-vivo efficacy of commercially available anthelmintics against blood feeding stomach worm Haemonchus contortus of ruminants

Parvin, Shanaz; Dey, Anita Rani; Shohana, Nusrat Nowrin; Anisuzzaman, Md.; Rony, Sharmin Aqter; Akter, Shirin; Talukder, Hasanuzzaman; Alam, Mohammad Zahangir

doi:10.1007/s12639-023-01565-y

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…On the other hand, in this study, LEV and IVM have been found to be very effective in killing adult A. galli . LEV and IVM had been shown to kill several nematodes both in ex vivo and in vivo researches ( Dey et al, 2020 ; Parvin et al, 2023 ), including A. galli in the present studies. Ascaridia galli is the most economically important nematode of poultry and prevalent in the major parts of the world ( Ara et al, 2021 ; Shohana et al, 2023 ).…”

Section: Discussionsupporting

confidence: 55%

“…Thus, we speculate that A. galli prevalent in Bangladesh may develop resistance to ABZ and MBZ. Although ABZ- and MBZ-resistance to A. galli is yet to be determined but benzimidazole resistance to Haemonchus contortus , a blood feeding stomach worm of ruminants have been reported ( Dey et al, 2020 ; Parvin et al, 2022 ; Parvin et al, 2023 ). On the other hand, in this study, LEV and IVM have been found to be very effective in killing adult A. galli .…”

Section: Discussionmentioning

confidence: 99%

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Ascaridia galli, a common nematode in semiscavenging indigenous chickens in Bangladesh: epidemiology, genetic diversity, pathobiology, ex vivo culture, and anthelmintic efficacy

Ritu,

Labony,

Hossain

et al. 2024

Poultry Science

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Ascaridia galli, a common nematode in semiscavenging indigenous chickens in Bangladesh: epidemiology, genetic diversity, pathobiology, ex vivo culture, and anthelmintic efficacy

Ritu,

Labony,

Hossain

et al. 2024

Poultry Science

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“…Although anthelmintic resistance is rapidly growing globally, including in Bangladesh [ 43 , 44 ], routine anthelmintic deworming has long been used as endoparasite control. This study found that deworming could significantly reduce parasites in caprine.…”

Section: Discussionmentioning

confidence: 99%

Diversity and prevalence of gastrointestinal parasites of Black Bengal goats in Natore, Bangladesh

Chakrabortty¹,

Shohana²,

Begum³

et al. 2023

J Adv Vet Anim Res

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Objectives: The objective of this work was to estimate the diversity of gastrointestinal (GI) para¬site species, their prevalence, and risk factors in Black Bengal goats (BBGs) of Natore, Bangladesh. Materials and Methods: Fecal samples from randomly selected 260 BBGs were processed through Stoll’s ova counting method, floatation, and simple sedimentation method. Microscopy-based identification of parasitic eggs, cysts, or oocysts was made. A semi-structured question¬naire-based data on host and management practices were collected from the owner. Data analysis was done using Statistical Package for Social Sciences. Results: The overall prevalence of GI parasites in BBGs was 65.4%, with an individual prevalence of 8.5% for Fasciola gigantica, 21.5% for Paramphistomum spp., 20% for Haemonchus spp., 34.2% for Strongyloides spp., 8.5% for Trichuris spp., and 9.2% for Eimeria spp. No significant effect of host age, gender, body condition, animal rearing system, or housing floor type was observed on parasitism. Animals of young age, female, poorly body-conditioned, living in a free-range system, and housed on a muddy floor had a relatively higher susceptibility to infection. Deworming had a significant impact on reducing the frequency of caprine GI parasitism. Conclusions: Despite the significant effect of anthelmintic, the elevated prevalence of GI parasites in BBGs suggests a critical need for developing effective strategies to prevent caprine parasitoses.

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“…In the last decade, reports of gastrointestinal nematode (GNI) populations resistant to anthelmintics in sheep have increased; as a result, research has been oriented toward the search for new control alternatives such as natural products [1][2][3]. Mushrooms of the genus Pleurotus are considered a traditional component in the diet of several cultures worldwide [4].…”

Section: Introductionmentioning

confidence: 99%

1H-NMR Metabolomic Study of the Mushroom Pleurotus djamor for the Identification of Nematocidal Compounds

Pineda-Alegría,

Peña-Rodríguez,

Cardoso-Taketa

et al. 2024

Pharmaceuticals

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Due to the increasing populations of anthelmintic-resistant gastrointestinal nematodes and as a consequence of the adverse effects of synthetic drugs, this study focuses on the search for secondary metabolites with nematocidal activity from the edible mushroom Pleurotus djamor using The proton nuclear magnetic resonance (1H-NMR) metabolomics. The highest activity was shown by the ethyl acetate fractions of mycelium (EC50 290.8 µg/mL) and basidiomes (EC50 282.7 µg/mL). Principal component analysis (PCA) and hierarchical data analysis (HCA) of the 1H-NMR metabolic profiles data showed that the ethanolic extracts, the ethyl acetate, butanol, and water fractions from mycelium have different metabolic profiles than those from basidiomes, while low polarity (hexane) fractions from both stages of fungal development show similar profiles. Orthogonal partial least squares discriminant analysis (OPLS-DA) allowed the identification of signals in the 1H-NMR metabolic profile associated with nematocidal activity. The signals yielded via OPLS-DA and bidimensional NMR analysis allowed the identification of uracil as a component in the ethyl acetate fraction from basidiomes, with an EC50 of 237.7 µg/mL. The results obtained showed that chemometric analyses of the 1H-NMR metabolic profiles represent a viable strategy for the identification of bioactive compounds from samples with complex chemical profiles.

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Ex-vivo efficacy of commercially available anthelmintics against blood feeding stomach worm Haemonchus contortus of ruminants

Cited by 4 publications

References 30 publications

Ascaridia galli, a common nematode in semiscavenging indigenous chickens in Bangladesh: epidemiology, genetic diversity, pathobiology, ex vivo culture, and anthelmintic efficacy

Ascaridia galli, a common nematode in semiscavenging indigenous chickens in Bangladesh: epidemiology, genetic diversity, pathobiology, ex vivo culture, and anthelmintic efficacy

Diversity and prevalence of gastrointestinal parasites of Black Bengal goats in Natore, Bangladesh

1H-NMR Metabolomic Study of the Mushroom Pleurotus djamor for the Identification of Nematocidal Compounds

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