Ex vivo determination of nerve and surrounding tissue optical properties in rats and human cadavers for nerve-sparing surgical applications

Haugen, Ezekiel; Throckmorton, Graham A.; Walter, Alec B.; Guo, Zaiyang; Baba, Justin S.; Mahadevan‐Jansen, Anita

doi:10.1117/12.2608860

Cited by 1 publication

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“…Broadband optical property phantoms. Multipigment phantoms matching the broadband absorption and reduced scattering coefficients of [(a), (b)] muscle and [(c), (d)] nerve tissue from human cadavers 33 . The spectral optical properties for each were compared to the theoretical best fit of a traditional phantom made using only TiO2 and India ink.…”

Section: Resultsmentioning

confidence: 99%

“…Using the concentration-dependent optical properties of the different pigments, phantoms were made to match the optical properties of muscle and nerve from human cadavers, which our group previously reported. 33 These two tissue types were chosen as they represent two possible extremes, with muscle having relatively high absorption and low scattering and nerve having the opposite.…”

Section: Methodsmentioning

confidence: 99%

“…The quantitative assessment of the similarity of the phantom optical properties to that of their respective tissues can be found in Table 2. From at the analysis of the SAMs, it can be seen that the phantoms are better able to match the shape of the reduced scattering coefficient as compared 33 The spectral optical properties for each were compared to the theoretical best fit of a traditional phantom made using only TiO 2 and India ink.…”

Section: Tissue Optical Property Phantomsmentioning

confidence: 99%

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Development of a platform for broadband, spectra-fitted, tissue optical phantoms

Walter

Jansen

2023

J. Biomed. Opt.

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Significance: Current methods of producing optical phantoms are incapable of accurately capturing the wavelength-dependent properties of tissue critical for many optical modalities. Aim:We aim to introduce a method of producing solid, inorganic phantoms whose wavelengthdependent optical properties can be matched to those of tissue over the wavelength range of 370 to 950 nm.Approach: The concentration-dependent optical properties of 20 pigments were characterized and used to determine combinations that result in optimal fits compared to the target properties over the full spectrum. Phantoms matching the optical properties of muscle and nerve, the diffuse reflectance of pale and melanistic skin, and the chromophore concentrations of a computational skin model with varying oxygen saturation (StO 2 ) were made with this method.Results: Both optical property phantoms were found to accurately mimic their respective tissues' absorption and scattering properties across the entire spectrum. The diffuse reflectance phantoms were able to closely approximate skin reflectance regardless of skin type. All three computational skin phantoms were found to have emulated chromophore concentrations close to the model, with an average percent error for the StO 2 of 4.31%.Conclusions: This multipigment phantom platform represents a powerful tool for creating spectrally accurate tissue phantoms, which should increase the availability of standards for many optical techniques.

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