Ex vivo characterization of pathologic fluids with quantitative phase-contrast computed tomography

Richter, V.; Willner, Marian; Henningsen, John; Birnbacher, Lorenz; Marschner, Mathias; Herzen, Julia; Kimm, Melanie A.; Noël, Peter B.; Rummeny, Ernst J.; Pfeiffer, Franz; Fingerle, Alexander A.

doi:10.1016/j.ejrad.2016.11.014

Cited by 3 publications

(2 citation statements)

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“…An analysis study of blood and pathological fluids complemented research in that direction. Different types of infectious fluids were differentiated based on their composition like cell, protein, and water content [ 66 ]. GBPC-CT experiments are typically performed with fixed samples to prevent degradation.…”

Section: Applications Of Quantitative Gbpc-ctmentioning

confidence: 99%

“…Application of quantitative GBPC-CT covers myocardial infarct [61], atherosclerotic plaque [62], and tumors of kidney [63], liver [64], pancreas [65], brain [67][68][69], testis [70], and breast [41,57,72,73]. Moreover, biochemical or biomedical fluids can be characterized quantitatively [66,74]. In addition, Hounsfield units for the phase (HUp) [57,75] or the effective atomic number Z eff can be calculated [76][77][78].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative X-ray phase contrast computed tomography with grating interferometry

Birnbacher

Braig

Pfeiffer

et al. 2021

Eur J Nucl Med Mol Imaging

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The ability of biomedical imaging data to be of quantitative nature is getting increasingly important with the ongoing developments in data science. In contrast to conventional attenuation-based X-ray imaging, grating-based phase contrast computed tomography (GBPC-CT) is a phase contrast micro-CT imaging technique that can provide high soft tissue contrast at high spatial resolution. While there is a variety of different phase contrast imaging techniques, GBPC-CT can be applied with laboratory X-ray sources and enables quantitative determination of electron density and effective atomic number. In this review article, we present quantitative GBPC-CT with the focus on biomedical applications.

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Section: Applications Of Quantitative Gbpc-ctmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative X-ray phase contrast computed tomography with grating interferometry

Birnbacher

Braig

Pfeiffer

et al. 2021

Eur J Nucl Med Mol Imaging

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Quantitative characterization of ex vivo breast tissue via x-ray phase-contrast tomography

Chen

Zhang

et al. 2019

XST

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BACKGROUND: Grating-based X-ray phase-contrast imaging (GPCI) has received growing interests in recent years due to its high capability of visualizing soft tissue. Breast imaging is one of the most promising candidates for the first clinical application of this imaging modality. OBJECTIVE: In this work, quantitative breast tissue characterization based on GPCI computed tomography (CT) is investigated with a laboratory X-ray tube through a comparison between attenuation-based CT images and phase-contrast CT images. METHODS:The Hounsfield units (HU) scale was introduced to phase-contrast images due to its wide application in clinical medicine. In this work, instead of water, plastic cylinders composed of polyethylene terephthalate (PET) was treated as the calibration material. An alternative test-retest reliability (TRR) was presented to evaluate the repeatability of GPCI. Comparison between attenuation-based CT imaging and GPCI CT imaging was operated with the use of statistical analysis methods like histograms and receiver operating characteristic (ROC) curves. RESULTS:The determined mean TRR related to cylinders is slightly larger in phase-contrast imaging (0.93) than that in attenuation-based imaging (0.89). With respect to distinguishing breast tissues, the AUC (area under curve) values of ROC curves of phase-contrast images are higher than that of attenuation-based images. CONCLUSIONS: An ex vivo study of GPCI shows that it is a stable imaging modality for visualizing the breast tissue with good repeatability, and that it could be of potential for the diagnosis of breast cancer as well.

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Establishing a Foundation for the In Vivo Visualization of Intravascular Blood with Photon-Counting Technology in Spectral Imaging in Cranial CT

Klempka,

Neumayer,

Schröder

et al. 2024

Diagnostics

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Background: Advances in computed tomography (CT) technology, particularly photon-counting CT (PCCT), are reshaping the possibilities for medical imaging. PCCT in spectral imaging enables the high-resolution visualization of tissues with material-specific accuracy. This study aims to establish a foundational approach for the in vivo visualization of intracranial blood using PCCT, focusing on non-enhanced imaging techniques and spectral imaging capabilities. Methods: We employed photon-counting detector within a spectral CT framework to differentiate between venous and arterial intracranial blood. Our analysis included not only monoenergetic +67 keV reconstructions, but also images from virtual non-contrast and iodine phases, enabling detailed assessments of blood’s characteristics without the use of contrast agents. Results: Our findings demonstrate the ability of PCCT to provide clear and distinct visualizations of intracranial vascular structures. We quantified the signal-to-noise ratio across different imaging phases and found consistent enhancements in image clarity, particularly in the detection and differentiation of arterial and venous blood. Conclusion: PCCT offers a robust platform for the non-invasive and detailed visualization of intravascular intracranial blood. With its superior resolution and specific imaging capabilities, PCCT lays the groundwork for advancing clinical applications and research, notably in the diagnosis and management of intracranial disorders. This technology promises to improve diagnostic accuracy by enabling more precise imaging assessments.

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Ex vivo characterization of pathologic fluids with quantitative phase-contrast computed tomography

Cited by 3 publications

References 15 publications

Quantitative X-ray phase contrast computed tomography with grating interferometry

Quantitative X-ray phase contrast computed tomography with grating interferometry

Quantitative characterization of ex vivo breast tissue via x-ray phase-contrast tomography

Establishing a Foundation for the In Vivo Visualization of Intravascular Blood with Photon-Counting Technology in Spectral Imaging in Cranial CT

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